Zobrazeno 1 - 10
of 11
pro vyhledávání: '"M L, Veigl"'
Autor:
A. Polinkovsky, G. Lader, Paul Modrich, Liang Xia, J. Olechnowicz, Susan J. Littman, S. Swinler, Lakshmi Kasturi, Sanford D. Markowitz, W. D. Sedwick, James Lutterbaugh, A.-H. Ma, M. L. Veigl
Publikováno v:
Oncogene. 19:2249-2256
Inactivation of DNA-mismatch repair underlies the genesis of microsatellite unstable (MSI) colon cancers. hPMS2 is one of several genes encoding components of the DNA-mismatch repair complex, and germline hPMS2 mutations have been found in a few kind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ce5c543dccc100d0675502de74b5107
https://doi.org/10.1038/sj.onc.1203568
https://doi.org/10.1038/sj.onc.1203568
Autor:
T, Yan, J E, Schupp, H S, Hwang, M W, Wagner, S E, Berry, S, Strickfaden, M L, Veigl, W D, Sedwick, D A, Boothman, T J, Kinsella
Publikováno v:
Cancer research. 61(22)
Our previous data demonstrated that cells deficient in MutL homologue-1 (MLH1) expression had a reduced and shorter G(2) arrest after high-dose-rate ionizing radiation (IR), suggesting that the mismatch re pair (MMR) system mediates this cell cycle c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::165917711c3ed10897afe6e3b936a0b4
https://pubmed.ncbi.nlm.nih.gov/11719462
https://pubmed.ncbi.nlm.nih.gov/11719462
Autor:
J R, Eshleman, S D, Markowitz, P S, Donover, E Z, Lang, J D, Lutterbaugh, G M, Li, M, Longley, P, Modrich, M L, Veigl, W D, Sedwick
Publikováno v:
Oncogene. 12(7)
Colon cancer and an increasing number of other cancers have been found to exhibit instability of DNA microsatellite sequences. Such tumors have been designated as replication errors (RER) tumors. However, as microsatellites are only rarely found with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ff0e5d17715aef3eab50852f825404cc
https://pubmed.ncbi.nlm.nih.gov/8622858
https://pubmed.ncbi.nlm.nih.gov/8622858
Autor:
J R, Eshleman, E Z, Lang, G K, Bowerfind, R, Parsons, B, Vogelstein, J K, Willson, M L, Veigl, W D, Sedwick, S D, Markowitz
Publikováno v:
Oncogene. 10(1)
Hereditary Non-Polyposis Colon Cancer (HNPCC) tumors and some sporadic colon cancers acquire somatic changes in the length of microsatellite sequences. We hypothesized that this 'replication error' (RER) phenotype in these cancers reflects a more gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b2cc426c27e81bde2c39d3b386ae6fe6
https://pubmed.ncbi.nlm.nih.gov/7824277
https://pubmed.ncbi.nlm.nih.gov/7824277
Publikováno v:
Cancer research. 53(5)
The human O6-alkylguanine-DNA alkyltransferase complementary DNA was transfected into the alkyltransferase-deficient Chinese hamster ovary cell line, D422, in an effort to dissect the underlying mechanisms of bischloroethylnitrosourea (BCNU)-induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::abe157b0b59d0015a81abab76b58cad4
https://pubmed.ncbi.nlm.nih.gov/8439973
https://pubmed.ncbi.nlm.nih.gov/8439973
Mutational specificity of 1,3-bis-(2-chloroethyl)-1-nitrosourea in a Chinese hamster ovary cell line
Publikováno v:
Cancer research. 52(17)
The mutational specificity of the alkylating agent 1-3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) was analyzed at the endogenous hemizygous adenine phosphoribosyl transferase gene of the Chinese hamster ovary cell line D422. A 1-h treatment of the Chin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ec58599043be83cda8c75321ad5fa6f3
https://pubmed.ncbi.nlm.nih.gov/1511435
https://pubmed.ncbi.nlm.nih.gov/1511435
Publikováno v:
Cancer research. 51(15)
In the absence of excision repair, doxorubicin caused a striking (41-fold) increase in the frequency of large deletion mutations extending from the lac operator (lacO) into the lac repressor gene (lacI) of Escherichia coli. In contrast, there was onl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::91656396b6f406003281ac9f3e6708c4
https://pubmed.ncbi.nlm.nih.gov/1855210
https://pubmed.ncbi.nlm.nih.gov/1855210
Publikováno v:
Mutation research. 246(1)
The antifolate, trimethoprim (TRMP, 5 microM) caused a 10-fold increase in mutation frequency and primarily induced base substitution and deletion mutations in wild-type E. coli. Base-substitutions induced by antifolates were equally divided between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e48a0f3eea5cb28fa196827a9b22a30f
https://pubmed.ncbi.nlm.nih.gov/1986269
https://pubmed.ncbi.nlm.nih.gov/1986269
Publikováno v:
Federation proceedings. 41(7)
Numerous lines of evidence implicate calcium and calmodulin (CaM) as regulators of cell growth and functional differentiation. In light of this evidence, several studies of the possible involvement of the CaM system in cellular transformation by RNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2a07c2bee2909ef324184236cfb54ee6
https://pubmed.ncbi.nlm.nih.gov/6281082
https://pubmed.ncbi.nlm.nih.gov/6281082
Differences in calmodulin levels of normal and transformed cells as determined by culture conditions
Publikováno v:
Cancer research. 44(8)
Several studies have suggested that calmodulin (CAM) levels increase in cells as a consequence of transformation by RNA tumor viruses. This study examines factors affecting CAM levels in normal and transformed chick embryo fibroblasts. Significant di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ee1a393363bd1b35c898928493bd4b94
https://pubmed.ncbi.nlm.nih.gov/6331640
https://pubmed.ncbi.nlm.nih.gov/6331640