Výsledky vyhledávání - "M L Vera-Pedrosa"

Atrial-specific reduction of Kir2.1 channel pore diameter in addition to loss of inward-going rectification underlies inducible atrial fibrillation in a mouse model of short QT syndrome type 3

Autor: A Moreno-Manuel, A Macias, F M Cruz, L Gutierrez, I Martinez Carrascoso, F J Bermudez-Jimenez, M L Vera-Pedrosa, P Sanchez-Perez, J Bernal, J Jalife

Publikováno v: European Heart Journal. 43

Introduction Short QT Syndrome Type 3 (SQTS3) is an extremely rare arrhythmogenic disease caused by gain-of-function mutations in the KCNJ2 gene coding the inward rectifier potassium channel Kir2.1. We investigated arrhythmogenic mechanisms associate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f0fefbadb560c18769fa1ed431e31b2
https://doi.org/10.1093/eurheartj/ehac544.2970

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Three dimensional modelling of mutant Kir2.1 channel PIP2 interactions help stratify arrhythmia severity in Andersen Tawil syndrome type 1

Autor: L Gutierrez-Espinosa De Los Monteros, F Martinez, F M Cruz, A I Moreno-Manuel, P Sanchez, M L Vera-Pedrosa, I Martinez-Carrascoso, F Bermudez-Jimenez, A Macias, J Jalife

Publikováno v: European Heart Journal. 43

Background Andersen-Tawil type 1 (ATS1) is associated with loss-of-function mutations in the inward rectifier potassium channel Kir2.1, which controls cardiac excitability and impulse conduction. Phosphatidylinositol-4,5-bisphosphate (PIP2) acts as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3cfaf74fe89d58ec6e20bf90f4b73f7c
https://doi.org/10.1093/eurheartj/ehac544.365

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