Zobrazeno 1 - 10
of 178
pro vyhledávání: '"M N, Makarova"'
Publikováno v:
Регуляторные исследования и экспертиза лекарственных средств, Vol 14, Iss 4, Pp 448-462 (2024)
INTRODUCTION. The determination of nephrotoxicity markers is a useful and necessary step in the detection of renal injury in animal experiments; these markers help accurately localise organ damage. With multiple damaging agents, known nephrotoxicity
Externí odkaz:
https://doaj.org/article/53d85317f6654e4db4c4d6e44419c5c7
Publikováno v:
Регуляторные исследования и экспертиза лекарственных средств, Vol 14, Iss 3, Pp 283-294 (2024)
INTRODUCTION. Functional examination of the urinary system, and particularly the kidneys, is an important challenge in preclinical studies. Currently, there is no generally recognised and detailed approach to drug-induced nephrotoxicity detection in
Externí odkaz:
https://doaj.org/article/b88b40828e534149bc065f76e570bfcb
Autor:
M. N. Makarova
Publikováno v:
Регуляторные исследования и экспертиза лекарственных средств, Vol 14, Iss 3, Pp 248-250 (2024)
The ultimate goal of preclinical studies is to generate data that can be used to make conclusions about the potential effects of a new medicine on the human body and to properly proceed to clinical trials. In this interview, Marina N. Makarova, Docto
Externí odkaz:
https://doaj.org/article/e2766adae58a4bdaade9621b93edfe81
Autor:
V. M. Kosman, M. V. Karlina, V. A. Vavilova, K. E. Borovkova, K. L. Kryshen, N. V. Marchenko, S. A. Kopatko, I. V. Sychkova, D. R. Kargopoltseva, M. N. Makarova, V. G. Makarov
Publikováno v:
Безопасность и риск фармакотерапии, Vol 12, Iss 1, Pp 83-98 (2024)
SCIENTIFIC RELEVANCE. The high prevalence of fungal skin infections motivates expanding the range of sertaconazole products for external use.AIM. The study was a preclinical comparison of the safety, antifungal activity, and pharmacokinetics of Serta
Externí odkaz:
https://doaj.org/article/005982f3fa524854ac95cc9d897c54e7
Autor:
N. L. Polyuga, E. I. Trofimets, K. E. Borovkova, L. R. Nikiforova, Ju. V. Salmova, A. A. Peleshok, K. L. Kryshen, M. N. Makarova, A. M. Kolodkin, D. E. Mitereva, I. S. Kasatkina
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 3, Pp 39-49 (2023)
Relevance. Under the influence of endogenous and /or exogenous factors, the intestinal microflora inhabiting all parts of the gastrointestinal tract may change, which disrupts the normal course of physiological processes, and in some cases leads to
Externí odkaz:
https://doaj.org/article/241fc2af58ab4ef184d1c09f6d133b5a
Autor:
V. M. Kosman, M. V. Karlina, E. V. Mazukina, A. A. Globenko, E. A. Jain, M. N. Makarova, V. G. Makarov
Publikováno v:
Безопасность и риск фармакотерапии, Vol 11, Iss 2, Pp 176-190 (2023)
Esomeprazole, the S-isomer of omeprazole, is a second-generation proton pump inhibitor widely used for acid-related diseases of the oesophagus, stomach, and duodenum (peptic ulcer, gastro-oesophageal reflux disease, etc.). Studies on esomeprazole saf
Externí odkaz:
https://doaj.org/article/4ff69e0a81ad4e8e9858ccb8df76c723
Publikováno v:
Безопасность и риск фармакотерапии, Vol 11, Iss 2, Pp 191-203 (2023)
Several treatment regimens with antituberculosis medicinal products are available for tuberculosis. Thiozonide is a newly developed original antimicrobial agent that exhibits bacteriostatic activity against Mycobacterium tuberculosis strains H37Rv, C
Externí odkaz:
https://doaj.org/article/7d0f4967f53048838d69d12e030f0abb
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 12, Iss 2, Pp 155-163 (2023)
Introduction. Pharmaceutical development of an innovative highly effective and competitive drug is a long and expensive process, the result of which is quite difficult to predict in advance. To speed up the entry of a new drug to the treatment and re
Externí odkaz:
https://doaj.org/article/1369a2d9dddd406e8e86b38b08a7c1c4
Publikováno v:
Регуляторные исследования и экспертиза лекарственных средств, Vol 13, Iss 1, Pp 27-41 (2023)
The endocrine system coordinates almost all organs and other systems in vertebrates. In particular, it regulates such important biological functions as metabolism, development, reproduction, and behaviour. To date, a significant amount of information
Externí odkaz:
https://doaj.org/article/13de28c2fa4b48d3a4a42f0645eab822
Autor:
N. M. Faustova, S. S. Petlitskaya, I. N. Ampilogova, M. V. Karlina, M. N. Makarova, V. G. Makarov
Publikováno v:
Регуляторные исследования и экспертиза лекарственных средств, Vol 13, Iss 1, Pp 60-76 (2023)
Neuraminidase inhibitors are a class of antivirals used to treat influenza infections. Screening assays for potential neuraminidase inhibitors would benefit from the development of in vitro procedures that do not require handling viruses. The aim of
Externí odkaz:
https://doaj.org/article/2a9e3bd608224f3e8433f0fb374c3e13