Zobrazeno 1 - 10 of 23 pro vyhledávání: '"M M, Horng"'
1
Tipranavir (PNU-140690): A Potent, Orally Bioavailable Nonpeptidic HIV Protease Inhibitor of the 5,6-Dihydro-4-hydroxy-2-pyrone Sulfonamide Class
Autor: Lester A. Dolak, Johnson Paul D, Chong Kt, Harvey Irving Skulnick, Paul K. Tomich, Michael John Bohanon, Strohbach Joseph Walter, Suvit Thaisrivongs, Steve Turner, K. D. Watenpaugh, M.‐M. Horng, M.N. Janakiraman, R. R. Hinshaw, Paul A. Aristoff, J. C. Lynn, Eric P. Seest, Tommasi Ruben A
Publikováno v: Journal of Medicinal Chemistry. 41:3467-3476
A broad screening program previously identified phenprocoumon (1) as a small molecule template for inhibition of HIV protease. Subsequent modification of this lead through iterative cycles of structure-based design led to the activity enhancements of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb61de09a28125894737f3e08843301
https://doi.org/10.1021/jm9802158
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2
Structure-Based Design of HIV Protease Inhibitors: 5,6-Dihydro-4-hydroxy-2-pyrones as Effective, Nonpeptidic Inhibitors
Autor: J. C. Lynn, Tommasi Ruben A, Johnson Paul D, Strohbach Joseph Walter, R. R. Hinshaw, M.N. Janakiraman, Chong Kt, Turner, Paul A. Aristoff, Morge Rr, Howe Wj, Tomich Pk, Donna L. Romero, M.‐M. Horng, Barry C. Finzel, Carolyn Biles, K. D. Watenpaugh, Suvit Thaisrivongs
Publikováno v: Journal of Medicinal Chemistry. 39:4630-4642
From a broad screening program, the 4-hydroxycoumarin phenprocoumon (I) was previously identified as a lead template with HIV protease inhibitory activity. The crystal structure of phenprocoumon/HIV protease complex initiated a structure-based design
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb2825cd7d8c44b64d6d1c8790f32737
https://doi.org/10.1021/jm960228q
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3
Structure-Based Design of Novel HIV Protease Inhibitors: Sulfonamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Non-Peptidic Inhibitors
Autor: S, Thaisrivongs, M N, Janakiraman, K T, Chong, P K, Tomich, L A, Dolak, S R, Turner, J W, Strohbach, J C, Lynn, M M, Horng, R R, Hinshaw, K D, Watenpaugh
Publikováno v: Journal of Medicinal Chemistry. 39:2400-2410
The low oral bioavailability and rapid biliary excretion of peptide-derived HIV protease inhibitors have limited their utility as potential therapeutic agents. Our broad screening program to discover non-peptidic HIV protease inhibitors previously id
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe175551c1e0beaead1087dbbcdb75b9
https://doi.org/10.1021/jm950888f
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4
Cycloalkylpyranones and Cycloalkyldihydropyrones as HIV Protease Inhibitors: Exploring the Impact of Ring Size on Structure−Activity Relationships
Autor: R. R. Hinshaw, M.‐M. Horng, W. Jeffrey Howe, David J. Anderson, and Steve R. Turner, Chong Kt, Steve A. Mizsak, Jeanette Kay Morris, Paul K. Tomich, Strohbach Joseph Walter, Karen Rene Romines
Publikováno v: Journal of Medicinal Chemistry. 39:4125-4130
Previously, 3-substituted cycloalkylpyranones, such as 2d, have proven to be effective inhibitors of HIV protease. In an initial series of 3-(1-phenylpropyl) derivatives with various cycloalkyl ring sizes, the cyclooctyl analog was the most potent. W
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a199dab51c8bcffc1c4be5a96313db5
https://doi.org/10.1021/jm960296c
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8
Allosteric inhibition of Staphylococcus aureus D-alanine:D-alanine ligase revealed by crystallographic studies
Autor: Alice H. Lin, Keith R. Marotti, Shenping Liu, John T. Herberg, Jeanne S. Chang, Paul K. Tomich, M.‐M. Horng
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 103(41)
d -alanine: d -alanine ligase (DDl) is an essential enzyme in bacterial cell wall biosynthesis and an important target for developing new antibiotics. It catalyzes the formation of d -alanine: d -alanine dipeptide, sequentially by using one d -alanin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad7af334f0002cfff3ae43b1297b9b4b
https://pubmed.ncbi.nlm.nih.gov/17015835
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10
Structure-based design of nonpeptidic HIV protease inhibitors from a cyclooctylpyranone lead structure
Autor: Tomich Pk, Howe Wj, K D Lovasz, M.‐M. Horng, K. D. Watenpaugh, J. C. Lynn, Jeanette Kay Morris, Karen Rene Romines, Chong Kt, M.N. Janakiraman
Publikováno v: Journal of medicinal chemistry. 38(22)
Recently, the novel cyclooctylpyranone HIV protease inhibitor 1 was identified in our labs, and an X-ray structure of this inhibitor complexed with HIV-2 protease was obtained. This crystal structure was used to develop two strategies for creating de
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a7edbf2fae1fd29b53c403e81525e8a
https://pubmed.ncbi.nlm.nih.gov/7473573
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