Výsledky vyhledávání - "M L, Appleton"

Identification of beta-glucuronidase-resistant diastereomeric glucuronides of 3-hydroxy-3-methyloxindole formed during 3-methylindole metabolism in goats

Autor: D J, Smith, M L, Appleton, J R, Carlson, G S, Yost

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 24(1)

Goats were jugularly infused with the pneumotoxin 3-methylindole (3MI; 15 mg/kg, 0.5 microCi/kg) dissolved in cremophor-EL to characterize the urinary metabolites of 3MI in a ruminant specie. Urine was collected for 36 hr after the beginning of a 2-h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a285998e1a282ab7be8b1ed06a0e822b
https://pubmed.ncbi.nlm.nih.gov/8825199

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Oxidation at C-1 controls the cytotoxicity of 1,1-dichloro-2,2- bis(p-chlorophenyl)ethane by rabbit and human lung cells

Autor: W K, Nichols, C M, Terry, N S, Cutler, M L, Appleton, P K, Jesthi, G S, Yost

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 23(5)

Isolated rabbit Clara cells and a transformed human bronchial epithelial cell line, BEAS-2B, were used to investigate the mechanism of cytotoxicity of 1,1-dichloro-2,2-bis(p-chlorophenyl)ethane (DDD), a persistent insecticide and stable metabolite of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f40b2873254b4a7aa0a12c789efedf00
https://pubmed.ncbi.nlm.nih.gov/7587937

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Toxicity of 3-methyleneoxindole, a proposed reactive intermediate in the metabolism of 3-methylindole

Autor: M L, Appleton, D N, Larson, G L, Skiles, W K, Nichols, G S, Yost

Publikováno v: Advances in experimental medicine and biology. 283

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7cd37498b182354bbd14df5f7c2e1b61
https://pubmed.ncbi.nlm.nih.gov/2068989

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