Zobrazeno 1 - 10
of 66
pro vyhledávání: '"M M, Reidenberg"'
Publikováno v:
British Journal of Cancer
The antiproliferative effects of gossypol on human MCF-7 mammary cancer cells and cyclin D1-transfected HT-1060 human fibrosarcoma cells were investigated by cell cycle analysis and effects on the cell cycle regulatory proteins Rb and cyclin D1. Flow
Autor:
E M, Coutinho, C, Athayde, G, Atta, Z P, Gu, Z W, Chen, G W, Sang, E, Emuveyan, A O, Adekunle, J, Mati, J, Otubu, M M, Reidenberg, S J, Segal
Publikováno v:
Contraception. 61(1)
The safety and efficacy of gossypol continues to be controversial. The aim of this study was to evaluate gossypol as a contraceptive pill for men at doses lower than those previously prescribed and in men from various ethnic origin. A total of 151 me
Autor:
M. M. Reidenberg
Publikováno v:
JAMA: The Journal of the American Medical Association. 265:3107-3109
Autor:
P, Bushunow, M M, Reidenberg, J, Wasenko, J, Winfield, B, Lorenzo, S, Lemke, B, Himpler, R, Corona, T, Coyle
Publikováno v:
Journal of neuro-oncology. 43(1)
Gossypol, a polyphenolic compound which depletes cellular energy by inhibition of several intracellular dehydrogenases, has been shown to have antiproliferative activity against human glial tumor cell lines in vitro and in nude mouse xenografts. Huma
Publikováno v:
Zhongguo yao li xue bao = Acta pharmacologica Sinica. 18(6)
To study the mechanism of gossypol-induced hypokalemia.The 11 beta-hydroxysteroid dehydrogenase (11 beta-OHSD) protein was prepared from guinea pig kidney. The activity of 11 beta-OHSD with NAD or NADP as the coenzyme was measured by HPLC in both con
Autor:
M M, Reidenberg
Publikováno v:
JAMA. 273(21)
The issue of what drug effects to measure, surrogate end points, has been emphasized by two recent clinical trials. Several recent studies have given us new information about why different people react so differently to the same dose of the same medi
Autor:
M M, Reidenberg
Publikováno v:
JAMA. 270(2)
Autor:
M R Flack, Nancy Mullen, R G Pyle, Bruce C. Nisula, R A Knazek, M M Reidenberg, Y W Wu, B Lorenzo
Publikováno v:
The Journal of clinical endocrinology and metabolism. 76(4)
Medical treatment of metastatic adrenal cancer is largely unsuccessful and has considerable toxicity. We previously demonstrated the activity of the plant toxin gossypol against human adrenal cancers in nude mice. We therefore examined the efficacy a
Autor:
M M, Reidenberg
Publikováno v:
Clinical pharmacokinetics. 24(1)
Autor:
M M, Reidenberg, Z P, Gu, B, Lorenzo, E, Coutinho, C, Athayde, J, Frick, F, Alvarez, V, Brache, E E, Emuveyan
Publikováno v:
Clinical chemistry. 39(1)
Hypokalemia has been associated with the taking of gossypol, a potential oral antifertility drug for men. Because the frequency of this response differed in different parts of the world, this study was done to learn if "normal" serum [K+] also differ