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Reactions with pyrrolidine-2,4-diones, Part 4: Synthesis of some 3-substituted 1,5-diphenylpyrrolidine-2,4-diones as potential antimicrobial, anti-HIV-1 and antineoplastic agents

Autor: S A, Shams el-Dine, F S, Soliman, F A, Ashour, M N, Saudi

Publikováno v: Die Pharmazie. 56(12)

The condensation of 1,5-diphenylpyrrolidine-2,4-dione (1) with ethyl orthoformate yielded 3-ethoxymethylene-1,5-diphenylpyrrolidine-2,4-dione (2). Reaction of the latter with hydrazine hydrate, secondary amines 7a-c or urea afforded the corresponding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6e6a22b62c73eced16572a075e58e7d1
https://pubmed.ncbi.nlm.nih.gov/11802654

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Reactions with pyrrolidine-2,4-diones, III (1). Synthesis of some substituted 3-pyrrolin-2-ones and 4-hydrazonopyrrolidin-2-ones as potential antineoplastic and antimicrobial agents

Autor: S A, el-Dine, M G, Kassem, F S, Soliman, M N, Saudi, O, Kader

Publikováno v: Farmaco (Societa chimica italiana : 1989). 46(10)

The syntheses of 3-bromo-, 3-substituted aminomethyl-, and 3-(4-substituted sulfamylphenylazo)-4-hydroxy-1,5-diphenyl-pyrrolin-2-ones 4,6 and 8 from 1,5-diphenylpyrrolidine-2,4-dione 3 via bromination aminomethylation and diazocoupling, respectively,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ce6afd53daba3afa26e82cba256f0697
https://pubmed.ncbi.nlm.nih.gov/1815580

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