A novel clofarabine bridge strategy facilitates allogeneic transplantation in patients with relapsed/refractory leukemia and high-risk myelodysplastic syndromes

Autor: K. Van Besien, Dorothy A. Sipkins, Lucy A. Godley, Olatoyosi Odenike, Andrew S. Artz, M M Le Beau, Michael J. Thirman, Hongtao Liu, Rajiv Agarwal, Sandeep Gurbuxani, Frederick L. Locke, Richard A. Larson, Rangesh Kunnavakkam, C White, Wendy Stock

Publikováno v: Bone Marrow Transplantation. 48:1437-1443

Patients with relapsed/refractory leukemias or advanced myelodysplastic syndrome (MDS) fare poorly following allogeneic hematopoietic cell transplant (HCT). We report prospective phase II study results of 29 patients given clofarabine 30 mg/m2/day i.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::811993501a3e2f38ba97da5db9120adc
https://doi.org/10.1038/bmt.2013.79

Sustained Expression of Hepatocyte Nuclear Factor-6 Leads to Loss of Pancreatic Beta-cells by Apoptosis

Autor: M M Le Beau, W. Pugh, J. Shen, Graeme I. Bell, Manami Hara, Kenneth S. Polonsky

Publikováno v: Experimental and Clinical Endocrinology & Diabetes. 115:654-661

Hepatocyte nuclear factor-6 (HNF-6) is the ONECUT-homeodomain transcription factor that is enriched in liver and also present in pancreas and central nervous system. It is expressed in the pancreatic bud at E10.5. In adult pancreas, its expression is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cfc0ceed0d54dd1de16344adc7de75e
https://doi.org/10.1055/s-2007-982514

Validation of WHO classification-based Prognostic Scoring System (WPSS) for myelodysplastic syndromes and comparison with the revised International Prognostic Scoring System (IPSS-R). A study of the International Working Group for Prognosis in Myelodysplasia (IWG-PM)

Autor: Alessandro Levis, Jaroslav Cermak, Hagop M. Kantarjian, Guillermo Sanz, G. Garcia-Manero, Ulrich Germing, Peter Valent, Otto Krieger, François Dreyfus, Marilyn L. Slovak, Luca Malcovati, Yasushi Miyazaki, Julie Schanz, Silvia Maria Meira Magalhães, Mikkael A. Sekeres, Jaroslaw P. Maciejewski, Reinhard Stauder, A.A. van de Loosdrecht, Detlef Haase, David T. Bowen, Pierre Fenaux, Mario Cazzola, Peter L. Greenberg, Heinz Tuechler, M M Le Beau, Teresa Vallespi, Wolfgang R. Sperr, Andrea Kuendgen, F. Solé, John M. Bennett, M.G. Della Porta, Christa Fonatsch, Michael Pfeilstöcker, Sudhir Tauro, Michael Luebbert

Publikováno v: Leukemia
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Leukemia, 29(7), 1502-1513. Nature Publishing Group
la Porta, M G, Tuechler, H, Malcovati, L, Schanz, J, Sanz, G, Garcia-Manero, G, Sole, F, Bennett, J M, Bowen, D, Fenaux, P, Dreyfus, F, Kantarjian, H, Kuendgen, A, Levis, A, Cermak, J, Fonatsch, C, Le Beau, M M, Slovak, M L, Krieger, O, Luebbert, M, Maciejewski, J, Magalhaes, S M M, Miyazaki, Y, Pfeilstocker, M, Sekeres, M A, Sperr, W R, Stauder, R, Tauro, S, Valent, P, Vallespi, T, van de Loosdrecht, A A, Germing, U, Haase, D, Greenberg, P L & Cazzola, M 2015, ' Validation of WHO classification-based Prognostic Scoring System (WPSS) for myelodysplastic syndromes and comparison with the revised International Prognostic Scoring System (IPSS-R). A study of the International Working Group for Prognosis in Myelodysplasia (IWG-PM) ', Leukemia, vol. 29, no. 7, pp. 1502-1513 . https://doi.org/10.1038/leu.2015.55

A risk-adapted treatment strategy is mandatory for myelodysplastic syndromes (MDS). We refined the World Health Organization (WHO)-classification-based Prognostic Scoring System (WPSS) by determining the impact of the newer clinical and cytogenetic f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d75a03d10b91627850102adeb8a567c6
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=1306

Identification and molecular characterization of CALM/AF10fusion products in T cell acute lymphoblastic leukemia and acute myeloid leukemia

Autor: Jose A. Martinez-Climent, Stefan K. Bohlander, M M Le Beau, Janet D. Rowley, Katrin M. Carlson, Christine Vignon

Publikováno v: Leukemia. 14:100-104

The t(10;11)(p12-p13;q14-q21) observed in a subset of patients with either acute lymphoblastic leukemia or acute myeloid leukemia has been shown to result in the fusion of AF10 on chromosome 10 with CALM (also named CLTH) on chromosome 11. AF10 was o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded70a14a63ef2425c2fb71feb3b5690
https://doi.org/10.1038/sj.leu.2401629

Human KRML (MAFB): cDNA Cloning, Genomic Structure, and Evaluation as a Candidate Tumor Suppressor Gene in Myeloid Leukemias

Autor: Pauline W. Wang, Markus Stoffel, Gregory S. Barsh, S P Cordes, James D. Eisenbart, M M Le Beau

Publikováno v: Genomics. 59:275-281

Members of the MAF family of basic region/leucine zipper transcription factors can affect transcription in either a positive or a negative fashion, depending on their partner protein(s) and the context of the target promoter. The KRML (MAFB) transcri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::453c7c24a85c1934f55ed8b4424c5768
https://doi.org/10.1006/geno.1999.5884