Zobrazeno 1 - 10
of 29
pro vyhledávání: '"M M, Hamawy"'
Publikováno v:
The Journal of Immunology. 153:4655-4662
Tyrosine phosphorylation of proteins is an essential component of high affinity IgE receptor (Fc epsilon RI) signaling and secretion. This signaling and secretion is also dependent on the organization of the cytoskeleton. Here we report that the aggr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bde5e6e30331290635bf6b7f689f723
https://doi.org/10.4049/jimmunol.153.10.4655
https://doi.org/10.4049/jimmunol.153.10.4655
Publikováno v:
The Journal of Immunology. 149:615-621
Rat basophilic leukemia (RBL-2H3) cells are a useful in vitro model for studies of mast cells and basophils. We examined the adherence of RBL-2H3 cells to different extracellular matrix proteins and the effect of such attachment on secretion. The cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b2a84058104cb9c87fbcee481bf4dfb
https://doi.org/10.4049/jimmunol.149.2.615
https://doi.org/10.4049/jimmunol.149.2.615
Publikováno v:
The Journal of Immunology. 148:524-531
A mAb was isolated (mAb BD6) that recognized a surface glycoprotein on rat basophilic leukemia cells (RBL-2H3). The antibody bound to 2 x 10(6) molecules/cell and specifically blocked IgE binding (50% inhibition with 3.48 +/- 0.51 micrograms/ml; mean
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed81ff28d0cab43a5fa8b2f34634dce6
https://doi.org/10.4049/jimmunol.148.2.524
https://doi.org/10.4049/jimmunol.148.2.524
Publikováno v:
Immunological reviews. 183
Studies in non-human primates to evaluate tolerance strategies in organ transplantation have led to innovation in human transplantation. The two strategies we have studied in detail in non-human primates are T-cell depletion by anti-CD3 immunotoxin a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b5e0442393768c0da31d2fa947b28f2c
https://pubmed.ncbi.nlm.nih.gov/11782258
https://pubmed.ncbi.nlm.nih.gov/11782258
Autor:
C S, Cho, L C, Burkly, J H, Fechner, A D, Kirk, T D, Oberley, Y, Dong, K G, Brunner, D, Peters, C N, Tenhoor, K, Nadeau, G, Yagci, N, Ishido, J M, Schultz, M, Tsuchida, M M, Hamawy, S J, Knechtle
Publikováno v:
Transplantation. 72(4)
Several conventional forms of immunosuppression have been shown to antagonize the efficacy of anti-CD154 monoclonal antibody- (mAb) based costimulatory molecule blockade immunotherapy. Our objective was to determine if allograft recipients treated wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6063f6903b0ced4b8ca1fd38c9e2eb7b
https://pubmed.ncbi.nlm.nih.gov/11544416
https://pubmed.ncbi.nlm.nih.gov/11544416
Autor:
J H, Fechner, Y, Dong, X, Hong, K G, Brunner, M, Tsuchida, D, Neville, J, Scharff, F, Lee, T D, Oberley, D, Peters, J M, Schultz, E R, Manthei, M M, Hamawy, S J, Knechtle
Publikováno v:
Transplantation. 72(4)
Anti-CD3 immunotoxin (IT), a T-cell-depleting agent, prolongs survival of renal allografts in a rhesus monkey model without the need for long-term immunosuppression. In this study we sought to further prolong allograft survival by giving short-term c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c1e9428e939cbd4e55bd49d182d4d610
https://pubmed.ncbi.nlm.nih.gov/11544415
https://pubmed.ncbi.nlm.nih.gov/11544415
Publikováno v:
Transplantation. 72(3)
The T-cell receptor (TCR)/CD3 complex is the target of therapeutic strategies aimed at prolonging allograft survival. The immunotoxin FN18-CRM9, composed of the anti-CD3 monoclonal antibody FN18 and the mutated diphtheria toxin CRM9, is useful for pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f3c612e2cfd9186336e05fc03763f3f2
https://pubmed.ncbi.nlm.nih.gov/11502982
https://pubmed.ncbi.nlm.nih.gov/11502982
Autor:
A S, Lagoo, P J, Buckley, L J, Burchell, D, Peters, J H, Fechner, M, Tsuchida, Y, Dong, X, Hong, K G, Brunner, T D, Oberley, M M, Hamawy, S J, Knechtle
Publikováno v:
Transplantation. 70(6)
In our previously described primate renal allograft model, T cell ablation leads to long-term graft survival. The role of endothelial cell alteration in chronic rejection was examined in our model.Renal transplants were performed in rhesus monkeys us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b37c04fda07c5d9fc5e22fe36043f5ac
https://pubmed.ncbi.nlm.nih.gov/11014641
https://pubmed.ncbi.nlm.nih.gov/11014641
Publikováno v:
Blood. 95(9)
The activation of blood cells, including T cells, triggers intracellular signals that control the expression of critical molecules, including cytokines and cytokine receptors. We show that T-cell receptor (TCR) ligation increases the cellular level o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4c8d20b5003231e1f457119e1f8c4383
https://pubmed.ncbi.nlm.nih.gov/10779414
https://pubmed.ncbi.nlm.nih.gov/10779414
Publikováno v:
The Journal of biological chemistry. 275(2)
The T cell receptor (TCR)-CD3 complex and the costimulatory molecule CD28 are critical for T cell function. Both receptors utilize protein tyrosine kinases (PTKs) for the phosphorylation of various signaling molecules, a process that is critical for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7dafa9f5e9f27aab43b1019e31bdde75
https://pubmed.ncbi.nlm.nih.gov/10625683
https://pubmed.ncbi.nlm.nih.gov/10625683