Zobrazeno 1 - 10
of 111
pro vyhledávání: '"M Leyden"'
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 6 (2024)
Background Observational epidemiological studies have reported an association between childhood adiposity and altered cardiac morphology and function in later life. However, whether this is due to a direct consequence of being overweight during child
Externí odkaz:
https://doaj.org/article/7eb5f434dfea4d92a2430f011eea098d
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108356- (2023)
Summary: Evaluating the long-term consequences of childhood lifestyle factors on asthma risk can be exceptionally challenging in epidemiology given that cases are typically diagnosed at various timepoints throughout the lifecourse. In this study, we
Externí odkaz:
https://doaj.org/article/e46e956dc2db43a1ba3ac6fd8f422507
Publikováno v:
eLife, Vol 12 (2023)
Background: Findings from Mendelian randomization (MR) studies are conventionally interpreted as lifelong effects, which typically do not provide insight into the molecular mechanisms underlying the effect of an exposure on an outcome. In this study,
Externí odkaz:
https://doaj.org/article/7f7d7a1d212447129340f2899aa4fefa
Autor:
Katie O'Nunain, Chloe Park, Helena Urquijo, Genevieve M Leyden, Alun D Hughes, George Davey Smith, Tom G Richardson
Publikováno v:
PLoS Biology, Vol 20, Iss 6, p e3001656 (2022)
Children with obesity typically have larger left ventricular heart dimensions during adulthood. However, whether this is due to a persistent effect of adiposity extending into adulthood is challenging to disentangle due to confounding factors through
Externí odkaz:
https://doaj.org/article/fb8f48620259406c910adf3049edd315
Autor:
Tom G Richardson, Genevieve M Leyden, Qin Wang, Joshua A Bell, Benjamin Elsworth, George Davey Smith, Michael V Holmes
Publikováno v:
PLoS Biology, Vol 20, Iss 2, p e3001547 (2022)
Large-scale molecular profiling and genotyping provide a unique opportunity to systematically compare the genetically predicted effects of therapeutic targets on the human metabolome. We firstly constructed genetic risk scores for 8 drug targets on t
Externí odkaz:
https://doaj.org/article/1aada819a60a4b11b8b9795af6ae1b62
Autor:
Xiaodun Li, Hayley E. Francies, Maria Secrier, Juliane Perner, Ahmad Miremadi, Núria Galeano-Dalmau, William J. Barendt, Laura Letchford, Genevieve M. Leyden, Emma K. Goffin, Andrew Barthorpe, Howard Lightfoot, Elisabeth Chen, James Gilbert, Ayesha Noorani, Ginny Devonshire, Lawrence Bower, Amber Grantham, Shona MacRae, Nicola Grehan, David C. Wedge, Rebecca C. Fitzgerald, Mathew J. Garnett
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Esophageal adenocarcinoma (EAC) has a poor 5-year survival rate and lacks robust preclinical models for use in research. Here, the authors show that newly derived organoids recapitulate the transcriptomic, genetic, and morphological landscape of the
Externí odkaz:
https://doaj.org/article/aa2121583c394435847f94d0542851c4
Autor:
Genevieve M. Leyden, Chin Yang Shapland, George Davey Smith, Eleanor Sanderson, Michael P. Greenwood, David Murphy, Tom G. Richardson
Publikováno v:
Am J Hum Genet
Body mass index (BMI) is a complex disease risk factor known to be influenced by genes acting via both metabolic pathways and appetite regulation. In this study, we aimed to gain insight into the phenotypic consequences of BMI-associated genetic vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3dec9933de57a2c84ab020f2c34d31b
https://doi.org/10.1016/j.ajhg.2021.12.013
https://doi.org/10.1016/j.ajhg.2021.12.013
Publikováno v:
Articles
Problem, research strategy, and findings: We examined whether living in a walkable neighborhood influenced the happiness of younger and older city residents. The data for this study came from a comprehensive household population survey of 1,064 adult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13281808e295f26980eb799923bb4409
https://arrow.tudublin.ie/context/beschspart/article/1031/viewcontent/Walkable_Neighborhoods.pdf
https://arrow.tudublin.ie/context/beschspart/article/1031/viewcontent/Walkable_Neighborhoods.pdf
BackgroundFindings from Mendelian randomization (MR) studies are conventionally interpreted as lifelong effects, which typically do not provide insight into the molecular mechanisms underlying the effect of an exposure on an outcome. In this study, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6eb77f0368e5c1685ac0911ff3f08db2
https://doi.org/10.1101/2022.11.29.22282906
https://doi.org/10.1101/2022.11.29.22282906
Autor:
Genevieve M. Leyden, Michael P. Greenwood, Valérie Gaborieau, Younghun Han, Christopher I. Amos, Paul Brennan, David Murphy, George Davey Smith, Tom G. Richardson
Publikováno v:
Leyden, G, Greenwood, M P, Gaborieau, V, Han, Y, Amos, C I, Brennan, P, Murphy, D, Davey Smith, G & Richardson, T G 2022, ' Disentangling the aetiological pathways between body mass index and site-specific cancer risk using tissue-partitioned Mendelian randomisation ', British Journal of Cancer . https://doi.org/10.1038/s41416-022-02060-6
Background Body mass index (BMI) is known to influence the risk of various site-specific cancers, however, dissecting which subcomponents of this heterogenous risk factor are predominantly responsible for driving disease effects has proven difficult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::affe47622a15d2998c4534ade56588db
https://research-information.bris.ac.uk/en/publications/23cde668-e9ab-4555-9017-0251f03a6953
https://research-information.bris.ac.uk/en/publications/23cde668-e9ab-4555-9017-0251f03a6953