Zobrazeno 1 - 10
of 194
pro vyhledávání: '"M M, McLaughlin"'
Publikováno v:
Journal of Biological Chemistry. 269:32027-32030
The yeast TOR1 and TOR2 proteins were previously discovered as putative targets of the immunosuppressive drug rapamycin. Although their cellular function is unknown, they are predicted to be at least 215 kDa in size and possess a C-terminal phosphati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d4244701610dc623c09fe6e84c62e55
https://doi.org/10.1016/s0021-9258(18)31592-8
https://doi.org/10.1016/s0021-9258(18)31592-8
Publikováno v:
Microbiology. 140:1533-1542
We have cloned a Candida albicans gene, which encodes a cyclic nucleotide phosphodiesterase (PDEase), by complementation in a Saccharomyces cerevisiae PDEase-deficient mutant. The deduced amino acid sequence is similar to that of the low-affinity PDE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a1bc6a4426db2ce024961ab0b481c4
https://doi.org/10.1099/13500872-140-7-1533
https://doi.org/10.1099/13500872-140-7-1533
Publikováno v:
Journal of Clinical Microbiology. 33:3257-3259
Isolation rates of Haemophilus ducreyi from cases of chancroid are low. Experts recommend that isolation media be incubated at 33 to 35 degrees C, but the possible effect of this temperature range on the recovery of H. ducreyi has not been evaluated.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e6a9153c239743bc94372c8b8764903
https://doi.org/10.1128/jcm.33.12.3257-3259.1995
https://doi.org/10.1128/jcm.33.12.3257-3259.1995
Autor:
A, Truneh, S, Sharma, C, Silverman, S, Khandekar, M P, Reddy, K C, Deen, M M, McLaughlin, S M, Srinivasula, G P, Livi, L A, Marshall, E S, Alnemri, W V, Williams, M L, Doyle
Publikováno v:
The Journal of biological chemistry. 275(30)
TRAIL is a member of the tumor necrosis factor (TNF) family of cytokines which induces apoptotic cell death in a variety of tumor cell lines. It mediates its apoptotic effects through one of two receptors, DR4 and DR5, which are members of of the TNF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::42d086cba05e17b696f1f0a553e7c4c8
https://pubmed.ncbi.nlm.nih.gov/10770955
https://pubmed.ncbi.nlm.nih.gov/10770955
Publikováno v:
Molecular pharmacology. 50(4)
To identify functional domains of the 886-amino acid human recombinant cAMP-specific phosphodiesterase (PDE) subtype A (rhPDE4A), we engineered the expression of seven mutant proteins containing both NH2- and COOH-terminal truncations. The level of r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::149cd20f3f29140a1a52671d1707cbb1
https://pubmed.ncbi.nlm.nih.gov/8863835
https://pubmed.ncbi.nlm.nih.gov/8863835
Publikováno v:
Blood. 88(4)
Cyclic adenosine monophosphate (cAMP) is an important modulator of platelet responses to agonists. Cyclic nucleotide phosphodiesterase (PDE) controls intracellular cAMP concentrations by hydrolyzing it to AMP. The major PDE activity in platelets is P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7a86cbca1e226f529efdfeffef65a275
https://pubmed.ncbi.nlm.nih.gov/8695850
https://pubmed.ncbi.nlm.nih.gov/8695850
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 276(2)
Human peripheral blood monocytes were treated for 4 h with a combination of the beta-agonist salbutamol (3 microM) and the low-Km cAMP-specific phosphodiesterase (PDE4) inhibitor rolipram (30 microM) to produce a prolonged elevation of cAMP and conse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::de8734de83ac6a0fe2b99eeb477d0509
https://pubmed.ncbi.nlm.nih.gov/8632354
https://pubmed.ncbi.nlm.nih.gov/8632354
Autor:
S H, Cheeseman, D, Havlir, M M, McLaughlin, T C, Greenough, J L, Sullivan, D, Hall, S E, Hattox, S A, Spector, D S, Stein, M, Myers
Publikováno v:
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association. 8(2)
In these Phase I/II open-label clinical trials, 62 persons with human immunodeficiency virus type 1 (HIV-1) infection and CD4+ cell counts400/mm3 received nevirapine at doses of 12.5, 50, and 200 mg/day, alone or in combination with zidovudine, 200 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9d3d7291e424ca56bb3aa7de55d67de3
https://pubmed.ncbi.nlm.nih.gov/7530585
https://pubmed.ncbi.nlm.nih.gov/7530585
Publikováno v:
The Journal of biological chemistry. 269(51)
The yeast TOR1 and TOR2 proteins were previously discovered as putative targets of the immunosuppressive drug rapamycin. Although their cellular function is unknown, they are predicted to be at least 215 kDa in size and possess a C-terminal phosphati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::76e3ef9827e9628b315d6882b7c223f8
https://pubmed.ncbi.nlm.nih.gov/7528205
https://pubmed.ncbi.nlm.nih.gov/7528205
Publikováno v:
The Journal of biological chemistry. 268(9)
We have isolated cDNA clones from human frontal cortex cDNA libraries that encode a unique subtype of the low-Km, cAMP-specific phosphodiesterases (PDEs IV). The 564-amino acid sequence of the protein (human brain PDE IV (hPDE IVB)) shows significant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1ac9c9b58f4d4501dea7afaaef428b5a
https://pubmed.ncbi.nlm.nih.gov/8384210
https://pubmed.ncbi.nlm.nih.gov/8384210