Zobrazeno 1 - 3
of 3
pro vyhledávání: '"M M Hubinette"'
Publikováno v:
Gene Therapy. 6:922-930
Herpes simplex virus (HSV) is a new platform for gene therapy. We cloned the human herpesvirus HSV-1 strain F genome into a bacterial artificial chromosome (BAC) and adapted chromosomal gene replacement technology to manipulate the viral genome. This
Publikováno v:
Methods in enzymology. 306
Autor:
K Schubert, Joe Sasadeusz, S. Safrin, Peter K. Cheung, Stephen L. Sacks, Frank Tufaro, M M Hubinette
Publikováno v:
Journal of virology. 71(5)
In the majority of cases, the mechanism underlying the resistance to acyclovir (ACV) of herpes simplex viruses (HSVs) is thymidine kinase (TK) deficiency. Plaque isolates from eight ACV-resistant (ACVr) clinical isolates from AIDS patients, of which