Levosimendan in septic shock in patients with biochemical evidence of cardiac dysfunction: a subgroup analysis of the LeoPARDS randomised trial

Autor: Gavin D. Perkins, Deborah Ashby, Alexina J. Mason, Mary Cross, Robert M L Orme, Anthony C. Gordon, Josie K Ward, Kieran P. O'Dea, Mervyn Singer, Shalini Santhakumaran, David Antcliffe, Farah Al-Beidh, Daniel F. McAuley

Publikováno v: Intensive care medicine. 45(10)

Purpose\ud Myocardial dysfunction is common in sepsis but optimal treatment strategies are unclear. The inodilator, levosimendan was suggested as a possible therapy; however, the levosimendan to prevent acute organ dysfunction in Sepsis (LeoPARDS) tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::684777be09fc6afbba1033b784252925
https://pubmed.ncbi.nlm.nih.gov/31428804

An unusual case of Escherichia coli O157:H7 infection with pseudomembranous colitis-like lesions associated with haemolytic-uraemic syndrome and neurological sequelae

Autor: Lauren Simmonds, Warren Doherty, James Kennedy, Robert M L Orme

A 75-year-old man was admitted with abdominal pain and fresh rectal bleeding. Significantly, he had no risk factors for Clostridium difficile infection. An abdominal CT demonstrated colonic thickening, and flexible sigmoidoscopy identified pseudomemb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d404e81a44baffbfe50f20de69e2bde
https://europepmc.org/articles/PMC5534687/

An efficacy and mechanism evaluation study of Levosimendan for the Prevention of Acute oRgan Dysfunction in Sepsis (LeoPARDS): Protocol for a randomized controlled trial

Autor: Alexina J. Mason, Robert M L Orme, Andrea Morelli, Daniel F. McAuley, Gavin D. Perkins, Anthony C. Gordon, Deborah Ashby, Mervyn Singer, Kathleen D. Liu

Publikováno v: L'E Orme, R M, Perkins, G D, McAuley, D F, Liu, K D, Mason, A J, Morelli, A, Singer, M, Ashby, D & Gordon, A C 2014, ' An efficacy and mechanism evaluation study of Levosimendan for the Prevention of Acute oRgan Dysfunction in Sepsis (LeoPARDS): Protocol for a randomized controlled trial ', Trials, vol. 15, 199 . https://doi.org/10.1186/1745-6215-15-199
Trials
ResearcherID

BACKGROUND: Organ dysfunction consequent to infection ('severe sepsis') is the leading cause of admission to an intensive care unit (ICU). In both animal models and early clinical studies the calcium channel sensitizer levosimendan has been demonstra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cbc66b0f4dd4982c4765c57d999ff8d
https://pure.qub.ac.uk/en/publications/an-efficacy-and-mechanism-evaluation-study-of-levosimendan-for-the-prevention-of-acute-organ-dysfunction-in-sepsis-leopards-protocol-for-a-randomized-controlled-trial(0e2951ec-d850-41fa-9ea9-0b42a9daa03d).html

Supplementary Oxygen and the Laryngeal Mask Airway—Evaluation of a Heat-and-Moisture Exchanger

Autor: M. Williams, R. M. L. Orme

Publikováno v: Anaesthesia and Intensive Care. 27:509-511

Heat-and-moisture exchangers (HMEs) are routinely used in anaesthesia for the humidification and warming of inspired gases. The use of the Laryngeal Mask Airway (LMA) is widespread, and many anaesthetists choose to leave it in situ until the patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a00d9b6aa5988965ac081f688b939f2
https://doi.org/10.1177/0310057x9902700513

Clinical pharmacology and primary health care in Europe ? a gap to bridge

Autor: H. Wesseling, M L Orme, P. K. M. Lunde, A. Melander, G. Tognoni, Folke Sjöqvist, G. Dukes

Publikováno v: European Journal of Clinical Pharmacology. 38:315-318

A group of senior European clinical pharmacologists presents a position paper on the possible role of clinical pharmacology (CP) in bridging the gap between academic drug evaluation and drug prescribing in primary health care (PHC). As a teaching, re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ce052924318da2b01ba492a199fe6ba
https://doi.org/10.1007/bf00315567