Zobrazeno 1 - 10
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pro vyhledávání: '"M L, DePamphilis"'
Autor:
M L, DePamphilis
Publikováno v:
Current topics in developmental biology. 120
Nothing is more fundamental to mammalian development than the ability to accurately reproduce its genome once-but only once-each time a cell divides. In fact, the basic mechanism for replicating DNA has been conserved throughout evolution, even thoug
Publikováno v:
Cold Spring Harbor perspectives in biology. 5(1)
Developmentally programmed polyploidy occurs by at least four different mechanisms, two of which (endoreduplication and endomitosis) involve switching from mitotic cell cycles to endocycles by the selective loss of mitotic cyclin-dependent kinase (CD
Specific transcription factors stimulate simian virus 40 and polyomavirus origins of DNA replication
Autor:
Zong Sheng Guo, M. L. Depamphilis
Publikováno v:
Molecular and Cellular Biology. 12:2514-2524
The origins of DNA replication (ori) in simian virus 40 (SV40) and polyomavirus (Py) contain an auxiliary component (aux-2) composed of multiple transcription factor binding sites. To determine whether this component stimulated replication by binding
Publikováno v:
Journal of cellular physiology. 184(2)
The mechanism for initiation of eukaryotic DNA replication is highly conserved: the proteins required to initiate replication, the sequence of events leading to initiation, and the regulation of initiation are remarkably similar throughout the eukary
Autor:
M L, DePamphilis
Publikováno v:
BioEssays : news and reviews in molecular, cellular and developmental biology. 21(1)
The process by which eukaryotic cells decide when and where to initiate DNA replication has been illuminated in yeast, where specific DNA sequences (replication origins) bind a unique group of proteins (origin recognition complex) next to an easily u
Autor:
M L, DePamphilis
Publikováno v:
Journal of cellular biochemistry. Supplement.
Our understanding of the process by which eukaryotes regulate initiation of DNA replication has made remarkable advances in the past few years, thanks in large part to the explosion of genetic and biochemical information on the budding yeast, Sacchar
Autor:
K J, Kaneko, M L, DePamphilis
Publikováno v:
Developmental genetics. 22(1)
In mouse development, transcription is first detected in late 1-cell embryos, but translation of newly synthesized transcripts does not begin until the 2-cell stage. Thus, the onset of zygotic gene expression (ZGE) is regulated at the level of both t
Autor:
M L, DePamphilis
Publikováno v:
Methods (San Diego, Calif.). 13(3)
Publikováno v:
The EMBO journal. 15(20)
Zygotic gene expression in mice is delayed by a time-dependent mechanism until the two-cell stage in development. To investigate the basis of this 'zygotic clock', the firefly luciferase gene was injected into mouse embryos, and quantitative assays w
Autor:
M L, DePamphilis
Publikováno v:
Methods in enzymology. 262