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Overcoming bacterial DNA contamination in real-time PCR and RT-PCR reactions for LacZ detection in cell therapy monitoring

Autor: Jane-Lise Samuel, Sylvie Tondeur, Denise Paulin, Onnik Agbulut, Bruno Cassinat, M L Menot, Philippe Menasché, Christine Chomienne, Jérôme Larghero

Publikováno v: Molecular and Cellular Probes. 18:437-441

Since the introduction of the polymerase chain reaction the presence of contaminating bacterial DNA in the Taq polymerase preparations has hampered the use of this technique in microbiology. Lately, this inconvenience has equally impeded gene quantif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e457642b8489fdf464238ba495253635
https://doi.org/10.1016/j.mcp.2004.08.002

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Chronic myelomonocytic leukemia: from biology to therapy

Autor: André Baruchel, Christine Chomienne, Pierre Fenaux, M L Menot, Nathalie Cambier, Eric Wattel, Marie-Hélène Schlageter

Publikováno v: Europe PubMed Central

Chronic myelomonocytic leukemia represents a distinct myelodysplastic syndrome in which an excess of monocytes is observed both in the blood and bone marrow of the patients. Whereas diagnosis is relatively easy, therapeutic design and efficacy is dif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba5042818dc6fed7f1a8a5858dc071f5
https://doi.org/10.1007/s00282-997-0041-4

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Characterization of Nuclear Retinoic Acid-Binding Activity in Sensitive Leukemic-Cell Lines - Cell-Specific Uptake of Atra and Rarα Protein Modulation

Autor: B Gourmel, M. Cornic, N. Cambier, M L Menot, Christine Chomienne, M.P. Gaub, Laurent Degos, A Agadir, P Lefebvre, M. Jerome

Publikováno v: Biochemical and Biophysical Research Communications. 213:112-122

The diverse effects of all-trans retinoic acid (ATRA) on growth, differentiation and homeostasis of vertebrate organisms are mediated by three distinct isoforms of retinoic acid receptors (RARs). Although it is not known to what extent each RAR contr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3c8761ba441f7a252b83eca0ade072f
https://doi.org/10.1006/bbrc.1995.2105

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Does increasing the JAK2V617F assay sensitivity allow to identify more patients with MPN?

Autor: J J Kiladjian, Christine Dosquet, Nadine Bonnin, Bruno Cassinat, Lionel Adès, Christine Chomienne, M L Menot, Eirini Kouroupi, William Vainchenker

Publikováno v: Blood Cancer Journal

The detection of the JAK2V617F mutation has become an essential tool in BCR-ABL1-negative myeloproliferative neoplasms (MPNs) diagnosis, as it is present in 95% of polycythemia vera (PV) patients and 60% of essential thrombocytemia (ET) or myelofibro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::397c08525552bd62141b3569b2851167
https://pubmed.ncbi.nlm.nih.gov/22829972

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In vitro all-trans retinoic acid sensitivity of acute promyelocytic leukemia blasts: a novel indicator of poor patient outcome

Autor: Nicole Balitrand, Sylvie Chevret, Isabelle Guillemot, M L Menot, Fabien Zassadowski, Christine Chomienne, Bruno Cassinat, Laurent Degos, Pierre Fenaux

Publikováno v: Blood. 98:2862-2864

Acute promyelocytic leukemia (APL) blasts possess a unique sensitivity to the differentiating effects of all-transretinoic acid (ATRA). Multicenter trials confirm that the combination of differentiation and cytotoxic therapy prolongs survival in APL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d960abf6b108c350087a6d8375091ef
https://doi.org/10.1182/blood.v98.9.2862

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Germline mutations of the CBL gene define a new genetic syndrome with predisposition to juvenile myelomonocytic leukemia (JMML)

Publikováno v: Journal of Medical Genetics
Journal of Medical Genetics, BMJ Publishing Group, 2010, 47 (10), pp.686. ⟨10.1136/jmg.2010.076836⟩

Background CBL missense mutations have recently been associated with juvenile myelomonocytic leukaemia (JMML), an aggressive myeloproliferative and myelodysplastic neoplasm of early childhood characterised by excessive macrophage/monocyte proliferati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb19b07e08e6b4e9d790272b6cd6328c
https://hal.archives-ouvertes.fr/hal-00557393/file/PEER_stage2_10.1136%2Fjmg.2010.076836.pdf

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Functional G-CSF pathways in t(8;21) leukemic cells allow for differentiation induction and degradation of AML1-ETO

Autor: Nicole Balitrand, Alyssa Lebel, Laurent Degos, J.M. Miclea, M L Menot, Hervé Dombret, Da Silva N, Pierre Fenaux, Christine Chomienne, Antonio Parrado, Rousselot P, Sandrine Meyer-Monard

Publikováno v: Scopus-Elsevier

INTRODUCTION Efficacy of differentiating agents requires that their specific cellular targets are still expressed and functional in the leukemic cells. One hypothesis to target sensitive cells is to select leukemic clones which harbor disrupted trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c8da6fe7209655306d9394c223236f
https://pubmed.ncbi.nlm.nih.gov/11920209

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The V617F JAK2 Mutation Is Very Uncommon in Idiopathic Erythrocytosis

Autor: Jean-Jacques Kiladjian, Nathalie Parquet, Gerald Massonnet, Christine Chomienne, M L Menot, Bruno Cassinat

Publikováno v: Blood. 108:1295-1295

The V617F JAK2 mutation is highly frequent in Polycythemia Vera (PV) patients. Indeed, we and others found the mutation in 70 to 90% of PV patients. However one of the most difficult differential diagnoses of PV is the idiopathic erythrocytosis (IE),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::676c71af7d846d4456743d66b9ca99e6
https://doi.org/10.1182/blood.v108.11.1295.1295

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