Výsledky vyhledávání - "M L Constanzer"

Indirect chiral separation and analyses in human biological fluids of the stereoisomers of a thienothiopyran-2-sulfonamide (TRUSOPT), a novel carbonic anhydrase inhibitor with two chiral centers in the molecule

Autor: M. L. Constanzer, B. K. Matuszewski

Publikováno v: Chirality. 4:515-519

The indirect chiral separation of the four stereoisomers (1)-(4) of a novel carbonic anhydrase inhibitor with two chiral centers in the molecule is reported. The method is based on chemical derivatization of the secondary amino group of the inhibitor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3fc70d9c8cbc549a564ff9734286d25
https://doi.org/10.1002/chir.530040810

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Matrix effect in quantitative LC/MS/MS analyses of biological fluids: a method for determination of finasteride in human plasma at picogram per milliliter concentrations

Autor: B K, Matuszewski, M L, Constanzer, C M, Chavez-Eng

Publikováno v: Analytical chemistry. 70(5)

Contrary to common perceptions, the reliability of quantitative assays for the determination of drugs in biological fluids using high-performance liquid chromatography with tandem mass spectrometric (LC/MS/MS) detection methods and the integrity of r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::96b013e415aa52405728fa405a43bbea
https://pubmed.ncbi.nlm.nih.gov/9511465

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Effect of MK-386, a novel inhibitor of type 1 5 alpha-reductase, alone and in combination with finasteride, on serum dihydrotestosterone concentrations in men

Autor: E C Shamblen, S J Justice, Gregory A. Winchell, C M Chavez, Daniel Z. Wang, K. C. Lasseter, David L. Ebel, A. Van Hecken, I De Lepeleire, M L Constanzer, Jules I. Schwartz, Barry J. Gertz, P. J. De Schepper

Publikováno v: The Journal of clinical endocrinology and metabolism. 81(8)

Two isozymes (types 1 and 2) of 5 alpha-reductase (5 alpha R; EC 1.3.99.5), with differential tissue distribution, have been identified in humans. These enzymes catalyze the reduction of testosterone (T) to dihydrotestosterone (DHT). The contribution

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4765b881561dc7d717399590815cbf0
https://pubmed.ncbi.nlm.nih.gov/8768856

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Analytical chiral separation of the stereoisomers of a novel carbonic anhydrase inhibitor and its deethylated metabolite, and the assignment of absolute configuration of the human metabolite and chiral degradation products

Autor: B K, Matuszewski, M L, Constanzer, M, Kiganda

Publikováno v: Pharmaceutical research. 11(3)

Several approaches to the separation of four stereoisomers, 1-4, of a novel, topically active, carbonic anhydrase inhibitor, 1, with two chiral centers in the molecule and four isomers, 5-8, of its chiral metabolite, 5, were evaluated. These methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e4649cba4f05ee5b665b9b9d1d81e348
https://pubmed.ncbi.nlm.nih.gov/8008715

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Topical MK-386 (M), an inhibitor of 5α-reductase (5αr) type I, suppresses sebum dht

Autor: Daniel Z. Wang, David L. Ebel, Wesley Tanaka, Jules I. Schwartz, Mary Flynn, S. Adcock, M L Constanzer, Barry J. Gertz, Gregory A. Winchell

Publikováno v: Clinical Pharmacology & Therapeutics. 59:166-166

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78bbe2e42bc8e22e2175bced65d65483
https://doi.org/10.1038/sj.clpt.1996.165

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Single-dose pharmacokinetics and bioavailability of famotidine in man. Results of multicenter collaborative studies

Autor: A. N. Chremos, R. L. Williams, J. Antonello, J. R. Ryan, M. L. Constanzer, K. C. Yeh, J. H. Lin, H. B. Hucker, S. M. Kanovsky, P. Vlasses

Publikováno v: Biopharmaceutics & Drug Disposition. 8:549-560

Pharmacokinetics and bioavailability of famotidine, a new H2-receptor antagonist, were investigated in healthy subjects in five clinical studies. Linear pharmacokinetics were observed following either intravenous or oral administration. Plasma cleara

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71322f9704945d1eafa025324c19e145
https://doi.org/10.1002/bdd.2510080606

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