Highly Potent and Intestine Specific P-Glycoprotein Inhibitor to Enable Oral Delivery of Taxol.

Autor: Zhou X; College of Pharmaceutical Sciences, State Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China., Zhang P; Center of Drug Discovery, State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, China Pharmaceutical University, 24 Tongjiaxiang Road, Nanjing, 210009, China., Yang Y; College of Pharmaceutical Sciences, State Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China., Shi W; Center of Drug Discovery, State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, China Pharmaceutical University, 24 Tongjiaxiang Road, Nanjing, 210009, China., Liu L; College of Pharmaceutical Sciences, State Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China., Lai Z; College of Pharmaceutical Sciences, State Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China., Zhang X; College of Pharmaceutical Sciences, State Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China., Pan P; College of Pharmaceutical Sciences, State Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China., Li L; Department of Gastroenterology, T, he First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China., Du J; Department of Gastroenterology, T, he First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China., Qian H; Center of Drug Discovery, State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, China Pharmaceutical University, 24 Tongjiaxiang Road, Nanjing, 210009, China., Cui S; College of Pharmaceutical Sciences, State Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 Nov 04; Vol. 63 (45), pp. e202412649. Date of Electronic Publication: 2024 Sep 17.

Life-threatening hypokalaemia and lactate accumulation after autointoxication with Stacker 2, a 'powerful slimming agent'

Autor: M M Malingré, B C P Koch, A K M Bartelink, L R H de Wijkerslooth, Paul Smits

Publikováno v: British Journal of Clinical Pharmacology, 66, 5, pp. 728-31
British Journal of Clinical Pharmacology, 66, 728-31

In recent years the use of so-called fatburners such as Stacker® has gained widespread popularity in the USA. These dietary supplements contain substances such as Ephedra and caffeine.The drugs are supposed to stimulate athletic performance and redu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35e2c3c24809936722345430f9fd2631
https://doi.org/10.1111/j.1365-2125.2008.03279.x

Coadministration of oral cyclosporin A enables oral therapy with paclitaxel

Autor: J M, Meerum Terwogt, M M, Malingré, J H, Beijnen, W W, ten Bokkel Huinink, H, Rosing, F J, Koopman, O, van Tellingen, M, Swart, J H, Schellens

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 5(11)

i.v. paclitaxel is inconvenient and associated with significant and poorly predictable side effects largely due to the pharmaceutical vehicle Cremophor EL. Oral administration may be attractive because it may circumvent the use of Cremophor EL. Howev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b9891d35e4bd0bb594a0ae0108b86cf7
https://pubmed.ncbi.nlm.nih.gov/10589748

Interaction of flucloxacillin and quinidine.

Autor: Comuth, W., Comuth, J., Hauer, R., Malingré, M.

Publikováno v: European Journal of Clinical Pharmacology; May2012, Vol. 68 Issue 5, p891-893, 3p, 1 Graph

Colloids in Drug Delivery

Autor: Monzer Fanun

Colloidal drug delivery systems present a range of therapeutic benefits in the treatment of a number of challenging conditions, allowing researchers to cross barriers that have previously prevented efficient treatment while offering improved and more