Zobrazeno 1 - 10
of 261
pro vyhledávání: '"M Madan Babu"'
Autor:
Maria Polychronidou, Jingyi Hou, M Madan Babu, Prisca Liberali, Ido Amit, Bart Deplancke, Galit Lahav, Shalev Itzkovitz, Matthias Mann, Julio Saez‐Rodriguez, Fabian Theis, Roland Eils
Publikováno v:
Molecular Systems Biology, Vol 19, Iss 7, Pp n/a-n/a (2023)
Externí odkaz:
https://doaj.org/article/7ddb6c78b1e24454801a548f8ec9f20e
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 3, p e1008708 (2021)
Alternative splicing can expand the diversity of proteomes. Homologous mutually exclusive exons (MXEs) originate from the same ancestral exon and result in polypeptides with similar structural properties but altered sequence. Why would some genes swi
Externí odkaz:
https://doaj.org/article/77cc1c2c231a4d8f8caa9f0cd1a389b1
Autor:
Eric M Jones, Nathan B Lubock, AJ Venkatakrishnan, Jeffrey Wang, Alex M Tseng, Joseph M Paggi, Naomi R Latorraca, Daniel Cancilla, Megan Satyadi, Jessica E Davis, M Madan Babu, Ron O Dror, Sriram Kosuri
Publikováno v:
eLife, Vol 9 (2020)
The >800 human G protein–coupled receptors (GPCRs) are responsible for transducing diverse chemical stimuli to alter cell state- and are the largest class of drug targets. Their myriad structural conformations and various modes of signaling make it
Externí odkaz:
https://doaj.org/article/eef860197db949eb8e173ad8316b333e
Autor:
Thomas Lemberger, M Madan Babu
Publikováno v:
Molecular Systems Biology, Vol 15, Iss 12, Pp n/a-n/a (2019)
Molecular Systems Biology warmly welcomes its new academic Chief Editor, M. Madan Babu. Madan shared his thoughts on the evolution of the field and the importance of bridging disciplines to enable next generation systems biology.
Externí odkaz:
https://doaj.org/article/7fc816c2013a428eb9e72d0e67dc606a
Autor:
Qingtong Zhou, Dehua Yang, Meng Wu, Yu Guo, Wanjing Guo, Li Zhong, Xiaoqing Cai, Antao Dai, Wonjo Jang, Eugene I Shakhnovich, Zhi-Jie Liu, Raymond C Stevens, Nevin A Lambert, M Madan Babu, Ming-Wei Wang, Suwen Zhao
Publikováno v:
eLife, Vol 8 (2019)
Class A G-protein-coupled receptors (GPCRs) influence virtually every aspect of human physiology. Understanding receptor activation mechanism is critical for discovering novel therapeutics since about one-third of all marketed drugs target members of
Externí odkaz:
https://doaj.org/article/1fd7d071b55047e5a53a68b7fcb67b21
Autor:
Natalia Sanchez de Groot, Marc Torrent Burgas, Charles NJ Ravarani, Ala Trusina, Salvador Ventura, M Madan Babu
Publikováno v:
Molecular Systems Biology, Vol 15, Iss 4, Pp n/a-n/a (2019)
Abstract Phase separation of soluble proteins into insoluble deposits is associated with numerous diseases. However, protein deposits can also function as membrane‐less compartments for many cellular processes. What are the fitness costs and benefi
Externí odkaz:
https://doaj.org/article/d4c0cd8793f240388d4a61302f5060a5
Autor:
Rahul Mittal, Sunil K Sukumaran, Suresh K Selvaraj, David G Wooster, M Madan Babu, Alan D Schreiber, J Sjef Verbeek, Nemani V Prasadarao
Publikováno v:
PLoS Pathogens, Vol 6, Iss 11, p e1001203 (2010)
Neonatal meningitis due to Escherichia coli K1 is a serious illness with unchanged morbidity and mortality rates for the last few decades. The lack of a comprehensive understanding of the mechanisms involved in the development of meningitis contribut
Externí odkaz:
https://doaj.org/article/e196bdb56523407e8dc889611e7080f9
Autor:
Katherine P Weber, Subhajyoti De, Iwanka Kozarewa, Daniel J Turner, M Madan Babu, Mario de Bono
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e13922 (2010)
Defining the mutational landscape when individuals of a species grow separately and diverge over many generations can provide insights into trait evolution. A specific example of this involves studying changes associated with domestication where diff
Externí odkaz:
https://doaj.org/article/c1821fe56c22420bad06444516249420
Autor:
Laura Kapitzky, Pedro Beltrao, Theresa J Berens, Nadine Gassner, Chunshui Zhou, Arthur Wüster, Julie Wu, M Madan Babu, Stephen J Elledge, David Toczyski, R Scott Lokey, Nevan J Krogan
Publikováno v:
Molecular Systems Biology, Vol 6, Iss 1, Pp n/a-n/a (2010)
We present a cross‐species chemogenomic screening platform using libraries of haploid deletion mutants from two yeast species, Saccharomyces cerevisiae and Schizosaccharomyces pombe. We screened a set of compounds of known and unknown mode of actio
Externí odkaz:
https://doaj.org/article/2f5a0ad2ef864d9bbc46df89f6b00810
Publikováno v:
PLoS Genetics, Vol 5, Iss 9, p e1000645 (2009)
Organisms like Dictyostelium discoideum, often referred to as DNA damage "extremophiles", can survive exposure to extremely high doses of radiation and DNA crosslinking agents. These agents form highly toxic DNA crosslinks that cause extensive DNA da
Externí odkaz:
https://doaj.org/article/14be99851ca94e03a5567e9882faed56