Zobrazeno 1 - 10 of 1 292 pro vyhledávání: '"M Mignogna"'
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Akademický článek
Cross-species alcohol dependence-associated gene networks: Co-analysis of mouse brain gene expression and human genome-wide association data.
Autor: Kristin M Mignogna, Silviu A Bacanu, Brien P Riley, Aaron R Wolen, Michael F Miles
Publikováno v: PLoS ONE, Vol 14, Iss 4, p e0202063 (2019)
Genome-wide association studies on alcohol dependence, by themselves, have yet to account for the estimated heritability of the disorder and provide incomplete mechanistic understanding of this complex trait. Integrating brain ethanol-responsive gene
Externí odkaz: https://doaj.org/article/0ea67ab44f044813ac8eab92e14b6e8f
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3
Genetic Mapping of Progressive Ethanol Consumption in the Diversity Outbred Mouse
Autor: Zachary Tatom, Kristin M. Mignogna, Zachary Sergi, Jeremy Nguyen, Marie Michenkova, Maren L. Smith, Michael F. Miles
Traditional genetic mapping studies using inbred crosses are a powerful tool for identifying chromosomal regions associated with ethanol-related traits, but typically have very large confidence intervals which make identification of specific and pote
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d2947bce9e27b2f8f304574fee5fd7f9
https://doi.org/10.1101/2022.12.06.519344
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4
Akademický článek
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5
Characterizing the longitudinal course of symptoms and functioning in bipolar disorder
Autor: Kristin M. Mignogna, Fernando S. Goes
Publikováno v: Psychological medicine.
Background The course of Bipolar Disorder (BD) is highly variable, with marked inter and intra-individual differences in symptoms and functioning. In this study, we identified illness trajectories across major clinical domains that could have etiolog
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2246219799b4cc24eee5ab93a61c0c69
https://pubmed.ncbi.nlm.nih.gov/35699120
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7
Beyond genome-wide significance: integrative approaches to the interpretation and extension of GWAS findings for alcohol use disorder
Autor: Sean P. Farris, Michael F. Miles, Shizhong Han, Arpana Agrawal, Kristin M. Mignogna, Jessica E. Salvatore
Publikováno v: Addiction Biology. 24:275-289
Alcohol use disorder (AUD) is a heritable complex behavior. Due to the highly polygenic nature of AUD, identifying genetic variants that comprise this heritable variation has proved to be challenging. With the exception of functional variants in alco
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96dae706bc0333000eb9d65bad064233
https://doi.org/10.1111/adb.12591
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10
CROSS-SPECIES ANALYSIS OF ALCOHOL-REGULATED AND DEPENDENCE-ASSOCIATED GENE NETWORKS IN THE VENTRAL TEGMENTAL AREA
Autor: Kristin M. Mignogna, Michael F. Miles, Aaron R. Wolen, Brien P. Riley, Silviu Alin Bacanu
Publikováno v: European Neuropsychopharmacology. 29:S880-S881
Background Despite studies suggesting that Alcohol Dependence (AD) is moderately heritable, Genome-Wide Association Studies (GWAS) on AD lack power for detecting the small contribution of individual genes to risk, and the ability to determine their m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a804fd9e19a45b6f668e940ef3bb998
https://doi.org/10.1016/j.euroneuro.2017.08.181
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