Zobrazeno 1 - 10
of 25
pro vyhledávání: '"M L, Schwartzman"'
Autor:
Yan Lavrovsky, M. E. Gerritsen, Richard D. Levere, Shigeki Shibahara, M L Schwartzman, Nader G. Abraham, Attallah Kappas, R A Stoltz
Publikováno v:
Proceedings of the National Academy of Sciences. 92:6798-6802
Heme oxygenase (HO) is a stress protein and has been suggested to participate in defense mechanisms against agents that may induce oxidative injury such as metals, endotoxin, heme/hemoglobin, and various cytokines. Overexpression of HO in cells might
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 267:R579-R589
The renal metabolism of arachidonic acid (AA) was compared in male and female prehypertensive Dahl salt-sensitive (SS/Jr) and salt-resistant (SR/Jr) rats maintained on a low- (0.3%) sodium chloride diet. Renal cortical microsomes incubated with AA pr
Publikováno v:
Scopus-Elsevier
In the hematopoietic system the adherent stromal cells produce cytokines necessary for proliferation and differentiation of hematopoietic cells. In the present study, we showed the ability of adherent stromal cells to generate novel metabolites of ar
Publikováno v:
Investigative ophthalmologyvisual science. 42(2)
Increased production of 12-hydroxyeicosatetraenoic acid [12(R)-HETE] and 12-hydroxyeicosatrienoic acid [12(R)-HETrE] positively correlates with the in vivo progression of ocular surface inflammation in rabbits. Tear film was collected from human subj
Publikováno v:
Investigative ophthalmologyvisual science. 41(8)
Injury to the corneal epithelium increases arachidonic acid (AA) metabolism through the cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 pathways. The authors used the rabbit corneal organ culture model to demonstrate the effect of hypox
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 289(3)
The corneal epithelium metabolizes arachidonic acid by a cytochrome P-450 (CYP)-mediated activity to 12-hydroxy-5,8,11, 14-eicosatetraenoic acid (12(R)-HETE) and 12-hydroxy-5,8, 14-eicosatrienoic acid (12(R)-HETrE ). Both metabolites possess potent i
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 287(3)
The corneal epithelium metabolizes arachidonic acid by a cytochrome P450-(CYP) mediated pathway to 12(R)hydroxy-5,8,10,14-eicosatrienoic acid [12(R)-HETE] and 12(R)hydroxy-5,8,14-eicosatrienoic acid [12(R)-HETrE]. Both metabolites possess potent infl
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 284(3)
We characterized the inhibitory activity of several acetylenic and olefinic compounds on cytochrome P450 (CYP)-derived arachidonic acid omega-hydroxylation and epoxidation using rat renal cortical microsomes and recombinant CYP proteins. Among the ac
Publikováno v:
Investigative ophthalmologyvisual science. 38(10)
Alkali burning of the rabbit cornea is a well-established model for the study of anterior surface inflammation, neovascularization, and wound-healing processes. 12-hydroxyeicosanoids have been implicated as mediators of such responses. 12(S)-hydroxye
Autor:
N G, Abraham, J L, da Silva, Y, Lavrovsky, R A, Stoltz, A, Kappas, M W, Dunn, M L, Schwartzman
Publikováno v:
Investigative ophthalmologyvisual science. 36(11)
Heme oxygenase-1 (HO-1) is a stress protein induced up to 100-fold within a few hours after exposure to oxidative stress, and it has been shown to counteract oxidative injury induced by ultraviolet light or free radicals. The current study was undert