Výsledky vyhledávání - "M M, Griffiths"

Oral administration of an immunodominant human collagen peptide modulates collagen-induced arthritis

Autor: S D Khare, C J Krco, M M Griffiths, H S Luthra, C S David

Publikováno v: The Journal of Immunology. 155:3653-3659

Human type II collagen (HuCII) may be one of the autoantigens involved in human rheumatoid arthritis (RA). By using over-lapping peptides, we have previously described an immunodominant region (HuCII.250-270) on HuCII. In the present study, this 21-m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::825673f26fdeb94895dcb47f1513e19f
https://doi.org/10.4049/jimmunol.155.7.3653

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Collagen-induced arthritis and TCRs in SWR and B10.Q mice expressing an Ek alpha transgene

Autor: M M Griffiths, G H Nabozny, J Hanson, D S Harper, S McCall, K G Moder, G W Cannon, H S Luthra, C S David

Publikováno v: The Journal of Immunology. 153:2758-2768

B10.Ek alpha transgenic mice were mated with H2-E B10.Q and SWR mice. F1 and F1 x parental strain backcross progeny were tested for arthritis and autoimmune reactivity to mouse type II collagen (MII) after immunization with bovine, chick, deer, or hu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d9f99c5b233353b10c5a5e5d9b63539f
https://doi.org/10.4049/jimmunol.153.6.2758

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Collagen-induced arthritis in rats. Examination of the epitope specificities of circulating and cartilage-bound antibodies produced by outbred and inbred rats using cyanogen bromide-derived peptides purified from heterologous and homologous type II collagens

Autor: M A Cremer, K Terato, W C Watson, M M Griffiths, A S Townes, A H Kang

Publikováno v: The Journal of Immunology. 149:1045-1053

To determine the number and location of antibody binding epitopes on type II collagen, outbred and inbred rats were immunized with chick, bovine, human, and rat type II collagen (CII, BII, HII, and RII); all sera were assayed for reaction with a pane

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f12b397890f92640254bf7a452c899fd
https://doi.org/10.4049/jimmunol.149.3.1045

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Immunogenetics of collagen-induced arthritis in rats. Both MHC and non-MHC gene products determine the epitope specificity of immune response to bovine and chick type II collagens

Autor: M M Griffiths, M A Cremer, D S Harper, S McCall, G W Cannon

Publikováno v: The Journal of Immunology. 149:309-316

Seven inbred, RT1-congenic rat strains were immunized with native bovine (BII), porcine (PII), or chick (CII) type II collagen and observed for onset, incidence, and severity of arthritis. Clinical results were compared with IgG reactive with native

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a542aeef1f4aa9780797ba875afb8010
https://doi.org/10.4049/jimmunol.149.1.309

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Genetic analysis of collagen-induced arthritis in rats: a polygenic model for rheumatoid arthritis predicts a common framework of cross-species inflammatory/autoimmune disease loci

Autor: M M, Griffiths, E F, Remmers

Publikováno v: Immunological reviews. 184

Collagen-induced arthritis (CIA) is a useful model for dissecting the genetic patterns underlying susceptibility to rheumatoid arthritis (RA) and related chronic/inflammatory autoimmune diseases. CIA exhibits three phenotypes characteristic of autoim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c06b917c063e472894f8ce0563f018fb
https://pubmed.ncbi.nlm.nih.gov/12086311

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Genetic factors regulating experimental arthritis in mice and rats

Autor: R L, Wilder, E F, Remmers, Y, Kawahito, P S, Gulko, G W, Cannon, M M, Griffiths

Publikováno v: Current directions in autoimmunity. 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::62f07ec8e0b6a71aa93580fc1007cca6
https://pubmed.ncbi.nlm.nih.gov/11791440

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Identification of four new quantitative trait loci regulating arthritis severity and one new quantitative trait locus regulating autoantibody production in rats with collagen-induced arthritis

Autor: M M, Griffiths, J, Wang, B, Joe, S, Dracheva, Y, Kawahito, J S, Shepard, V R, Reese, S, McCall-Vining, A, Hashiramoto, G W, Cannon, E F, Remmers, R L, Wilder

Publikováno v: Arthritis and rheumatism. 43(6)

Collagen-induced arthritis (CIA) is a polygenic model of experimentally induced autoimmunity and chronic joint inflammation. This study maps genetic loci that regulate CIA susceptibility in DA/Bkl (DA) and BN/SsNHsd (BN) rats.Genome scans covering ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::325e6d0691264c1b70f80103c30cf7ff
https://pubmed.ncbi.nlm.nih.gov/10857786

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Adjuvant arthritis in rats: susceptibility to arthritis induced by Mycobacterium butyricum and Mycobacterium tuberculosis

Autor: Allen D. Sawitzke, Frederic Clayton, Grant W. Cannon, M. M. Griffiths, S Openshaw

Publikováno v: Transplantation proceedings. 31(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::346b1c8652aeed8c211913550c2b18c5
https://pubmed.ncbi.nlm.nih.gov/10331013

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Identification of a new non-major histocompatibility complex genetic locus on chromosome 2 that controls disease severity in collagen-induced arthritis in rats

Autor: P S, Gulko, Y, Kawahito, E F, Remmers, V R, Reese, J, Wang, S V, Dracheva, L, Ge, R E, Longman, J S, Shepard, G W, Cannon, A D, Sawitzke, R L, Wilder, M M, Griffiths

Publikováno v: Arthritis and rheumatism. 41(12)

To identify novel non-major histocompatibility complex (non-MHC) genetic loci controlling the severity of homologous rat type II collagen-induced arthritis (CIA).We conducted a genome-wide scan to identify CIA regulatory quantitative trait loci (QTL)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6cfeff3569b145af00ffc9ea0abef9ac
https://pubmed.ncbi.nlm.nih.gov/9870869

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HLA-DQ6/8 double transgenic mice develop auricular chondritis following type II collagen immunization: a model for human relapsing polychondritis

Autor: D S, Bradley, P, Das, M M, Griffiths, H S, Luthra, C S, David

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 161(9)

We have generated transgenic (tg) mice expressing HLA-DQ8alphabeta (DQA1*0301/DQB*0302) or HLA-DQ6alphabeta (DQA1*0103/DQB1*0601) molecules lacking endogenous murine class II expression (A beta0) to investigate the ability of these HLA class II to pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8554753a35e8dcedb478424a74ff5177
https://pubmed.ncbi.nlm.nih.gov/9794442

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