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Akademický článek

Differential microRNA expression analyses across two brain regions in Alzheimer’s disease

Autor: Valerija Dobricic, Marcel Schilling, Jessica Schulz, Ling-Shuang Zhu, Chao-Wen Zhou, Janina Fuß, Sören Franzenburg, Ling-Qiang Zhu, Laura Parkkinen, Christina M. Lill, Lars Bertram

Publikováno v: Translational Psychiatry, Vol 12, Iss 1, Pp 1-9 (2022)

Abstract Dysregulation of microRNAs (miRNAs) is involved in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease (AD). Hitherto, sample sizes from differential miRNA expression studies in AD are exceedingly small aggravatin

Externí odkaz: https://doaj.org/article/088589dcd113465f9ceb9238e208f34f

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Akademický článek

Cohort profile: follow-up of a Berlin Aging Study II (BASE-II) subsample as part of the GendAge study

Publikováno v: BMJ Open, Vol 11, Iss 6 (2021)

Purpose The study ‘Sex- and gender-sensitive prevention of cardiovascular and metabolic disease in older adults in Germany’, the GendAge study, focuses on major risk factors for cardiovascular and metabolic diseases and on the development of majo

Externí odkaz: https://doaj.org/article/e177d6d9adeb4e92be676cdfb8a18bde

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Akademický článek

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

Autor: Amand F. Schmidt, Michael V. Holmes, David Preiss, Daniel I. Swerdlow, Spiros Denaxas, Ghazaleh Fatemifar, Rupert Faraway, Chris Finan, Dennis Valentine, Zammy Fairhurst-Hunter, Fernando Pires Hartwig, Bernardo Lessa Horta, Elina Hypponen, Christine Power, Max Moldovan, Erik van Iperen, Kees Hovingh, Ilja Demuth, Kristina Norman, Elisabeth Steinhagen-Thiessen, Juri Demuth, Lars Bertram, Christina M. Lill, Stefan Coassin, Johann Willeit, Stefan Kiechl, Karin Willeit, Dan Mason, John Wright, Richard Morris, Goya Wanamethee, Peter Whincup, Yoav Ben-Shlomo, Stela McLachlan, Jackie F. Price, Mika Kivimaki, Catherine Welch, Adelaida Sanchez-Galvez, Pedro Marques-Vidal, Andrew Nicolaides, Andrie G. Panayiotou, N. Charlotte Onland-Moret, Yvonne T. van der Schouw, Giuseppe Matullo, Giovanni Fiorito, Simonetta Guarrera, Carlotta Sacerdote, Nicholas J. Wareham, Claudia Langenberg, Robert A. Scott, Jian’an Luan, Martin Bobak, Sofia Malyutina, Andrzej Pająk, Ruzena Kubinova, Abdonas Tamosiunas, Hynek Pikhart, Niels Grarup, Oluf Pedersen, Torben Hansen, Allan Linneberg, Tine Jess, Jackie Cooper, Steve E. Humphries, Murray Brilliant, Terrie Kitchner, Hakon Hakonarson, David S. Carrell, Catherine A. McCarty, Kirchner H. Lester, Eric B. Larson, David R. Crosslin, Mariza de Andrade, Dan M. Roden, Joshua C. Denny, Cara Carty, Stephen Hancock, John Attia, Elizabeth Holliday, Rodney Scott, Peter Schofield, Martin O’Donnell, Salim Yusuf, Michael Chong, Guillaume Pare, Pim van der Harst, M. Abdullah Said, Ruben N. Eppinga, Niek Verweij, Harold Snieder, Lifelines Cohort authors, Tim Christen, D. O. Mook-Kanamori, the ICBP Consortium, Stefan Gustafsson, Lars Lind, Erik Ingelsson, Raha Pazoki, Oscar Franco, Albert Hofman, Andre Uitterlinden, Abbas Dehghan, Alexander Teumer, Sebastian Baumeister, Marcus Dörr, Markus M. Lerch, Uwe Völker, Henry Völzke, Joey Ward, Jill P. Pell, Tom Meade, Ingrid E. Christophersen, Anke H. Maitland-van der Zee, Ekaterina V. Baranova, Robin Young, Ian Ford, Archie Campbell, Sandosh Padmanabhan, Michiel L. Bots, Diederick E. Grobbee, Philippe Froguel, Dorothée Thuillier, Ronan Roussel, Amélie Bonnefond, Bertrand Cariou, Melissa Smart, Yanchun Bao, Meena Kumari, Anubha Mahajan, Jemma C. Hopewell, Sudha Seshadri, the METASTROKE Consortium of the ISGC, Caroline Dale, Rui Providencia E. Costa, Paul M. Ridker, Daniel I. Chasman, Alex P. Reiner, Marylyn D. Ritchie, Leslie A. Lange, Alex J. Cornish, Sara E. Dobbins, Kari Hemminki, Ben Kinnersley, Marc Sanson, Karim Labreche, Matthias Simon, Melissa Bondy, Philip Law, Helen Speedy, James Allan, Ni Li, Molly Went, Niels Weinhold, Gareth Morgan, Pieter Sonneveld, Björn Nilsson, Hartmut Goldschmidt, Amit Sud, Andreas Engert, Markus Hansson, Harry Hemingway, Folkert W. Asselbergs, Riyaz S. Patel, Brendan J. Keating, Naveed Sattar, Richard Houlston, Juan P. Casas, Aroon D. Hingorani

Publikováno v: BMC Cardiovascular Disorders, Vol 19, Iss 1, Pp 1-10 (2019)

Abstract Background We characterised the phenotypic consequence of genetic variation at the PCSK9 locus and compared findings with recent trials of pharmacological inhibitors of PCSK9. Methods Published and individual participant level data (300,000+

Externí odkaz: https://doaj.org/article/6496ec7ef17e440a938a2e70da19e20c

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Akademický článek

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Multiomics profiling of human plasma and cerebrospinal fluid reveals ATN-derived networks and highlights causal links in Alzheimer's disease

Publikováno v: Alzheimer's & Dementia. Elsevier Science
Alzheimer's and Dementia. Elsevier
Shi, L, Xu, J, Green, R, Wretlind, A, Homann, J, Buckley, N J, Tijms, B M, Vos, S J B, Lill, C M, Kate, M T, Engelborghs, S, Sleegers, K, Frisoni, G B, Wallin, A, Lleó, A, Popp, J, Martinez-Lage, P, Streffer, J, Barkhof, F, Zetterberg, H, Visser, P J, Lovestone, S, Bertram, L, Nevado-Holgado, A J, Proitsi, P & Legido-Quigley, C 2023, ' Multiomics profiling of human plasma and cerebrospinal fluid reveals ATN-derived networks and highlights causal links in Alzheimer's disease ', Alzheimer's and Dementia . https://doi.org/10.1002/alz.12961
Alzheimer's & dementia

IntroductionThis study employed an integrative system and causal inference approach to explore molecular signatures in blood and CSF, the amyloid/tau/neurodegeneration [AT(N)] framework, mild cognitive impairment (MCI) conversion to Alzheimer's disea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a34d4c5501fa8a6cd064e1b903e97322
https://doi.org/10.1002/alz.12961

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Safety and efficacy of tenecteplase in patients with wake-up stroke assessed by non-contrast CT (TWIST): a multicentre, open-label, randomised controlled trial

Autor: Melinda B Roaldsen, Agnethe Eltoft, Tom Wilsgaard, Hanne Christensen, Stefan T Engelter, Bent Indredavik, Dalius Jatužis, Guntis Karelis, Janika Kõrv, Erik Lundström, Jesper Petersson, Jukka Putaala, Mary-Helen Søyland, Arnstein Tveiten, Andrew Bivard, Stein Harald Johnsen, Michael V Mazya, David J Werring, Teddy Y Wu, Gian Marco De Marchis, Thompson G Robinson, Ellisiv B Mathiesen, M Parson, M Valente, A Chen, A Sharobeam, L Edwards, C Blair, L Christensen, K Ægidius, T Pihl, C Fassel-Larsen, L Wassvik, M Folke, S Rosenbaum, S S Gharehbagh, A Hansen, N Preisler, K Antsov, S Mallene, M Lill, M Herodes, R Vibo, A Rakitin, J Saarinen, M Tiainen, O Tumpula, T Noppari, S Raty, G Sibolt, J Nieminen, J Niederhauser, I Haritoncenko, J Puustinen, T-M Haula, J Sipilä, B Viesulaite, S Taroza, D Rastenyte, V Matijosaitis, A Vilionskis, R Masiliunas, A Ekkert, P Chmeliauskas, V Lukosaitis, A Reichenbach, T T Moss, H Y Nilsen, R Hammer-Berntzen, L M Nordby, T A Weiby, K Nordengen, H Ihle-Hansen, M Stankiewiecz, O Grotle, M Nes, K Thiemann, I M Særvold, M Fraas, S Størdahl, J W Horn, H Hildrum, C Myrstad, H Tobro, J-A Tunvold, O Jacobsen, N Aamodt, H Baisa, V N Malmberg, G Rohweder, H Ellekjær, F Ildstad, E Egstad, B H Helleberg, H H Berg, J Jørgensen, E Tronvik, M Shirzadi, R Solhoff, R Van Lessen, A Vatne, K Forselv, H Frøyshov, M S Fjeldstad, L Tangen, S Matapour, K Kindberg, C Johannessen, M Rist, I Mathisen, T Nyrnes, A Haavik, G Toverud, K Aakvik, M Larsson, K Ytrehus, S Ingebrigtsen, T Stokmo, C Helander, I C Larsen, T O Solberg, Y M Seljeseth, S Maini, I Bersås, J Mathé, E Rooth, A-C Laska, A-S Rudberg, M Esbjörnsson, F Andler, A Ericsson, O Wickberg, J-E Karlsson, P Redfors, K Jood, F Buchwald, K Mansson, O Gråhamn, K Sjölin, E Lindvall, Å Cidh, A Tolf, O Fasth, B Hedström, J Fladt, T D Dittrich, L Kriemler, N Hannon, E Amis, S Finlay, J Mitchell-Douglas, J McGee, R Davies, V Johnson, A Nair, M Robinson, J Greig, O Halse, P Wilding, S Mashate, K Chatterjee, M Martin, S Leason, J Roberts, D Dutta, D Ward, R Rayessa, E Clarkson, J Teo, C Ho, S Conway, M Aissa, V Papavasileiou, S Fry, D Waugh, J Britton, A Hassan, L Manning, S Khan, A Asaipillai, C Fornolles, M L Tate, S Chenna, T Anjum, D Karunatilake, J Foot, L VanPelt, A Shetty, G Wilkes, A Buck, B Jackson, L Fleming, M Carpenter, L Jackson, A Needle, T Zahoor, T Duraisami, K Northcott, J Kubie, A Bowring, S Keenan, D Mackle, T England, B Rushton, A Hedstrom, S Amlani, R Evans, G Muddegowda, A Remegoso, P Ferdinand, R Varquez, M Davis, E Elkin, R Seal, M Fawcett, C Gradwell, C Travers, B Atkinson, S Woodward, L Giraldo, J Byers, B Cheripelli, S Lee, R Marigold, S Smith, L Zhang, R Ghatala, C H Sim, U Ghani, K Yates, S Obarey, M Willmot, K Ahlquist, M Bates, K Rashed, S Board, G Andsberg, S Sundayi, M Garside, M-J Macleod, A Manoj, O Hopper, B Cederin, T Toomsoo, K Gross-Paju, T Tapiola, J Kestutis, K-F Amthor, B Heermann, V Ottesen, T A Melum, M Kurz, M Parsons

Publikováno v: The Lancet. Neurology.

Current evidence supports the use of intravenous thrombolysis with alteplase in patients with wake-up stroke selected with MRI or perfusion imaging and is recommended in clinical guidelines. However, access to advanced imaging techniques is often sca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d77e948b8214830b257c18297ff5e11d
https://pubmed.ncbi.nlm.nih.gov/36549308

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