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Cytoplasmic Localization of Endothelial Constitutive Nitric Oxide Synthase in Endometrial Carcinomas

Autor: David G. Hanson, Brandon G. Bentz, James A. Radosevich, G.K. Haines, John R. Lurain, M. N. Barnes

Publikováno v: Tumor Biology. 18:290-300

Production of nitric oxide by nitric oxide synthase (NOS) has been implicated in numerous physiologic and pathophysiologic processes including mutagenesis. This study was designed to examine the expression of the endothelial constitutive isoform of N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa9802847fa48f69c24a9b6ce66e5895
https://doi.org/10.1159/000218042

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Strategies to accomplish targeted expression of transgenes in ovarian cancer for molecular therapeutic applications

Autor: E, Casado, J, Gomez-Navarro, M, Yamamoto, Y, Adachi, C J, Coolidge, W O, Arafat, S D, Barker, M H, Wang, P J, Mahasreshti, A, Hemminki, M, Gonzalez-Baron, M N, Barnes, T B, Pustilnik, G P, Siegal, R D, Alvarez, D T, Curiel

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 7(8)

The purpose of the study was to determine the capability of the midkine (MK) and cycooxygenase-2 (cox-2) gene promoter regions to function as tumor-specific promoters for use in targeted gene therapy of ovarian cancer.Established and primary ovarian

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1b5b854f4087b3127d05eb57a83dae43
https://pubmed.ncbi.nlm.nih.gov/11489832

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Adenovirus-mediated soluble FLT-1 gene therapy for ovarian carcinoma

Autor: P J, Mahasreshti, J G, Navarro, M, Kataram, M H, Wang, D, Carey, G P, Siegal, M N, Barnes, D M, Nettelbeck, R D, Alvarez, A, Hemminki, D T, Curiel

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 7(7)

We hypothesized that adenovirus-mediated soluble fms-like tyrosine kinase receptor (sFLT-1) gene therapy can inhibit the ovarian tumor growth and increase survival of mice in the context of ovarian carcinoma.We constructed an infectivity-enhanced rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f4e2ed6748c03f95951de9bff87364ac
https://pubmed.ncbi.nlm.nih.gov/11448924

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Selectivity of TAG-72-targeted adenovirus gene transfer to primary ovarian carcinoma cells versus autologous mesothelial cells in vitro

Autor: F J, Kelly, C R, Miller, D J, Buchsbaum, J, Gomez-Navarro, M N, Barnes, R D, Alvarez, D T, Curiel

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 6(11)

Efficient gene transfer by recombinant adenovirus (Ad) vectors depends on expression of CAR and alpha(v) integrin on target cells. Because Ad may also infect nearby nontarget cells expressing these receptors, such as peritoneal mesothelial cells afte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b7c8bbd586e716de3b24c3f725ece24d
https://pubmed.ncbi.nlm.nih.gov/11106250

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A cancer gene therapy approach utilizing an anti-erbB-2 single-chain antibody-encoding adenovirus (AD21): a phase I trial

Autor: R D, Alvarez, M N, Barnes, J, Gomez-Navarro, M, Wang, T V, Strong, W, Arafat, R B, Arani, M R, Johnson, B L, Roberts, G P, Siegal, D T, Curiel

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 6(8)

The purpose of this Phase I study was to determine the feasibility of using an anti-erbB-2-encoding adenovirus (Ad21) to treat erbB-2-overexpressing ovarian cancer. Recurrent ovarian cancer patients were treated i.p. with Ad21 in dosages ranging from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4ce1c3336193692070aad1ba0131f095
https://pubmed.ncbi.nlm.nih.gov/10955787

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Gene therapy for ovarian carcinoma

Autor: M W, Robertson, M N, Barnes, C, Rancourt, M, Wang, J, Grim, R D, Alvarez, G P, Siegal, D T, Curiel

Publikováno v: Seminars in oncology. 25(3)

Originally conceived and applied for the treatment of inherited monogenetic defects such as adenosine deaminase deficiency and cystic fibrosis, gene therapy was later applied to the treatment of cancer. Such a genetic strategy seemed rational given t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::51adcd6f25e379b0d695f664bae81d08
https://pubmed.ncbi.nlm.nih.gov/9633852

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Gene therapy and ovarian cancer: a review

Autor: M N, Barnes, J S, Deshane, M, Rosenfeld, G P, Siegal, D T, Curiel, R D, Alvarez

Publikováno v: Obstetrics and gynecology. 89(1)

To provide the obstetrician-gynecologist with the basic concepts of gene therapy, an overview of cancer gene therapy treatment strategies, and a summary of currently approved human gene therapy protocols for ovarian carcinoma.A computerized search of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::99dfb8942eae50c237bf7693b75a0213
https://pubmed.ncbi.nlm.nih.gov/8990458

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Novel gene therapy strategy to accomplish growth factor modulation induces enhanced tumor cell chemosensitivity

Autor: M N, Barnes, J S, Deshane, G P, Siegal, R D, Alvarez, D T, Curiel

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 2(7)

erbB-2 is a cell surface transmembrane glycoprotein which, when overexpressed, has been shown to be relevant to intrinsic tumor cell chemoresistance. Thus, strategies to down-regulate cell surface erbB-2 have resulted in enhanced tumor cell chemosens

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::41b6fdb527e677a557f5b2c36a8b61b8
https://pubmed.ncbi.nlm.nih.gov/9816272

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