Zobrazeno 1 - 10
of 14
pro vyhledávání: '"M N, Muscará"'
Autor:
E, Ekundi-Valentim, K T, Santos, E A, Camargo, A, Denadai-Souza, S A, Teixeira, C I, Zanoni, A D, Grant, Jl, Wallace, M N, Muscará, S K, Costa
Publikováno v:
British journal of pharmacology. 159(7)
Recent findings suggest that the noxious gas H(2)S is produced endogenously, and that physiological concentrations of H(2)S are able to modulate pain and inflammation in rodents. This study was undertaken to evaluate the ability of endogenous and exo
Autor:
R E, Barrientos-Astigarraga, Y B, Vannuchi, M, Sucupira, R A, Moreno, M N, Muscará, G, De Nucci
Publikováno v:
Journal of mass spectrometry : JMS. 36(12)
A method based on liquid chromatography with negative ion electrospray ionization and tandem mass spectrometry is described for the determination of nimesulide in human plasma. Liquid-liquid extraction using a mixture of diethyl ether and dichloromet
Publikováno v:
British journal of pharmacology. 133(8)
1. Nonsteroidal anti-inflammatory drugs have been reported to exacerbate hypertension and to interfere with the effectiveness of some anti-hypertensive therapies. In this study, we tested the effects of a gastric-sparing, nitric oxide-releasing deriv
Publikováno v:
British journal of pharmacology. 129(7)
1. Selective inhibitors of cyclo-oxygenase-2 have been shown to be effective anti-inflammatory drugs with reduced gastrointestinal toxicity relative to conventional nonsteroidal anti-inflammatory drugs (NSAIDs). In the present study, we examined the
Publikováno v:
British journal of pharmacology. 129(4)
Selective cyclo-oxygenase (COX)-2 inhibitors and nitric oxide-releasing nonsteroidal anti-inflammatory drugs (NSAIDs) exhibit reduced toxicity in the gastrointestinal tract, but may affect wound healing in other tissues. In this study, we have compar
Autor:
C M, Da Silva, F L, David, M N, Muscará, S S, Sousa, J G, Ferraz, G, De Nucci, N C, Polimeno, J, Pedrazzoli
Publikováno v:
Alimentary pharmacologytherapeutics. 13(10)
To evaluate the usefulness of plasma hydroxy-metronidazole/metronidazole (OH-MET/MET) ratios as a dynamic liver function test in ethanol abusers with or without liver cirrhosis.Metronidazole was administered intravenously for 20 min to healthy volunt
Autor:
M N, Muscará, J L, Wallace
Publikováno v:
The American journal of physiology. 276(6)
Nitric oxide is a crucial mediator of gastrointestinal mucosal defense, but, paradoxically, it also contributes to mucosal injury in several situations. Inhibitors of nitric oxide synthesis and compounds that release nitric oxide have been useful pha
Autor:
C E, Teixeira, A C, Bento, R A, Lopes-Martins, S A, Teixeira, V, von Eickestedt, M N, Muscará, E C, Arantes, J R, Giglio, E, Antunes, G, de Nucci
Publikováno v:
British journal of pharmacology. 123(3)
1. The effect of Tityus serrulatus scorpion venom and its toxin components on the rabbit isolated corpus cavernosum was investigated by use of a bioassay cascade. 2. Tityus serrulatus venom (3-100 microg), acetylcholine (ACh; 0.3-30 nmol) and glycery
Publikováno v:
European journal of clinical pharmacology. 50(5)
Two different conventional release enalapril maleate tablet formulations were evaluated for their relative bioavailability (Eupressin tablets 10 mg, Biosintética as the test formulation vs Renitec tablets 10 mg Merck SharpDhome, as the reference for
Autor:
M N, Muscará, G, de Nucci
Publikováno v:
International journal of clinical pharmacology and therapeutics. 33(1)
The bioavailability of two tablet formulations of cetirizine (Zetir from Abbott and Zyrtek from UCB) were compared in 14 healthy male volunteers who received a single dose of 10 mg of cetirizine dihydrochloride in an open randomized two-period crosso