Zobrazeno 1 - 10
of 75
pro vyhledávání: '"M L, Cuzner"'
Publikováno v:
Neuropathology and Applied Neurobiology. 34:216-230
During neuroinflammation in multiple sclerosis (MS) fibrinogen, not normally present in the brain or spinal cord, enters the central nervous system through a compromised blood-brain barrier. Fibrin deposited on axons is ineffectively removed by tissu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::237abe1fb64bca869f71ed364decd322
https://doi.org/10.1111/j.1365-2990.2007.00889.x
https://doi.org/10.1111/j.1365-2990.2007.00889.x
Publikováno v:
Neuropathology and Applied Neurobiology. 32:15-22
In multiple sclerosis (MS), the matrix metalloprotease (MMP) gelatinase B/MMP-9 and platelet endothelial cell adhesion molecule (PECAM)-1 have both been implicated in trans-endothelial infiltration of leucocytes into the brain, but their functional c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1cd6e2ad80f69b380dd8d746aa37c71
https://doi.org/10.1111/j.1365-2990.2006.00677.x
https://doi.org/10.1111/j.1365-2990.2006.00677.x
Autor:
Gareth J. Barker, J. Newcombe, W. I. McDonald, M Clemence, Klaus Schmierer, Roger J. Ordidge, M. L. Cuzner, Ps Tofts, Francesco Scaravilli, J. P. Mottershead, John S. Thornton, DH Miller
Publikováno v:
Journal of Neurology. 250:1293-1301
Different MRI techniques are used to investigate multiple sclerosis (MS) in vivo. The pathological specificity of these techniques is poorly understood, in particular their relationship to demyelination and axonal loss. The aim of this study was to e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e12ee0bd7d416ba6d87cb7533884c85
https://doi.org/10.1007/s00415-003-0192-3
https://doi.org/10.1007/s00415-003-0192-3
Publikováno v:
Neuropathology and Applied Neurobiology. 29:434-444
Dense astrocytic scarring in chronic multiple sclerosis (MS) plaques produces an inhibitory environment which can impede tissue repair. Animal studies have shown that the antigenic phenotype of the most abundant cell type in the brain, the astrocyte,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9633f0aae1a2acb7db79071ad5ad5f9a
https://doi.org/10.1046/j.1365-2990.2003.00491.x
https://doi.org/10.1046/j.1365-2990.2003.00491.x
Autor:
Chris H. Polman, M. L. Cuzner, Axel Petzold, Gavin Giovannoni, Djordje Gveric, B. M. J. Uitdehaag, R.H.C. Lazeron, Miles D. Chapman, M.J. Eikelenboom, Geoffrey Keir, E. J. Thompson
Publikováno v:
Brain. 125:1462-1473
Disease progression in multiple sclerosis occurs within the interface of glial activation and gliosis. This study aimed to investigate the relationship between biomarkers of different glial cell responses: (i) to disease dynamics and the clinical sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019666e2a66b9061e4e050fcd35702b8
https://doi.org/10.1093/brain/awf165
https://doi.org/10.1093/brain/awf165
Autor:
Federico Turkheimer, Graeme M. Bydder, T. Smith, Gavin Giovannoni, A. K. Hewson, Roger N. Gunn, Terry Jones, F. Wegner, Richard B. Banati, Ralph Myers, David Miller, Jia Newcombe, Georg W. Kreutzberg, G. D. Perkin, M. L. Cuzner, G. Price, Annachiara Cagnin, Frank L. Heppner
Publikováno v:
Brain. 123:2321-2337
This study identifies by microautoradiography activated microglia/macrophages as the main cell type expressing the peripheral benzodiazepine binding site (PBBS) at sites of active CNS pathology. Quantitative measurements of PBBS expression in vivo ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98e9ea61c9367478fc48466271649019
https://doi.org/10.1093/brain/123.11.2321
https://doi.org/10.1093/brain/123.11.2321
Publikováno v:
Proceedings of the National Academy of Sciences. 97:11598-11602
Clinical abnormalities in multiple sclerosis (MS) have classically been considered to be caused by demyelination and/or axonal degeneration; the possibility of molecular changes in neurons, such as the deployment of abnormal repertoires of ion channe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de49c86afe0fb28bab912e71cdf97ac3
https://doi.org/10.1073/pnas.97.21.11598
https://doi.org/10.1073/pnas.97.21.11598
Publikováno v:
Neuropathology and Applied Neurobiology. 25:215-225
Insulin-like growth factors (IGFs) play an important role in development and myelination in the central nervous system (CNS) as well as in the proliferation and differentiation of cells of the immune system. To assess the influence of this growth fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2867211b3faa260f07a4423a721b4fde
https://doi.org/10.1046/j.1365-2990.1999.00187.x
https://doi.org/10.1046/j.1365-2990.1999.00187.x
Publikováno v:
Journal of Autoimmunity. 9:167-174
The adrenocortical response is central to recovery from experimental allergic encephalomyelitis (EAE) in the Lewis rat, as reflected by the increased severity of the disease in adrenalectomized animals. The protection conferred by glucocorticoids is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1494df33676aa78a53cc5d4bedbc84b
https://doi.org/10.1006/jaut.1996.0020
https://doi.org/10.1006/jaut.1996.0020
Autor:
J Newcombe, David A. Hafler, Anja Windhagen, C Strand, M N Woodroofe, Fernando Dangond, M L Cuzner
Publikováno v:
The Journal of Experimental Medicine
Resting autoreactive T cells are present in the circulation of normal individuals without pathologic consequences. In autoimmune animal models, stimulation of these self-reactive T cells in the presence of costimulatory molecules B7-1 results in T ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a916f32de9bc051e787f0684f0801f2
http://europepmc.org/articles/PMC2192240
http://europepmc.org/articles/PMC2192240