Zobrazeno 1 - 10
of 186
pro vyhledávání: '"M Lienhard Schmitz"'
Autor:
Michael Poppe, Sascha Wittig, Liane Jurida, Marek Bartkuhn, Jochen Wilhelm, Helmut Müller, Knut Beuerlein, Nadja Karl, Sabin Bhuju, John Ziebuhr, M Lienhard Schmitz, Michael Kracht
Publikováno v:
PLoS Pathogens, Vol 13, Iss 3, p e1006286 (2017)
Coronavirus replication takes place in the host cell cytoplasm and triggers inflammatory gene expression by poorly characterized mechanisms. To obtain more insight into the signals and molecular events that coordinate global host responses in the nuc
Externí odkaz:
https://doaj.org/article/5360acc7ff904d7fbc39af9d12d4e187
Autor:
Christin Klenke, Darius Widera, Thomas Engelen, Janine Müller, Thomas Noll, Karsten Niehaus, M Lienhard Schmitz, Barbara Kaltschmidt, Christian Kaltschmidt
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65280 (2013)
Signaling via NF-κB in neurons depends on complex formation with interactors such as dynein/dynactin motor complex and can be triggered by synaptic activation. However, so far a detailed interaction map for the neuronal NF-κB is missing. In this st
Externí odkaz:
https://doaj.org/article/f61d7f07f49e49418e8eb961bd88150b
Autor:
Holger Buss, Katja Handschick, Nadine Jurrmann, Pirita Pekkonen, Knut Beuerlein, Helmut Müller, Robin Wait, Jeremy Saklatvala, Päivi M Ojala, M Lienhard Schmitz, Michael Naumann, Michael Kracht
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51847 (2012)
Nuclear factor kappa-B (NF-κB) activates multiple genes with overlapping roles in cell proliferation, inflammation and cancer. Using an unbiased approach we identified human CDK6 as a novel kinase phosphorylating NF-κB p65 at serine 536. Purified a
Externí odkaz:
https://doaj.org/article/f0f07af112614169b2d732e1310cee77
Autor:
Maximilian Pfisterer, Roman Robert, Vera V. Saul, Amelie Pritz, Markus Seibert, Regina Feederle, M. Lienhard Schmitz
Publikováno v:
Open Biology, Vol 14, Iss 5 (2024)
The precise spatial and temporal control of histone phosphorylations is important for the ordered progression through the different phases of mitosis. The phosphorylation of H2B at S6 (H2B S6ph), which is crucial for chromosome segregation, reaches i
Externí odkaz:
https://doaj.org/article/d9c48c0e6cf1457c98b0f4f9b29b035f
Autor:
Ratnal Belapurkar, Maximilian Pfisterer, Jan Dreute, Sebastian Werner, Sven Zukunft, Ingrid Fleming, Michael Kracht, M. Lienhard SCHMITZ
Publikováno v:
Cell Death and Disease, Vol 14, Iss 7, Pp 1-15 (2023)
Abstract The family of hypoxia-inducible transcription factors (HIF) is activated to adapt cells to low oxygen conditions, but is also known to regulate some biological processes under normoxic conditions. Here we show that HIF-1α protein levels tra
Externí odkaz:
https://doaj.org/article/b515eb25605b466dac916e2efd2ae28a
Autor:
Lu Liu, Ramakanth Madhugiri, Vera Vivian Saul, Susanne Bacher, Michael Kracht, Stephan Pleschka, M. Lienhard Schmitz
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract The influenza A virus (IAV) polymerase is a multifunctional machine that can adopt alternative configurations to perform transcription and replication of the viral RNA genome in a temporally ordered manner. Although the structure of polymera
Externí odkaz:
https://doaj.org/article/617e46c449cd43499e62b64a037f70f4
Autor:
Xi Yang, Shi-Ting Wu, Rui Gao, Rui Wang, Yixuan Wang, Zhenkun Dong, Lu Wang, Chunxiao Qi, Xiaohong Wang, M. Lienhard Schmitz, Renjing Liu, Zhiming Han, Xiangjian Zheng
Publikováno v:
JCI Insight, Vol 8, Iss 5 (2023)
Loss-of-function mutations in cerebral cavernous malformation (CCM) genes and gain-of-function mutation in the MAP3K3 gene encoding MEKK3 cause CCM. Deficiency of CCM proteins leads to the activation of MEKK3-KLF2/4 signaling, but it is not clear how
Externí odkaz:
https://doaj.org/article/6556da471fa84b43b3434e6027df8a36
Autor:
Lu Liu, Axel Weber, Uwe Linne, Mahmoud Shehata, Stephan Pleschka, Michael Kracht, M. Lienhard Schmitz
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT The influenza A virus (IAV)-encoded matrix protein 1 (M1) acts as a master regulator of virus replication and fulfills multiple structural and regulatory functions in different cell compartments. Therefore, the spatiotemporal regulation of M
Externí odkaz:
https://doaj.org/article/f9c6bb616a0d46f5a09206b8abc7b2d5
Autor:
M. Lienhard Schmitz, Jan Dreute, Maximilian Pfisterer, Stefan Günther, Michael Kracht, Shashipavan Chillappagari
Publikováno v:
Heliyon, Vol 8, Iss 3, Pp e09029- (2022)
The functionally redundant ubiquitin E3 ligases SIAH1 and SIAH2 have been implicated in the regulation of metabolism and the hypoxic response, while their role in other signal-mediated processes such inflammatory gene expression remains to be defined
Externí odkaz:
https://doaj.org/article/993a3b9a555747aa87ad6b70bfc74e1f
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
The protein kinase homeodomain-interacting protein kinase 2 (HIPK2) plays an important role in development and in the response to external cues. The kinase associates with an exceptionally large number of different transcription factors and chromatin
Externí odkaz:
https://doaj.org/article/81e03d283bb442f1a5f73dbc35b4dd86