Biomarkers associated with early stages of kidney disease in adolescents with type 1 diabetes

Autor: Andrew Neil, Kim C. Donaghue, Sally M. Marshall, Maria E. Craig, Jennifer J Couper, Paul M. McKeigue, Fergus J. Cameron, Denis Daneman, Timothy W. Jones, Paul Z. Benitez-Aguirre, Marco Colombo, Scott T Chiesa, Elizabeth A. Davis, Helen M. Colhoun, David B. Dunger, M. L. Marcovecchio, John E. Deanfield, Farid H. Mahmud, Raymond Neil Dalton

Publikováno v: 2020, ' Biomarkers associated with early stages of kidney disease in adolescents with type 1 diabetes ', Pediatric Diabetes . https://doi.org/10.1111/pedi.13095

OBJECTIVES: To identify biomarkers of renal disease in adolescents with type 1 diabetes (T1D) and to compare findings in adults with T1D.METHODS: Twenty-five serum biomarkers were measured, using a Luminex platform, in 553 adolescents (median [interq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee30256d16fc43d8d9c64c93a523b734
https://doi.org/10.1111/pedi.13095

Editorial: Debates in Clinical Management in Pediatric Endocrinology

Autor: Gianpaolo De Filippo, M. L. Marcovecchio, Maurizio Delvecchio, Barbara Predieri

Publikováno v: Frontiers in Endocrinology, Vol 12 (2021)

Over the last decades the diagnosis and management of pediatric endocrine disorders has substantially improved. However, clinicians still face some key challenges, without straightforward solutions, during their daily clinical practice. This Research

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feee9bebfaf7df4800594c2cb5ba5160
https://doi.org/10.3389/fendo.2021.663860

One-hour post-load plasma glucose levels associated with decreased insulin sensitivity and secretion and early makers of cardiometabolic risk

Autor: M. L. Marcovecchio, Angelika Mohn, Valentina Chiavaroli, M. Bagordo, E. Marisi, T. de Giorgis, Francesco Chiarelli

PURPOSE: Obese adults with normal glucose tolerance (NGT) but with 1-hour post-load plasma glucose (1hPG) ≥ 155 mg/dl are at higher risk of developing type 2 diabetes (T2D) and cardiometabolic complications. Little information is available for the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f23fe39527307a9f2280587ac8dddf32

Interleukin-2 Therapy of Autoimmunity in Diabetes (ITAD): a phase 2, multicentre, double-blind, randomized, placebo-controlled trial

Autor: Susan J Dutton, John A. Todd, Linda S. Wicker, Johnson Prv., Claire Scudder, M. L. Marcovecchio, S Kopijasz, David B. Dunger

Publikováno v: Wellcome Open Research

Type 1 diabetes is a common autoimmune disease due to destruction of pancreatic β cells, resulting in lifelong need for insulin. Evidence suggest that maintaining residual β-cell function can improve glucose control and reduce risk of hypoglycaemia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0426b047d4eeffb91c5b89f90cdb428
https://doi.org/10.12688/wellcomeopenres.15697.1

Blood pressure from childhood to adolescence in obese youths in relation to insulin resistance and asymmetric dimethylarginine

Autor: M. L. Marcovecchio, Valentina Chiavaroli, Cosimo Giannini, Francesco Chiarelli, T. de Giorgis, Angelika Mohn

Publikováno v: Journal of Endocrinological Investigation. 39:169-176

Hypertension is the most important cardiovascular complication of obesity, even during childhood. Several studies have demonstrated that there is a natural progression of hypertension from childhood to adulthood. However, there are no data reporting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59dd2f0ea4a10e8785676300e0ef1ed6
https://doi.org/10.1007/s40618-015-0351-2