Zobrazeno 1 - 10
of 21
pro vyhledávání: '"M O, Diaz"'
Publikováno v:
Blood. 83:641-644
Rearrangements of chromosome band 11q23 are common in infant leukemias, comprising more than 70% of the observed chromosome abnormalities in children less than 1 year of age. The MLL gene, which is located at the 11q23 breakpoint in infant, childhood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2120efee6200787a564136f83cb2b007
https://doi.org/10.1182/blood.v83.3.641.bloodjournal833641
https://doi.org/10.1182/blood.v83.3.641.bloodjournal833641
Publikováno v:
Blood. 80:744-749
Homozygous and hemizygous deletions of the interferon A (IFNA) and IFNB genes have been frequently observed in acute leukemia cell lines, primary acute leukemia cases, and gliomas. Because IFNs have an antiproliferative effect, selection against the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4dedd8ea5812e9d75b08b951d4401b3
https://doi.org/10.1182/blood.v80.3.744.bloodjournal803744
https://doi.org/10.1182/blood.v80.3.744.bloodjournal803744
Autor:
O R Colamonici, L M Pfeffer, F D'Alessandro, L C Platanias, S A Gregory, A Rosolen, R Nordan, R A Cruciani, M O Diaz
Publikováno v:
The Journal of Immunology. 148:2126-2132
The structure of IFN-alpha receptor was studied by 1) developing antibodies against the receptor, and 2) screening a number of cell lines by affinity cross-linking to identify cells that express different IFN-alpha 2 receptor structures. We report th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e94dce29ce33edc2632f5388fdf7c7ce
https://doi.org/10.4049/jimmunol.148.7.2126
https://doi.org/10.4049/jimmunol.148.7.2126
Publikováno v:
Cancer research. 61(11)
Translocations involving the MLL gene at 11q23 are a frequent finding in therapy-related leukemia and are concentrated within a short, 8.3-kb tract of DNA, the breakpoint cluster region. In addition, a specific site adjacent to exon 12 within this re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::70cf46e5bcc7f6cb6269fc33c1d8101e
https://pubmed.ncbi.nlm.nih.gov/11389089
https://pubmed.ncbi.nlm.nih.gov/11389089
Publikováno v:
Genes, chromosomescancer. 20(4)
The MOLT-16 cell line was established from the leukemic cells of a patient with T-cell acute lymphoblastic leukemia and contains a t(8;14)(q24;q11) resulting in juxtaposition of sequences downstream of the MYC gene on chromosome 8 and the J region of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5d67b75eafec8696f2a7027c6b68c98e
https://pubmed.ncbi.nlm.nih.gov/9408752
https://pubmed.ncbi.nlm.nih.gov/9408752
Autor:
H G, Super, P L, Strissel, O M, Sobulo, D, Burian, S C, Reshmi, B, Roe, N J, Zeleznik-Le, M O, Diaz, J D, Rowley
Publikováno v:
Genes, chromosomescancer. 20(2)
The MLL gene at chromosome 11, band q23, is involved in translocations with as many as 40 different chromosomal bands. Virtually all breakpoints occur within an 8.3 kb BamHI fragment and result in 5' MLL fused to partner genes in a 5'-3' orientation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b9624c89b9915203d6d762c4c8ffcb13
https://pubmed.ncbi.nlm.nih.gov/9331569
https://pubmed.ncbi.nlm.nih.gov/9331569
Publikováno v:
Leukemia. 10(4)
The CDKN2 gene has been recently localized to a chromosomal region found to be deleted in leukemias and solid tumors. CDKN2 encodes a 16 kDa protein product (p16INK4A), which functions as a specific inhibitor or the cyclin-dependent kinases 4 and 6.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cf32ad0e0e518b2b7fac4b0264b8a04a
https://pubmed.ncbi.nlm.nih.gov/8618438
https://pubmed.ncbi.nlm.nih.gov/8618438
Autor:
O R, Colamonici, B, Porterfield, P, Domanski, R K, Handa, S, Flex, C E, Samuel, R, Pine, M O, Diaz
Publikováno v:
The Journal of biological chemistry. 269(44)
Two interferon (IFN) alpha-regulated genes, IRF1/ISGF2 and PKR/p68 kinase, may function as tumor suppressor genes suggesting that the IFN system may function as a tumor suppressor system. We report that the expression of the alpha subunit of the type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6577dd57c5f672dc9446398fe2bbb6b5
https://pubmed.ncbi.nlm.nih.gov/7961637
https://pubmed.ncbi.nlm.nih.gov/7961637
Autor:
W, Stock, M J, Thirman, R K, Dodge, J D, Rowley, M O, Diaz, D, Wurster-Hill, R E, Sobol, F R, Davey, R A, Larson, C A, Westbrook
Publikováno v:
Leukemia. 8(11)
Specific structural rearrangements involving chromosome band 11q23 occur in a variety of hematologic malignancies, including an estimated 2-7% of patients with acute lymphoblastic leukemia (ALL). Translocations involving chromosome band 11q23 have be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::62a85e2ea43671e37053d17b014d32e9
https://pubmed.ncbi.nlm.nih.gov/7967737
https://pubmed.ncbi.nlm.nih.gov/7967737
Publikováno v:
Blood. 84(4)
Previously we had characterized the t(1;7)(p34;q34) translocation from HSB-2. This translocation fused the beta T-cell receptor gene (TCRB) constant region and transcriptional enhancer with the type I transcription unit of the LCK gene on the derivat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3ffc7f11656817141790a9506899b2ca
https://pubmed.ncbi.nlm.nih.gov/8049439
https://pubmed.ncbi.nlm.nih.gov/8049439