Zobrazeno 1 - 10
of 21
pro vyhledávání: '"M L, Broccia"'
Publikováno v:
Reproductive Toxicology. 18:121-130
Fluconazole (FLUCO) and retinoic acid (RA) can perturb morphogenesis of the branchial apparatus in rodent embryos exposed in vitro. The aim of the present study was to compare the effects induced by in vitro exposure to FLUCO or to RA on rhombomere o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cd52a9081f6f0f086aa33e45faf19d6
https://doi.org/10.1016/j.reprotox.2003.09.004
https://doi.org/10.1016/j.reprotox.2003.09.004
Publikováno v:
Reproductive Toxicology. 15:421-427
Triazole-derivatives are antimycotics used in agriculture as well as in clinical and veterinary therapy. The aim of the present work is the in vitro comparative study of the teratogenic activity of triazole (the parental compound), flusilazole (an ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2df5c40e51bd4caad4b84138d5700c00
https://doi.org/10.1016/s0890-6238(01)00143-5
https://doi.org/10.1016/s0890-6238(01)00143-5
Publikováno v:
Teratology. 64:125-133
Background: The double staining of fetal skeleton for bone and cartilage is a very useful method to evidence skeletal abnormalities in laboratory animals. However, this method has been rarely used in routine developmental toxicity tests. One reason c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::333e82cd110566f8def9c2f3d684b89d
https://doi.org/10.1002/tera.1055
https://doi.org/10.1002/tera.1055
Publikováno v:
Toxicology in Vitro. 9:633-641
Previous in vitro studies demonstrated that acetaldehyde (ACHO) is able to produce specific morphological alterations related to the foetal alcohol syndrome. Intracellular reduced glutathione (GSH) has been shown to modulate the embryotoxicity elicit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f4fd252c132a5b738862d63970871f
https://doi.org/10.1016/0887-2333(95)00066-h
https://doi.org/10.1016/0887-2333(95)00066-h
Publikováno v:
Toxicology in Vitro. 7:777-784
Although the teratogenic potential of some glycol ethers and their active metabolites, the alkoxyacids, is well known, a comparative in vitro study of the embryotoxic potential of such compounds has not yet been conducted. The present study investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::188a97a8a90d6bcad0ca27aeb084c4c6
https://doi.org/10.1016/0887-2333(93)90081-f
https://doi.org/10.1016/0887-2333(93)90081-f
Publikováno v:
In Vitro Cellular & Developmental Biology - Animal. 28:205-210
Rat embryos were explanted on Days 9.5 or 10 of gestation and cultured for 48 to 30h, respectively, in rat serum containing 0, 3, 6, 9 mg/ml of Ethanol (Eth); 0, 10, 20 micrograms/ml of Acetaldehyde (Ach); 3 mg/ml Eth + 10 micrograms/ml Ach. At the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b53c23bb13913aff33c9d49e28bb48a
https://doi.org/10.1007/bf02631093
https://doi.org/10.1007/bf02631093
Autor:
Emanuela Corsini, F. Di Renzo, Marina Marinovich, Erminio Giavini, Corrado L. Galli, Elena Menegola, M. L. Broccia
Publikováno v:
Toxicology and applied pharmacology. 234(1)
Azole derivatives are teratogenic in rats and mice in vitro and in vivo. The postulated mechanism for the dysmorphogenetic effects is the inhibition of retinoic acid (RA)-degrading enzyme CYP26. Azole-related abnormalities are confined to structures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f323a7cd2eeb6fbc8dc0d31ef67a81
https://pubmed.ncbi.nlm.nih.gov/18976680
https://pubmed.ncbi.nlm.nih.gov/18976680
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 19(6)
Triazole-derivatives alter the pharyngeal apparatus morphogenesis of rodent embryos cultured in vitro. The hindbrain segmentation and the rhombencephalic neural crest cell (NCCs) migration are altered by Fluconazole exposure in vitro. The aim of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::980dc3bf319f7ae5070cfdff3834aa83
https://pubmed.ncbi.nlm.nih.gov/15913947
https://pubmed.ncbi.nlm.nih.gov/15913947
Publikováno v:
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
instname
instname
Experimental Doxorubicin-exposure in utero is correlated with foetal oesophageal atresia, tracheooesophageal fistula, axial alterations. While gastrointestinal and respiratory defects have been larg e l y investigated, only sporadic data have been pu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8cd46fe2e9500595aee2ddd404ffc952
http://hdl.handle.net/10201/20767
http://hdl.handle.net/10201/20767
Autor:
A, Mantovani, A V, Stazi, G, Bernardini, M L, Broccia, C, Nuccetelli, G, Pagano, L, Settimi, G M, Tiboni
Publikováno v:
Annali dell'Istituto superiore di sanita. 35(2)
Much knowledge concerning the effects of xenobiotics on prenatal development derive from experimental studies, which are generally performed on laboratory animals according to standardized protocols. Conventional in vivo studies should be integrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5e06c8e7937e969cf0437e8a89e24322
https://pubmed.ncbi.nlm.nih.gov/10645648
https://pubmed.ncbi.nlm.nih.gov/10645648