Zobrazeno 1 - 10
of 387
pro vyhledávání: '"M Loy"'
Autor:
Daniel J. Diaz, Chengyue Gong, Jeffrey Ouyang-Zhang, James M. Loy, Jordan Wells, David Yang, Andrew D. Ellington, Alexandros G. Dimakis, Adam R. Klivans
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Engineering stabilized proteins is a fundamental challenge in the development of industrial and pharmaceutical biotechnologies. We present Stability Oracle: a structure-based graph-transformer framework that achieves SOTA performance on accu
Externí odkaz:
https://doaj.org/article/09e8ba873c164e1eb910e28fd655392f
Autor:
Simon d’Oelsnitz, Daniel J. Diaz, Wantae Kim, Daniel J. Acosta, Tyler L. Dangerfield, Mason W. Schechter, Matthew B. Minus, James R. Howard, Hannah Do, James M. Loy, Hal S. Alper, Y. Jessie Zhang, Andrew D. Ellington
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract A major challenge to achieving industry-scale biomanufacturing of therapeutic alkaloids is the slow process of biocatalyst engineering. Amaryllidaceae alkaloids, such as the Alzheimer’s medication galantamine, are complex plant secondary m
Externí odkaz:
https://doaj.org/article/a590be639471443d8f68f7c532e9fc11
Autor:
Daniel J. Diaz, Chengyue Gong, Jeffrey Ouyang-Zhang, James M. Loy, Jordan Wells, David Yang, Andrew D. Ellington, Alex Dimakis, Adam R. Klivans
Stabilizing proteins is a fundamental challenge in protein engineering and is almost always a prerequisite for the development of industrial and pharmaceutical biotechnologies. Here we present Stability Oracle: a structure-based graph-transformer fra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e0c67e32a0c27baf221dc7362b72e04
https://doi.org/10.1101/2023.05.15.540857
https://doi.org/10.1101/2023.05.15.540857
Akademický článek
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Autor:
Robert L. Cook, Christa L. Cook, Manju Karki, Kathleen M. Weber, Kathleen A. Thoma, Chelsea M. Loy, Lakshmi Goparaju, Bridgett Rahim-Williams
Publikováno v:
BMC Public Health, Vol 16, Iss 1, Pp 1-8 (2016)
Abstract Background Women living with HIV have increased prevalence of medical and psychological comorbidities that could be adversely affected by alcohol consumption. Little is known about their unique motivations for drinking or perceptions of HIV-
Externí odkaz:
https://doaj.org/article/d69ca185674e46c29b680cf6cacf9b0e
Publikováno v:
J Biol Phys
One fundamental problem of protein biochemistry is to predict protein structure from amino acid sequence. The inverse problem, predicting either entire sequences or individual mutations that are consistent with a given protein structure, has received
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ea7bd1d3f5b81e12aec7b9a171f961
https://doi.org/10.1007/s10867-021-09593-6
https://doi.org/10.1007/s10867-021-09593-6
Autor:
F. Lunardi, V. Verzeletti, F. Pezzuto, C. De Chellis, V. Tauro, F. Fortarezza, A. Kilitci, M. Schiavon, E. Faccioli, M. Loy, F. Rea, F. Calabrese
Publikováno v:
The Journal of Heart and Lung Transplantation. 42:S72
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45df9d2919a3225d5b95e4d9e2d504df
https://doi.org/10.1016/j.healun.2023.02.156
https://doi.org/10.1016/j.healun.2023.02.156
Autor:
Uli Kazmaier, Ines Truebenbach, Dominik M. Loy, Miriam Höhn, Sarah Kern, Ernst Wagner, Jan Gorges
Publikováno v:
Molecular Pharmaceutics. 16:2405-2417
In the current study, nanoparticles containing the antimetabolite drug methotrexate (MTX) and the novel tubulin-binding drug pretubulysin (PT) were developed for combination chemotherapy. Polyelectrolyte complexes were formed based on ∼20 nm cation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9548b9f5df1b01b3b3db645341b97963
https://doi.org/10.1021/acs.molpharmaceut.9b00038
https://doi.org/10.1021/acs.molpharmaceut.9b00038
Publikováno v:
Processes, Vol 9, Iss 129, p 129 (2021)
Processes
Volume 9
Issue 1
Processes
Volume 9
Issue 1
Active pharmaceutical ingredients (API) with suboptimal pharmacokinetic properties may require formulation into nanoparticles. In addition to the quality of the excipients, production parameters are crucial for producing nanoparticles which reliably
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5865f49540b4513602a4c63c851a5ed7
https://www.mdpi.com/2227-9717/9/1/129
https://www.mdpi.com/2227-9717/9/1/129
Background and objectives: Next generation sequencing (NGS) has promising applications in transfusion medicine. Exome sequencing (ES) is increasingly used in the clinical setting, and blood group interpretation is an additional value that could be ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2127::da1e60ac0d7d4a67c4fe5d277a55980d
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3119861
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3119861