Zobrazeno 1 - 10
of 16
pro vyhledávání: '"M O, Sikpi"'
Autor:
M. O. Sikpi, Y Wang
Publikováno v:
International Journal of Radiation Biology. 76:177-187
Unlike normal cells, ataxia telangiectasia (A-T) cells do not exhibit enhanced double-strand-break (dsb)-repair fidelity after ionizing radiation (IR) exposure. DNA-repair induction and other responses to IR are mediated by signalling pathways that a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00e647f85c7937f44e0c7cf6141ffb7b
https://doi.org/10.1080/095530000138835
https://doi.org/10.1080/095530000138835
Publikováno v:
International Journal of Radiation Biology. 75:893-901
To determine if cells from the cancer-prone autosomal recessive disorder ataxia telangiectasia (A-T) are defective in responding to stimuli other than ionizing-radiation (IR) damage.The induction of c-jun transcripts by IR, by phorbol 12-myristate 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bafc8422eec54888f1a1304e5c2a480b
https://doi.org/10.1080/095530099139953
https://doi.org/10.1080/095530099139953
Publikováno v:
International Journal of Radiation Biology. 62:555-562
The mutagenicity of open-circular DNA (containing base damage and single-strand breaks) and linear DNA (containing base damage, single-strand breaks, and one double-strand break) produced in vitro by gamma-irradiation of shuttle vector pZ189, was ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e0656cab09ade0d18e1a4fff81507b2
https://doi.org/10.1080/09553009214552471
https://doi.org/10.1080/09553009214552471
Publikováno v:
International Journal of Radiation Biology. 59:1115-1126
The frequencies and types of mutations induced in the target gene, supF-tRNA, of the shuttle vector pZ189 were analysed following the replication of the gamma-irradiated plasmid in the human lymphoblastoid cell line, GM606. The mutation frequency mea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2964cddc91508662f76af5be0f1e5bc1
https://doi.org/10.1080/09553009114551021
https://doi.org/10.1080/09553009114551021
Publikováno v:
Molecular Carcinogenesis. 3:30-36
The supF gene of the recombinant shuttle plasmid pZ190 (modified pZ189) was used as a target to study the nature of mutations induced by N-methyl-N-nitrosourea (MNU) in human cells. Treatment of the intact plasmid with MNU followed by its replication
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5001de69a6c12a7d81b96e115c019fb3
https://doi.org/10.1002/mc.2940030108
https://doi.org/10.1002/mc.2940030108
Publikováno v:
Mutation research. 460(1)
Ionizing radiation (IR) enhances double-strand-break (DSB)-repair fidelity in plasmids processed in normal lymphoblasts but not in lymphoblasts from ataxia telangiectasia (A–T) patients. Putatively, signal-transduction pathways mediate this DNA-rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ca4762486b466c5f76cc70a50a1853
https://pubmed.ncbi.nlm.nih.gov/10856832
https://pubmed.ncbi.nlm.nih.gov/10856832
Autor:
M. O. Sikpi, Sanjay M. Mallya
Publikováno v:
Mutation research. 434(2)
Ionizing radiation (IR) triggers apoptosis, cell-cycle arrest, and DNA-repair induction in mammalian cells. These responses are mediated by proteins, including p53, which are activated or induced by IR. To determine the role of p53 in double-strand b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df4f85b17a1977d29b7f57b006619fe8
https://pubmed.ncbi.nlm.nih.gov/10422540
https://pubmed.ncbi.nlm.nih.gov/10422540
Defective modulation of double-strand break repair in ataxia telangiectasia cells by gamma radiation
Publikováno v:
Radiation research. 150(6)
Ataxia telangiectasia (AT) cells are defective in responding to damage induced by ionizing radiation. To study the modulation of double-strand break (DSB) repair by ionizing radiation and a defect in such modulation in AT cells, we compared processin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fd7a3cbb28c39d4ab9d9687be8954fd5
https://pubmed.ncbi.nlm.nih.gov/9840182
https://pubmed.ncbi.nlm.nih.gov/9840182
Autor:
M. O. Sikpi, Sanjay M. Mallya
Publikováno v:
International journal of radiation biology. 74(2)
To determine the involvement of p53 in ionizing radiation-induced excision and recombination repair.Shuttle vector pZ189 containing radiation-induced single strand breaks plus base damage (ocDNA), ultraviolet-radiation damage (uvDNA), or a restrictio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38f8b9a34e2635e4b5cc5e6079f67740
https://pubmed.ncbi.nlm.nih.gov/9712552
https://pubmed.ncbi.nlm.nih.gov/9712552
Publikováno v:
International journal of radiation biology. 65(2)
The repair of damaged DNA by mammalian cells exposed to single or split doses of radiation was probed with shuttle vector pZ189. Human lymphoblast hosts who received a single 120 cGy dose 2 h before transfection with 2500 cGy-damaged pZ189 yielded a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::204354755a0634e1abaf0fa2cea866d0
https://pubmed.ncbi.nlm.nih.gov/7907113
https://pubmed.ncbi.nlm.nih.gov/7907113