Zobrazeno 1 - 10
of 98
pro vyhledávání: '"M Margarita Behrens"'
Autor:
Junhao Li, Antonio Pinto-Duarte, Mark Zander, Michael S Cuoco, Chi-Yu Lai, Julia Osteen, Linjing Fang, Chongyuan Luo, Jacinta D Lucero, Rosa Gomez-Castanon, Joseph R Nery, Isai Silva-Garcia, Yan Pang, Terrence J Sejnowski, Susan B Powell, Joseph R Ecker, Eran A Mukamel, M Margarita Behrens
Publikováno v:
eLife, Vol 11 (2022)
Two epigenetic pathways of transcriptional repression, DNA methylation and polycomb repressive complex 2 (PRC2), are known to regulate neuronal development and function. However, their respective contributions to brain maturation are unknown. We foun
Externí odkaz:
https://doaj.org/article/2b19661e6d424d7f80090d1c7628e4de
Autor:
Laura A Lavery, Kerstin Ure, Ying-Wooi Wan, Chongyuan Luo, Alexander J Trostle, Wei Wang, Haijing Jin, Joanna Lopez, Jacinta Lucero, Mark A Durham, Rosa Castanon, Joseph R Nery, Zhandong Liu, Margaret Goodell, Joseph R Ecker, M Margarita Behrens, Huda Y Zoghbi
Publikováno v:
eLife, Vol 9 (2020)
Methylated cytosine is an effector of epigenetic gene regulation. In the brain, Dnmt3a is the sole ‘writer’ of atypical non-CpG methylation (mCH), and MeCP2 is the only known ‘reader’ for mCH. We asked if MeCP2 is the sole reader for Dnmt3a d
Externí odkaz:
https://doaj.org/article/b078fc09c47f4ff18e2e3557478a806d
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193446 (2018)
Reduced expression of Sp4, the murine homolog of human SP4, a risk gene of multiple psychiatric disorders, led to N-methyl-D-aspartate (NMDA) hypofunction in mice, producing behavioral phenotypes reminiscent of schizophrenia, including hypersensitivi
Externí odkaz:
https://doaj.org/article/b6525905542243a3a38a9001159a5e74
Autor:
Laura L Dugan, Sameh S Ali, Grigoriy Shekhtman, Amanda J Roberts, Jacinta Lucero, Kevin L Quick, M Margarita Behrens
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5518 (2009)
BACKGROUND:Multiple studies have shown that plasma levels of the pro-inflammatory cytokine interleukin-6 (IL-6) are elevated in patients with important and prevalent adverse health conditions, including atherosclerosis, diabetes, obesity, obstructive
Externí odkaz:
https://doaj.org/article/d8ae3ad7173140d49ddf468a74182ed5
Autor:
Dionisio A. Amodeo, Chi-Yu Lai, Omron Hassan, Eran A. Mukamel, M. Margarita Behrens, Susan B. Powell
Publikováno v:
Neurobiology of Disease, Vol 125, Iss , Pp 211-218 (2019)
Background: Epidemiological studies suggest that the risk of neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia is increased by prenatal exposure to viral or bacterial infection during pregnancy. It is still unclear
Externí odkaz:
https://doaj.org/article/166789100d554114873db0298dceda76
Autor:
Jingtian Zhou, Zhuzhu Zhang, May Wu, Hanqing Liu, Yan Pang, Anna Bartlett, Angeline Rivkin, Will N. Lagos, Elora Williams, Cheng-Ta Lee, Paula Assakura Miyazaki, Andrew Aldridge, Qiurui Zeng, J.L. Angelo Salinda, Naomi Claffey, Michelle Liem, Conor Fitzpatrick, Lara Boggeman, Zizhen Yao, Kimberly A. Smith, Bosiljka Tasic, Jordan Altshul, Mia A. Kenworthy, Cynthia Valadon, Joseph R. Nery, Rosa G. Castanon, Neelakshi S. Patne, Minh Vu, Mohammad Rashid, Matthew Jacobs, Tony Ito, Julia Osteen, Nora Emerson, Jasper Lee, Silvia Cho, Jon Rink, Hsiang-Hsuan Huang, António Pinto-Duartec, Bertha Dominguez, Jared B. Smith, Carolyn O’Connor, Hongkui Zeng, Kuo-Fen Lee, Eran A. Mukamel, Xin Jin, M. Margarita Behrens, Joseph R. Ecker, Edward M. Callaway
Single-cell genetic and epigenetic analyses parse the brain’s billions of neurons into thousands of “cell-type” clusters, each residing in different brain structures. Many of these cell types mediate their unique functions by virtue of targeted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9be68f59326b0f760b9c918401ade8a
https://doi.org/10.1101/2023.05.01.538832
https://doi.org/10.1101/2023.05.01.538832
Autor:
Hanqing Liu, Qiurui Zeng, Jingtian Zhou, Anna Bartlett, Bang-An Wang, Peter Berube, Wei Tian, Mia Kenworthy, Jordan Altshul, Joseph R. Nery, Huaming Chen, Rosa G. Castanon, Songpeng Zu, Yang Eric Li, Jacinta Lucero, Julia K. Osteen, Antonio Pinto-Duarte, Jasper Lee, Jon Rink, Silvia Cho, Nora Emerson, Michael Nunn, Carolyn O’Connor, Zizhen Yao, Kimberly A. Smith, Bosiljka Tasic, Hongkui Zeng, Chongyuan Luo, Jesse R. Dixon, Bing Ren, M. Margarita Behrens, Joseph R Ecker
Publikováno v:
bioRxiv
Cytosine DNA methylation is essential in brain development and has been implicated in various neurological disorders. A comprehensive understanding of DNA methylation diversity across the entire brain in the context of the brain’s 3D spatial organi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc456672ce91c913abcd0b3c00701b9f
https://europepmc.org/articles/PMC10153407/
https://europepmc.org/articles/PMC10153407/
Autor:
Wei Tian, Jingtian Zhou, Anna Bartlett, Qiurui Zeng, Hanqing Liu, Rosa G. Castanon, Mia Kenworthy, Jordan Altshul, Cynthia Valadon, Andrew Aldridge, Joseph R. Nery, Huaming Chen, Jiaying Xu, Nicholas D. Johnson, Jacinta Lucero, Julia K. Osteen, Nora Emerson, Jon Rink, Jasper Lee, Yang Li, Kimberly Siletti, Michelle Liem, Naomi Claffey, Caz O’Connor, Anna Marie Yanny, Julie Nyhus, Nick Dee, Tamara Casper, Nadiya Shapovalova, Daniel Hirschstein, Rebecca Hodge, Boaz P. Levi, C. Dirk Keene, Sten Linnarsson, Ed Lein, Bing Ren, M. Margarita Behrens, Joseph R. Ecker
Delineating the gene regulatory programs underlying complex cell types is fundamental for understanding brain functions in health and disease. Here, we comprehensively examine human brain cell epigenomes by probing DNA methylation and chromatin confo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86f1a55844637c45d014151ad5d55429
https://doi.org/10.1101/2022.11.30.518285
https://doi.org/10.1101/2022.11.30.518285
Autor:
Yang Eric Li, Sebastian Preissl, Michael Miller, Nicholas D. Johnson, Zihan Wang, Henry Jiao, Chenxu Zhu, Zhaoning Wang, Yang Xie, Olivier Poirion, Colin Kern, Antonio Pinto-Duarte, Wei Tian, Kimberly Siletti, Nora Emerson, Julia Osteen, Jacinta Lucero, Lin Lin, Qian Yang, Quan Zhu, Sarah Espinoza, Anna Marie Yanny, Julie Nyhus, Nick Dee, Tamara Casper, Nadiya Shapovalova, Daniel Hirschstein, Rebecca D. Hodge, Sten Linnarsson, Trygve Bakken, Boaz Levi, C. Dirk Keene, Jingbo Shang, Ed S. Lein, Allen Wang, M. Margarita Behrens, Joseph R. Ecker, Bing Ren
The human brain contains an extraordinarily diverse set of neuronal and glial cell types. Recent advances in single cell transcriptomics have begun to delineate the cellular heterogeneity in different brain regions, but the transcriptional regulatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74589a98d6c67c1c33d192859f28ce92
https://doi.org/10.1101/2022.11.09.515833
https://doi.org/10.1101/2022.11.09.515833
Autor:
Antonio Pinto-Duarte, Junhao Li, Mark Zander, Michael S Cuoco, Chi-Yu Lai, Julia Osteen, Linjing Fang, Chongyuan Luo, Jacinta D Lucero, Rosa Gomez-Castanon, Joseph R Nery, Isai Silva-Garcia, Yan Pang, Terrence J Sejnowski, Susan B Powell, Joseph R Ecker, Eran A Mukamel, M Margarita Behrens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f76fdbda021efffa32a870cec8df1f9
https://doi.org/10.7554/elife.66909.sa2
https://doi.org/10.7554/elife.66909.sa2