Zobrazeno 1 - 10
of 27
pro vyhledávání: '"M Morgan Conn"'
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 6, Iss 1, p 5 (2010)
We present here the design, synthesis, and analysis of a series of receptors for peptide ligands inspired by the hydrogen-bonding pattern of protein β-sheets. The receptors themselves can be regarded as strands 1 and 3 of a three-stranded β-sheet,
Externí odkaz:
https://doaj.org/article/a0493b21b95b4755825066909f6c2bc4
Autor:
James J. Takasugi, Anna Mollin, Jeffrey Allen Campbell, Meenal Patel, Shirley Yeh, Stuart W. Peltz, Yuki Tomizawa, Young-Choon Moon, Ellen Welch, Allan Jacobson, Gary Mitchell Karp, Huisheng Feng, Anthony Turpoff, Hongyu Ren, Jin Zhuo, S. M. Jones, Atiyya Khan, Valerie Northcutt, Neil G. Almstead, Arthur Branstrom, Feng He, M. Morgan Conn, Guangming Chen, William D. Ju, Wilde Richard Gerald, Samit Hirawat, Christopher R. Trotta, Masataka Kawana, Nicole Risher, Sergey Paushkin, Seongwoo Hwang, Joseph M. Colacino, H. Lee Sweeney, Donald Thomas Corson, Phyllis Spatrick, Elisabeth R. Barton, Panayiota Trifillis, Langdon L. Miller, Westley J. Friesen, Marla Weetall, John Babiak, Jean Hedrick
Publikováno v:
Nature. 447:87-91
Nonsense mutations promote premature translational termination and cause anywhere from 5-70% of the individual cases of most inherited diseases. Studies on nonsense-mediated cystic fibrosis have indicated that boosting specific protein synthesis from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::842e3830493226719ef5b397161007f5
https://doi.org/10.1038/nature05756
https://doi.org/10.1038/nature05756
Autor:
Joe Kappock, Nicola Pohl, Richard Cammack, M Morgan Conn, Dennis Hall, Tony Cass, Jon D Stewart, Graham RL Cousins, Jeremy KM Sanders, Sabine Flitsch, Philip AS Lowden, Richard Newman
Publikováno v:
Current Opinion in Chemical Biology. 4:357-366
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b1f36e6230b795de5a1fe1dce67b3f0
https://doi.org/10.1016/s1367-5931(00)00115-0
https://doi.org/10.1016/s1367-5931(00)00115-0
Autor:
Sabine L. Flitsch, Richard Cammack, Tony Cass, Joe Kappock, Dale G. Drueckhammer, Jon D. Stewart, Graham R. L. Cousins, Philip A.S Lowden, M Morgan Conn, Dennis G. Hall, Richard Newman, Jeremy K. M. Sanders
Publikováno v:
Current Opinion in Chemical Biology. 3:631-638
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51f8dc7c34b5fa60a40fba8a3c293209
https://doi.org/10.1016/s1367-5931(99)00038-1
https://doi.org/10.1016/s1367-5931(99)00038-1
Publikováno v:
Proceedings of the National Academy of Sciences. 92:1208-1212
Four water-soluble adenine receptors were synthesized to study the influence of hydrophobic interactions and hydrogen bonding on molecular recognition in aqueous solution. Association constants were measured in aqueous solution at five temperatures f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15922a7a76f0ad303ca9c01fe87f8634
https://doi.org/10.1073/pnas.92.4.1208
https://doi.org/10.1073/pnas.92.4.1208
Publikováno v:
Journal of the American Chemical Society. 116:8877-8884
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c76a521bef7ec8e2dcd2347d7c509dd
https://doi.org/10.1021/ja00099a003
https://doi.org/10.1021/ja00099a003
Publikováno v:
Accounts of Chemical Research. 27:198-203
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8cd041cb0ec05c50801f4018ce8884d
https://doi.org/10.1021/ar00043a003
https://doi.org/10.1021/ar00043a003
Publikováno v:
Journal of the American Chemical Society. 116:3279-3284
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32325a0a6f1b13b38fef504aa898217c
https://doi.org/10.1021/ja00087a013
https://doi.org/10.1021/ja00087a013
Autor:
Julius Rebek, M. Morgan Conn
Publikováno v:
Current Opinion in Structural Biology. 4:629-635
The relevance of autocatalysis to the molecular origins of biological metabolism is discussed as well as important considerations for the design of ‘self-replicating’ molecules. Typically, the source of autocatalysis is the template effect. DNA h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da12f7b05934b1bab8e75de2b8cddaa4
https://doi.org/10.1016/s0959-440x(94)90229-1
https://doi.org/10.1016/s0959-440x(94)90229-1
Publikováno v:
Journal of the American Chemical Society. 115:3548-3557
Receptors based upon 3,6-diaminocarbazole have been synthesized that bind to adenosine derivatives with an interaction energy of approximately 8 kcal/mol in CDCl 3 and over 3 kcal/mol in CD 3 OD. The purine nucleus is bound within a cavity by simulta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0535dfb1f305dc6ae31b7047bc30dcc0
https://doi.org/10.1021/ja00062a020
https://doi.org/10.1021/ja00062a020