Zobrazeno 1 - 10
of 2 114
pro vyhledávání: '"M Neal"'
Autor:
Holly C May, Jieh-Juen Yu, Hao Zhang, Yufeng Wang, Andrew P Cap, James P Chambers, M Neal Guentzel, Bernard P Arulanandam
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0218505 (2019)
The Gram-negative pathogen, Acinetobacter baumannii has emerged as a global nosocomial health threat affecting the majority of hospitals in the U.S. and abroad. The redox protein thioredoxin has been shown to play several roles in modulation of cellu
Externí odkaz:
https://doaj.org/article/f0277587ce5849879d3271de32865c51
Publikováno v:
eLife, Vol 7 (2018)
Many important gram-negative bacterial pathogens use highly sophisticated type III protein secretion systems (T3SSs) to establish complex host-pathogen interactions. Bacterial-host cell contact triggers the activation of the T3SS and the subsequent i
Externí odkaz:
https://doaj.org/article/f8aaa47726e840b89f5023b34237fda5
Publikováno v:
PLoS Biology, Vol 16, Iss 9, p e2006169 (2018)
Neurons project axons to local and distal sites and can display heterogeneous morphologies with limited physical dimensions that may influence the structure of large organelles such as mitochondria. Using cryo-electron tomography (cryo-ET), we charac
Externí odkaz:
https://doaj.org/article/4874eaae02864f398b2dadf56ff2ca0a
Autor:
Aimee L Cunningham, M Neal Guentzel, Jieh-Juen Yu, Chiung-Yu Hung, Thomas G Forsthuber, Christopher S Navara, Hideo Yagita, Ifor R Williams, Karl E Klose, Tonyia D Eaves-Pyles, Bernard P Arulanandam
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153402 (2016)
M-cells (microfold cells) are thought to be a primary conduit of intestinal antigen trafficking. Using an established neutralizing anti-RANKL (Receptor Activator of NF-κB Ligand) antibody treatment to transiently deplete M-cells in vivo, we sought t
Externí odkaz:
https://doaj.org/article/310d753c5dd54431bca5d5ea74eff47e
Autor:
Shradha Wali, Rishein Gupta, Ronald L Veselenak, Yansong Li, Jieh-Juen Yu, Ashlesh K Murthy, Andrew P Cap, M Neal Guentzel, James P Chambers, Guangming Zhong, Roger G Rank, Richard B Pyles, Bernard P Arulanandam
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114261 (2014)
Guinea pigs have been used as a second animal model to validate putative anti-chlamydial vaccine candidates tested in mice. However, the lack of guinea pig-specific reagents has limited the utility of this animal model in Chlamydia sp. vaccine studie
Externí odkaz:
https://doaj.org/article/39edd571e0464c3eb0f118ba2a8f5bdc
Publikováno v:
In Biophysical Journal 3 September 2024 123(17):2877-2891
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 7, p e1002114 (2011)
The flexibility in the structure of calmodulin (CaM) allows its binding to over 300 target proteins in the cell. To investigate the structure-function relationship of CaM, we combined methods of computer simulation and experiments based on circular d
Externí odkaz:
https://doaj.org/article/6edcb134dcbb4612b37be7704b0fa8fe
Autor:
Kalyan C Nallaparaju, Jieh-Juen Yu, Stephen A Rodriguez, Xhavit Zogaj, Srikanth Manam, M Neal Guentzel, Janakiram Seshu, Ashlesh K Murthy, James P Chambers, Karl E Klose, Bernard P Arulanandam
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e18201 (2011)
Francisella tularensis is a Gram-negative facultative intracellular bacterium and the causative agent of the lethal disease tularemia. An outer membrane protein (FTT0918) of F. tularensis subsp. tularensis has been identified as a virulence factor. W
Externí odkaz:
https://doaj.org/article/389778b9c886473bb9bd8b0caffeb8f3
Autor:
Ashlesh K Murthy, Bharat K R Chaganty, Ty Troutman, M Neal Guentzel, Jieh-Juen Yu, Syed Khalid Ali, Crystal M Lauriano, James P Chambers, Karl E Klose, Bernard P Arulanandam
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e16847 (2011)
The role of antigen-specific secretory IgA (SIgA) has been studied extensively, whereas there is a limited body of evidence regarding the contribution of non-specific SIgA to innate immune defenses against invading pathogens. In this study, we evalua
Externí odkaz:
https://doaj.org/article/f4c9ceab86144e1dbd472d3850f8ab82
Autor:
Yoshihisa Kubota, M Neal Waxham
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 11, p e1000987 (2010)
Calmodulin (CaM) is a ubiquitous Ca(2+) buffer and second messenger that affects cellular function as diverse as cardiac excitability, synaptic plasticity, and gene transcription. In CA1 pyramidal neurons, CaM regulates two opposing Ca(2+)-dependent
Externí odkaz:
https://doaj.org/article/f56f3c75631a41ce8f618b1626fba3f8