Zobrazeno 1 - 10
of 123
pro vyhledávání: '"M Laird, Forrest"'
Publikováno v:
Engineered Regeneration, Vol 4, Iss 3, Pp 257-264 (2023)
Infections at the placement site of biomaterial-based devices and subsequent scar formation results in morbidity, which may require revision surgery. Biomaterials intended for permanent implantation in the body need to be biologically inert to avoid
Externí odkaz:
https://doaj.org/article/9dfe7ffead834c45bcd5347b1d4845d8
Autor:
Joaquina C. Baranda, Ghulam Rehman Mohyuddin, Andrés M. Bur, Yelizaveta Shnayder, Kyle R. Sweeney, Kiran Kakarala, Megan Prouty, Harsh Pathak, Rajni Puri, Amrita Mitra, Rashna Madan, M. Laird Forrest, Aric Huang, Scott Weir, Andrew K. Godwin, Nabil A. Alhakamy, J. Daniel Griffin, Cory J. Berkland
Publikováno v:
Translational Medicine Communications, Vol 8, Iss 1, Pp 1-9 (2023)
Abstract Background This window of opportunity trial evaluated the safety of intratumoral Copaxone® and profiled immune markers in biopsies before and after treatment. Methods Patients with percutaneously accessible malignancies scheduled for surgic
Externí odkaz:
https://doaj.org/article/67117a25bc5043319866b3fee0863c0e
FOXM1 transcription factor network is activated in over 84% of cases in high-grade serous ovarian cancer (HGSOC), and FOXM1 upregulates the expression of genes involved in the homologous recombination (HR) DNA damage and repair (DDR) pathway. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcb0fede9a13f23613d9afdc4ce7e033
https://doi.org/10.1158/1541-7786.c.6540421.v1
https://doi.org/10.1158/1541-7786.c.6540421.v1
The supplementary information contains 10 figures and 3 tables. Figures S1-S8 provide supplementary experimental results, describing the effect of olaparib on BRCA1 and RAD51 protein expression (Fig S1); FOXM1 isoform expression in ovarian carcinoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50d121218f7cd772553d4f4c7ae4d273
https://doi.org/10.1158/1541-7786.22513033
https://doi.org/10.1158/1541-7786.22513033
Autor:
C. Russell Middaugh, Yangjie Wei, M. Laird Forrest, Nicholas R. Larson, Gang Hu, Anthony Tuesesca
Publikováno v:
Journal of Pharmaceutical Sciences. 111:690-698
Lipid nanoparticles (LNPs) containing mRNA can deliver genetic material to cells for use as vaccines or protein replacement therapies. We characterized the effect of solution pH on cationic LNPs containing green fluorescent protein (EGFP) mRNA and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2803a7bbb75102e94fbac3a63b096768
https://doi.org/10.1016/j.xphs.2021.11.004
https://doi.org/10.1016/j.xphs.2021.11.004
Publikováno v:
Molecular pharmaceutics. 19(11)
CpG oligodeoxynucleotides are toll-like receptor 9 agonists capable of inducing potent pro-inflammatory immune responses. Although CpG oligodeoxynucleotides have shown promising antitumor effects, their systemic activity can trigger immune-related to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bad349e4cde6c989c80d4a75e15220ff
https://pubmed.ncbi.nlm.nih.gov/36282296
https://pubmed.ncbi.nlm.nih.gov/36282296
Autor:
Hebatallah Mohamed, Hebatallah Samy, Islam A. Khalil, Moustafa M. Abdelaziz, Mayar Tarek Ibrahim, Mahmoud Mustafa, Menatalla Mohamed, M. Laird Forrest, Salma B. Abdelbaky
Publikováno v:
Journal of Controlled Release. 336:410-432
With the significant drawbacks of conventional cancer chemotherapeutics, cancer immunotherapy has demonstrated the ability to eradicate cancer cells and circumvent multidrug resistance (MDR) with fewer side effects than traditional cytotoxic therapie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d2c2a3f130aa03fafd681770b84354a
https://doi.org/10.1016/j.jconrel.2021.06.025
https://doi.org/10.1016/j.jconrel.2021.06.025
Autor:
Chad Groer, Ruolin Lu, M. Laird Forrest, Aric Huang, Sebastian G. Huayamares, Melissa M. Pressnall, Brandon J. DeKosky, J. Daniel Griffin, Cory Berkland
Publikováno v:
Journal of Controlled Release. 326:203-221
Cancer therapies aim to kill tumor cells directly or engage the immune system to fight malignancy. Checkpoint inhibitors, oncolytic viruses, cell-based immunotherapies, cytokines, and adjuvants have been applied to prompt the immune system to recogni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8c55731cebcafca191177d2fd0d0605
https://doi.org/10.1016/j.jconrel.2020.06.029
https://doi.org/10.1016/j.jconrel.2020.06.029
Autor:
C. Russell Middaugh, Christian Schöneich, Yangjie Wei, M. Laird Forrest, Björn-Hendrik Peters, Ninad Varkhede
Publikováno v:
J Pharm Sci
Oxidation of therapeutic proteins (TPs) can lead to changes in their pharmacokinetics, biological activity and immunogenicity. Metal impurities such as iron are known to increase oxidation of TPs, but nanoparticulate metals have unique physical and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64ac50d60ff039ec365d6603bd30cc10
https://doi.org/10.1016/j.xphs.2019.06.007
https://doi.org/10.1016/j.xphs.2019.06.007
Autor:
Samaa Alrushaid, Casey L. Sayre, Jaime A. Yáñez, M. Laird Forrest, Sanjeewa N. Senadheera, Frank J. Burczynski, Raimar Löbenberg, Neal M. Davies
Publikováno v:
Pharmaceutics, Vol 9, Iss 3, p 35 (2017)
Doxorubicin (Dox) is an effective anti-cancer medication with poor oral bioavailability and systemic toxicities. DoxQ was developed by conjugating Dox to the lymphatically absorbed antioxidant quercetin to improve Dox’s bioavailability and tolerabi
Externí odkaz:
https://doaj.org/article/3090fddc4f504d7c9d83bde50c24e222