Zobrazeno 1 - 6
of 6
pro vyhledávání: '"M L Güler"'
Publikováno v:
The Journal of Immunology. 159:1767-1774
In this report, we examined the molecular basis underlying the genetic difference between BALB/c and B10.D2 T cells for T helper phenotype development in vitro. We found a strain-dependent difference in early maintenance of IL-12 responsiveness by T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef2072702ed8bfcfa83048a8a5d967ad
https://doi.org/10.4049/jimmunol.159.4.1767
https://doi.org/10.4049/jimmunol.159.4.1767
Publikováno v:
The Journal of Immunology. 156:1442-1447
IL-12 and IL-4 direct T cell development toward Th1 and Th2 phenotypes, respectively. While IFN-gamma and IFN-alpha have been reported to regulate Th1 development as well, the mechanism and cellular locus of their effects are unclear. In this study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76fdfd27291a2f2993777b0f0573bd61
https://doi.org/10.4049/jimmunol.156.4.1442
https://doi.org/10.4049/jimmunol.156.4.1442
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 161(4)
Expression of IL-12Rs is one important checkpoint for Th1 development. BALB/c DO11.10 CD4+ T cells stimulated by Ag in neutral conditions lose expression of the IL-12R beta 2 subunit and become unresponsive to IL-12. In contrast, B10.D2 or F1 (BALB/c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::710dbfab0435c9fcd42f564bbe01b21f
https://pubmed.ncbi.nlm.nih.gov/9712029
https://pubmed.ncbi.nlm.nih.gov/9712029
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 159(4)
In this report, we examined the molecular basis underlying the genetic difference between BALB/c and B10.D2 T cells for T helper phenotype development in vitro. We found a strain-dependent difference in early maintenance of IL-12 responsiveness by T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::33af145e638d2f21f855f33e768956fe
https://pubmed.ncbi.nlm.nih.gov/9257839
https://pubmed.ncbi.nlm.nih.gov/9257839
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 156(4)
IL-12 and IL-4 direct T cell development toward Th1 and Th2 phenotypes, respectively. While IFN-gamma and IFN-alpha have been reported to regulate Th1 development as well, the mechanism and cellular locus of their effects are unclear. In this study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5b4cb2aa581849a77b3c889534b959cf
https://pubmed.ncbi.nlm.nih.gov/8568246
https://pubmed.ncbi.nlm.nih.gov/8568246
Publikováno v:
Advances in experimental medicine and biology. 409
The experiments described above have allowed us to define the molecular events in IL-12 signalling. Within minutes after IL-12 treatment of responsive cells, Stat1, Stat3, and Stat4 are tyrosine phosphorylated. These molecules form nuclear DNA-bindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8f6ea37e405465ba4ddc729a9cc0f404
https://pubmed.ncbi.nlm.nih.gov/9095224
https://pubmed.ncbi.nlm.nih.gov/9095224