Výsledky vyhledávání - "M L, McDaniel"

Identifying the links between obesity, insulin resistance and β-cell function: potential role of adipocyte-derived cytokines in the pathogenesis of type 2 diabetes

Autor: Andrew S. Greenberg, M. L. McDaniel

Publikováno v: European Journal of Clinical Investigation. 32:24-34

A combination of insulin resistance and pancreatic beta-cell dysfunction underlies most cases of type 2 diabetes. While the interplay of these two impairments is believed to be important in the development and progression of type 2 diabetes, the mech

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd9afcdf4109ed6768ca4faea7ca0b6e
https://doi.org/10.1046/j.1365-2362.32.s3.4.x

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Identifying the links between obesity, insulin resistance and beta-cell function: potential role of adipocyte-derived cytokines in the pathogenesis of type 2 diabetes

Autor: A S, Greenberg, M L, McDaniel

Publikováno v: European journal of clinical investigation. 32

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::39f8d7f3a4cda6b006824958cb8ba2d1
https://pubmed.ncbi.nlm.nih.gov/12028372

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Glucose and insulin stimulate heparin-releasable lipoprotein lipase activity in mouse islets and INS-1 cells. A potential link between insulin resistance and beta-cell dysfunction

Autor: W S, Cruz, G, Kwon, C A, Marshall, M L, McDaniel, C F, Semenkovich

Publikováno v: The Journal of biological chemistry. 276(15)

Lipoprotein lipase (LpL) provides tissues with triglyceride-derived fatty acids. Fatty acids affect beta-cell function, and LpL overexpression decreases insulin secretion in cell lines, but whether LpL is regulated in beta-cells is unknown. To test t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9ba667d7efaefe211b9778865427719d
https://pubmed.ncbi.nlm.nih.gov/11154699

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Tumor necrosis factor alpha-induced pancreatic beta-cell insulin resistance is mediated by nitric oxide and prevented by 15-deoxy-Delta12,14-prostaglandin J2 and aminoguanidine. A role for peroxisome proliferator-activated receptor gamma activation and inos expression

Autor: G, Kwon, G, Xu, C A, Marshall, M L, McDaniel

Publikováno v: The Journal of biological chemistry. 274(26)

Recent studies have identified a beta-cell insulin receptor that functions in the regulation of protein translation and mitogenic signaling similar to that described for insulin-sensitive cells. These findings have raised the novel possibility that b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8b4f9c469db0c5ac36281b8c1001cb48
https://pubmed.ncbi.nlm.nih.gov/10373483

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Branched-chain amino acids are essential in the regulation of PHAS-I and p70 S6 kinase by pancreatic beta-cells. A possible role in protein translation and mitogenic signaling

Autor: G, Xu, G, Kwon, C A, Marshall, T A, Lin, J C, Lawrence, M L, McDaniel

Publikováno v: The Journal of biological chemistry. 273(43)

Amino acids have been identified as important signaling molecules involved in pancreatic beta-cell proliferation, although the cellular mechanism responsible for this effect is not well defined. We previously reported that amino acids are required fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::57e3598f9ff1b38827eee7097b646de9
https://pubmed.ncbi.nlm.nih.gov/9774438

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