Zobrazeno 1 - 8
of 8
pro vyhledávání: '"M Lizeth Orozco Morales"'
Autor:
Elly Marcq, Anna K Nowak, W Joost Lesterhuis, Caitlin M Tilsed, Nicola Principe, Amber-Lee Phung, Kofi L P Stevens, Omar Elaskalani, Ben Wylie, Fezaan Sheikh, M Lizeth Orozco Morales, Joel Kidman, Scott A Fisher, Alison M McDonnell, Jonathan Chee
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 9 (2024)
Background Antibodies that target immune checkpoints such as cytotoxic T lymphocyte antigen 4 (CTLA-4), programmed cell death protein/ligand 1 (PD-1/PD-L1) are approved for treatment of multiple cancer types. Chemotherapy is often administered with i
Externí odkaz:
https://doaj.org/article/7f07a0c5e8004791ac4fe2312e89506b
Autor:
M Lizeth Orozco Morales, Catherine A Rinaldi, Emma de Jong, Sally M Lansley, Y C Gary Lee, Rachael M Zemek, Anthony Bosco, Richard A Lake, W Joost Lesterhuis
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0274364 (2023)
Mesothelioma is characterised by its aggressive invasive behaviour, affecting the surrounding tissues of the pleura or peritoneum. We compared an invasive pleural model with a non-invasive subcutaneous model of mesothelioma and performed transcriptom
Externí odkaz:
https://doaj.org/article/2d135eaea4984e23b135b7a3cb4c24d4
Autor:
M. Lizeth Orozco Morales, Catherine A. Rinaldi, Emma de Jong, Sally M. Lansley, Joel P.A. Gummer, Bence Olasz, Shabarinath Nambiar, Danika E. Hope, Thomas H. Casey, Y. C. Gary Lee, Connull Leslie, Gareth Nealon, David M. Shackleford, Andrew K. Powell, Marina Grimaldi, Patrick Balaguer, Rachael M. Zemek, Anthony Bosco, Matthew J. Piggott, Alice Vrielink, Richard A. Lake, W. Joost Lesterhuis
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103571- (2022)
Summary: Mesothelioma is a cancer that typically originates in the pleura of the lungs. It rapidly invades the surrounding tissues, causing pain and shortness of breath. We compared cell lines injected either subcutaneously or intrapleurally and foun
Externí odkaz:
https://doaj.org/article/6d9c2a0cd5324c82ad3d7f092e5dbba3
Autor:
M. Lizeth Orozco Morales, Catherine A. Rinaldi, Emma de Jong, Sally M. Lansley, Joel P.A. Gummer, Bence Olasz, Shabarinath Nambiar, Danika E. Hope, Thomas H. Casey, Y. C. Gary Lee, Connull Leslie, Gareth Nealon, David M. Shackleford, Andrew K. Powell, Marina Grimaldi, Patrick Balaguer, Rachael M. Zemek, Anthony Bosco, Matthew J. Piggott, Alice Vrielink, Richard A. Lake, W. Joost Lesterhuis
Publikováno v:
iScience
iScience, Vol 25, Iss 1, Pp 103571-(2022)
iScience, Vol 25, Iss 1, Pp 103571-(2022)
Summary Mesothelioma is a cancer that typically originates in the pleura of the lungs. It rapidly invades the surrounding tissues, causing pain and shortness of breath. We compared cell lines injected either subcutaneously or intrapleurally and found
CD4+ T cells drive an inflammatory, TNF-α/IFN-rich tumor microenvironment responsive to chemotherapy
Autor:
Caitlin M. Tilsed, Nicola Principe, Joel Kidman, Wee Loong Chin, M. Lizeth Orozco Morales, Rachael M. Zemek, Jonathan Chee, Rasa Islam, Vanessa S. Fear, Catherine Forbes, Wayne J. Aston, Maud Jansen, Abha Chopra, Timo Lassmann, Anna K. Nowak, Scott A. Fisher, Richard A. Lake, W. Joost Lesterhuis
Publikováno v:
Cell Reports. 41:111874
Autor:
Caitlin M, Tilsed, Nicola, Principe, Joel, Kidman, Wee Loong, Chin, M Lizeth, Orozco Morales, Rachael M, Zemek, Jonathan, Chee, Rasa, Islam, Vanessa S, Fear, Catherine, Forbes, Wayne J, Aston, Maud, Jansen, Abha, Chopra, Timo, Lassmann, Anna K, Nowak, Scott A, Fisher, Richard A, Lake, W Joost, Lesterhuis
Publikováno v:
Cell reports. 41(13)
While chemotherapy remains the first-line treatment for many cancers, it is still unclear what distinguishes responders from non-responders. Here, we characterize the chemotherapy-responsive tumor microenvironment in mice, using RNA sequencing on tum
Autor:
Caitlin M. Tilsed, M. Lizeth Orozco Morales, Rachael M. Zemek, Brianna A. Gordon, Matthew J. Piggott, Anna K. Nowak, Scott A. Fisher, Richard A. Lake, W. Joost Lesterhuis
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background Chemotherapy is included in treatment regimens for many solid cancers, but when administered as a single agent it is rarely curative. The addition of immune checkpoint therapy to standard chemotherapy regimens has improved respons
Externí odkaz:
https://doaj.org/article/604f2ab58dbd40a8bc1286fd39a00ca8
Autor:
Francois Xavier Rwandamuriye, Tao Wang, Hanfu Zhang, Omar Elaskalani, Jorren Kuster, Xueting Ye, Breana Vitali, Juliët Schreurs, M. Lizeth Orozco Morales, Marck Norret, Cameron W. Evans, Rachael M. Zemek, K. Swaminathan Iyer, W. Joost Lesterhuis, Ben Wylie
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
Toll-like receptor (TLR) agonists are being developed as anti-cancer therapeutics due to their potent immunostimulatory properties. However, clinical trials testing TLR agonists as monotherapy have often failed to demonstrate significant improvement
Externí odkaz:
https://doaj.org/article/2a3718095d18493b9813cd62cb6972ec