Výsledky vyhledávání - "M Kolomaznik"

Akademický článek

Pulmonary surfactant and prostaglandin E2 in airway smooth muscle relaxation of human and male guinea pigs

Autor: J. Hanusrichterova, M. Kolomaznik, R. Barosova, J. Adamcakova, D. Mokra, J. Mokry, H. Skovierova, M. M. Kelly, E. deHeuvel, S. Wiehler, D. Proud, H. Shen, P. G. Mukherjee, M. W. Amrein, A. Calkovska

Publikováno v: Physiological Reports, Vol 12, Iss 17, Pp n/a-n/a (2024)

Abstract Pulmonary surfactant serves as a barrier to respiratory epithelium but can also regulate airway smooth muscle (ASM) tone. Surfactant (SF) relaxes contracted ASM, similar to β2‐agonists, anticholinergics, nitric oxide, and prostanoids. The

Externí odkaz: https://doaj.org/article/b61fa7c8da2044a69945f7d1fe1fe882

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Efficacy of Surfactant Therapy of ARDS Induced by Hydrochloric Acid Aspiration Followed by Ventilator-Induced Lung Injury – an Animal Study

Autor: P MIKOLKA, P KOSUTOVA, M KOLOMAZNIK, S MATEFFY, N NEMCOVA, D MOKRA, A CALKOVSKA

Publikováno v: Physiol Res

The development of acute respiratory distress syndrome (ARDS) is known to be independently attributable to aspiration-induced lung injury. Mechanical ventilation as a high pressure/volume support to maintain sufficient oxygenation of a patient could

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12f6e9323e4af3f2def35105c3de932e
https://europepmc.org/articles/PMC9906666/

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Akademický článek

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Early Cardiac Injury in Acute Respiratory Distress Syndrome: Comparison of Two Experimental Models

Autor: Daniel Čierny, Pavol Mikolka, P Kosutova, J Kopincova, Andrea Calkovska, Marian Adamkov, Daniela Mokra, M Kolomaznik, Sona Balentova

Publikováno v: Physiol Res

Acute respiratory distress syndrome (ARDS) is characterized by diffuse lung damage, inflammation, oedema formation, and surfactant dysfunction leading to hypoxemia. Severe ARDS can accelerate the injury of other organs, worsening the patient´s statu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fae71c1fdd69785bdde4690dca5e425f
https://doi.org/10.33549/physiolres.934591

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Alveolar type II cells and pulmonary surfactant in COVID-19 era

Autor: A CALKOVSKA, M KOLOMAZNIK, V CALKOVSKY

Publikováno v: Physiol Res

In this review, we discuss the role of pulmonary surfactant in the host defense against respiratory pathogens, including novel coronavirus SARS-CoV-2. In the lower respiratory system, the virus uses angiotensin-converting enzyme 2 (ACE2) receptor in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a455abd29d7d789764c3c8468eba6d72
https://pubmed.ncbi.nlm.nih.gov/34913352

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Akademický článek

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Effect of Different Dosages of Dexamethasone Therapy on Lung Function and Inflammation in an Early Phase of Acute Respiratory Distress Syndrome Model

Autor: M Kolomaznik, P Kosutova, Daniela Mokra, J Kopincova, Pavol Mikolka, Juliana Topercerova, Andrea Calkovska

Publikováno v: Physiological Research. :S253-S263

Inflammation associated with acute respiratory distress syndrome (ARDS) can damage the alveolar epithelium and surfactant and worsen the respiratory failure. Glucocorticoids (GC) appear to be a rational therapeutic approach, but the effect is still u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b6dbb84a11276588b8a2735fb4dba1c
https://doi.org/10.33549/physiolres.934364

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The Effect of Modified Porcine Surfactant Alone or in Combination with Polymyxin B on Lung Homeostasis in LPS-Challenged and Mechanically Ventilated Adult Rats

Autor: Zuzana Nová, Pavol Mikolka, Juliana Topercerova, Andrea Calkovska, Henrieta Škovierová, J Kopincova, Katarina Matasova, M Kolomaznik, Daniela Mokra, I. Zila, Marian Grendar, P Kosutova

Publikováno v: Molecules
Volume 25
Issue 19
Molecules, Vol 25, Iss 4356, p 4356 (2020)

The study aimed to prove the hypothesis that exogenous surfactant and an antibiotic polymyxin B (PxB) can more effectively reduce lipopolysaccharide (LPS)-induced acute lung injury (ALI) than surfactant treatment alone, and to evaluate the effect of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4811a7389ea8b61d4977a7e487c1a7e
http://europepmc.org/articles/PMC7582504

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The effect of pulmonary surfactant on the airway smooth muscle after lipopolysaccharide exposure and its mechanisms

Autor: Zuzana Nová, Juliana Topercerova, Anna Urbanova, Andrea Calkovska, J Kopincova, Juraj Mokry, Daniela Mokra, M Kolomaznik

Publikováno v: Physiological research. 68(Suppl 3)

Pulmonary surfactant has a relaxing effect on the airway smooth muscle (ASM), which suggests its role in the pathogenesis of respiratory diseases associated with hyperreactivity of the ASM, such as asthma and chronic obstructive pulmonary disease (CO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66befa1e0e7a0b142d16f758ac778e55
https://pubmed.ncbi.nlm.nih.gov/31928045

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Reduction of Lung Inflammation, Oxidative Stress and Apoptosis by the PDE4 Inhibitor Roflumilast in Experimental Model of Acute Lung Injury

Autor: P Kosutova, Daniela Mokra, Andrea Calkovska, M Kolomaznik, Soňa Bálentová, Marian Adamkov, Pavol Mikolka

Publikováno v: Physiological Research. :S645-S654

Damage of alveolar-capillary barrier, inflammation, oxidative injury, and lung cell apoptosis represent the key features of acute lung injury (ALI). This study evaluated if selective phosphodiesterase (PDE)-4 inhibitor roflumilast can reduce the ment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84ddbe58b7101ce37d1140ef21acc5df
https://doi.org/10.33549/physiolres.934047

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