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Akademický článek

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Alarmins and central nervous system inflammation in HIV-associated neurological disorders

Autor: M.-L. Gougeon

Publikováno v: Journal of internal medicine. 281(5)

In the era of highly active antiretroviral therapy (HAART), HIV-1-associated neurocognitive disorders (HAND) persist in infected individuals with adequate immunological and virological status. Risk factors for cognitive impairment include hepatitis C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb2cdf4cb52fe31a89559965a6caee17
https://pubmed.ncbi.nlm.nih.gov/27862491

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The tumor suppressor protein PML controls apoptosis induced by the HIV-1 envelope

Autor: J-L, Perfettini, R, Nardacci, C, Séror, M, Bourouba, F, Subra, L, Gros, G, Manic, A, Amendola, P, Masdehors, F, Rosselli, D M, Ojcius, C, Auclair, H, de Thé, M-L, Gougeon, M, Piacentini, G, Kroemer

Publikováno v: Cell Death & Differentiation. 16:298-311

Promyelomonocytic leukemia (PML) is a prominent oncosuppressor whose inactivation is involved in the pathogenesis of hematological and epithelial cancers. Here, we report that PML aggregated in nuclear bodies in syncytia elicited by the envelope glyc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18ada6bf1a81f5d13dd0a8c10aef8205
https://doi.org/10.1038/cdd.2008.158

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Peripheral V gamma 9/V delta 2 T cell deletion and anergy to nonpeptidic mycobacterial antigens in asymptomatic HIV-1-infected persons

Autor: F Poccia, S Boullier, H Lecoeur, M Cochet, Y Poquet, V Colizzi, J J Fournie, M L Gougeon

Publikováno v: The Journal of Immunology. 157:449-461

Gamma delta T cells represent a minor population of human peripheral lymphocytes, the majority of them expressing the V delta 2/V gamma 9 TCR. Their accumulation in infectious disease lesions and their reactivity toward mycobacterial Ags suggest that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::09d215dabd2f3401a003b80496dac9e6
https://doi.org/10.4049/jimmunol.157.1.449

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Programmed cell death in peripheral lymphocytes from HIV-infected persons: increased susceptibility to apoptosis of CD4 and CD8 T cells correlates with lymphocyte activation and with disease progression

Autor: M L Gougeon, H Lecoeur, A Dulioust, M G Enouf, M Crouvoiser, C Goujard, T Debord, L Montagnier

Publikováno v: The Journal of Immunology. 156:3509-3520

We analyzed the potential causes of the increased susceptibility to apoptosis of peripheral lymphocytes from a large cohort of HIV-infected persons that we followed during a 3-yr period. By using quantitative cytofluorometric methods, we demonstrate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f8093044fdb550cea8e2fa6eeeb3958e
https://doi.org/10.4049/jimmunol.156.9.3509

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Apoptosis associated with ex vivo down-regulation of Bcl-2 and up-regulation of Fas in potential cytotoxic CD8+ T lymphocytes during HIV infection

Autor: F Boudet, H Lecoeur, M L Gougeon

Publikováno v: The Journal of Immunology. 156:2282-2293

In this study, we have investigated whether the enhanced apoptosis of CD4+ and CD8+ T lymphocytes throughout HIV infection was controlled by the bcl-2 proto-oncogene, an inhibitor of programmed cell death (PCD) in mammals. We have analyzed the intrac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::91cdb013262d72ae5b8135c788744f4d
https://doi.org/10.4049/jimmunol.156.6.2282

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CDR3-independent gamma delta V delta 1+ T cell expansion in the peripheral blood of HIV-infected persons

Autor: S Boullier, M Cochet, F Poccia, M L Gougeon

Publikováno v: The Journal of Immunology. 154:1418-1431

A majority of circulating gamma delta T cells in humans express the V delta 2 variable segment associated with the V gamma 9 segment. A minor subset uses the V delta 1 gene mainly paired with a V gamma-chain from group I. Although little is known abo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a600d07fa28cab77385f339f68676fc5
https://doi.org/10.4049/jimmunol.154.3.1418

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The suppression of immune activation during enfuvirtide-based salvage therapy is associated with reduced CCR5 expression and decreased concentrations of circulating interleukin-12 and IP-10 during 48 weeks of longitudinal follow-up

Autor: J Dufayard Cottalorda, F Guillouet de Salvador, Héla Saïdi, Hélène Carsenti-Dellamonica, Rodolphe Garraffo, P. Dellamonica, Michel Ticchioni, Jacques Durant, M-L Gougeon

Publikováno v: HIV medicine. 12(2)

Background It has been suggested that patients who initiate highly active antiretroviral therapy (HAART) late in their course of infection may have suboptimal CD4 T-cell gains, persistent alterations in T-cell subsets and residual inflammation. To ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfb45a809e68170461beff0235962e95
https://pubmed.ncbi.nlm.nih.gov/20500532

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Impact of gamma-chain cytokines on T cell homeostasis in HIV-1 infection: therapeutic implications

Autor: Francesca Chiodi, M.-L. Gougeon

Publikováno v: Journal of internal medicine. 267(5)

CD4(+) T cell lymphocytes are a major target for human immunodeficiency virus type-1 (HIV-1) infection. During this chronic infection, CD4(+) T cell loss (induced through direct viral replication), generalized immune activation and increased suscepti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a61662dea11383eaceeec4c862ef2a
https://pubmed.ncbi.nlm.nih.gov/20433577

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