Zobrazeno 1 - 10
of 2 171
pro vyhledávání: '"M Kohli"'
Autor:
Yee Hoon Foong, Blake Caldwell, Joanne L. Thorvaldsen, Christopher Krapp, Clementina A. Mesaros, Wanding Zhou, Rahul M. Kohli, Marisa S. Bartolomei
Publikováno v:
Epigenetics, Vol 19, Iss 1 (2024)
TET1/2/3 dioxygenases iteratively demethylate 5-methylcytosine, beginning with the formation of 5-hydroxymethylcytosine (5hmC). The post-mitotic brain maintains higher levels of 5hmC than most peripheral tissues, and TET1 ablation studies have unders
Externí odkaz:
https://doaj.org/article/15da1f095f5e460fb87e5885ecd73cc9
Autor:
Hugo C. Medina-Munoz, Eric Kofman, Pratibha Jagannatha, Evan A. Boyle, Tao Yu, Krysten L. Jones, Jasmine R. Mueller, Grace D. Lykins, Andrew T. Doudna, Samuel S. Park, Steven M. Blue, Brodie L. Ranzau, Rahul M. Kohli, Alexis C. Komor, Gene W. Yeo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract RNA binding proteins (RBPs) are key regulators of RNA processing and cellular function. Technologies to discover RNA targets of RBPs such as TRIBE (targets of RNA binding proteins identified by editing) and STAMP (surveying targets by APOBEC
Externí odkaz:
https://doaj.org/article/8d2fba859be64189bf8bdb600ad90c27
Autor:
Iris K. Lee, Daniel A. Jacome, Joshua K. Cho, Vincent Tu, Anthony J. Young, Tiffany Dominguez, Justin D. Northrup, Jean M. Etersque, Hsiaoju S. Lee, Andrew Ruff, Ouniol Aklilu, Kyle Bittinger, Laurel J. Glaser, Daniel Dorgan, Denis Hadjiliadis, Rahul M. Kohli, Robert H. Mach, David A. Mankoff, Robert K. Doot, Mark A. Sellmyer
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 18 (2023)
BACKGROUND Several molecular imaging strategies can identify bacterial infections in humans. PET affords the potential for sensitive infection detection deep within the body. Among PET-based approaches, antibiotic-based radiotracers, which often targ
Externí odkaz:
https://doaj.org/article/30dd4ba430cb4828857bbc391f587035
Autor:
S. Sadoo, R. Nalugya, R. Lassman, M. Kohli-Lynch, G. Chariot, H. G. Davies, E. Katuutu, M. Clee, J. Seeley, E. L. Webb, R. Mutoni Vedastine, F. Beckerlegge, C. J. Tann
Publikováno v:
BMC Pediatrics, Vol 22, Iss 1, Pp 1-14 (2022)
Abstract Background Early support for children with developmental disabilities is crucial but frequently unavailable in low-resource settings. We conducted a mixed-methods evaluation to assess the feasibility, acceptability, and impact of a programme
Externí odkaz:
https://doaj.org/article/ca6c2a36498b410593fb2e49d49428fe
Publikováno v:
Indian Journal of Ophthalmology, Vol 70, Iss 7, Pp 2498-2504 (2022)
Purpose: To analyze the anatomical and visual outcomes of microincision vitrectomy surgery (MIVS) with silicone oil tamponade in eyes having coloboma-related retinal detachment (RD) and evaluate the risk factors for recurrence of RD. Methods: This wa
Externí odkaz:
https://doaj.org/article/a73e2a73e3b3447d8aa7f0c5e140afc7
Publikováno v:
Molecular Metabolism, Vol 57, Iss , Pp 101314- (2022)
Background: In mammals, modifications to cytosine bases, particularly in cytosine-guanine (CpG) dinucleotide contexts, play a major role in shaping the epigenome. The canonical epigenetic mark is 5-methylcytosine (5mC), but oxidized versions of 5mC,
Externí odkaz:
https://doaj.org/article/12c6b9eaa171460caf362a365d6fa3e4
Publikováno v:
Indian Journal of Ophthalmology, Vol 70, Iss 12, Pp 4468-4469 (2022)
Externí odkaz:
https://doaj.org/article/81fd4b49940d42c6b8cea4abb0fd1758
Autor:
Rodrigo A. Gier, Krista A. Budinich, Niklaus H. Evitt, Zhendong Cao, Elizabeth S. Freilich, Qingzhou Chen, Jun Qi, Yemin Lan, Rahul M. Kohli, Junwei Shi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Reliable, multiplexed gene editing to uncover synergies between targets remains challenging. Here, the authors engineer AsCas12a and the crRNA to improve double knockout for synthetic sick/lethal interaction genetic screening.
Externí odkaz:
https://doaj.org/article/200dde47acd44d708c32a6bcf129cbd0
Publikováno v:
Indian Journal of Ophthalmology, Vol 68, Iss 1, Pp 91-98 (2020)
Purpose: To report the outcomes of pars-plana approach for the management of brunescent cataract in eyes with severe microcornea and associated chorio-retinal coloboma. Methods: This was a retrospective, single center, interventional case series perf
Externí odkaz:
https://doaj.org/article/0ac55e2bdae84684a2366418d43e179f
Publikováno v:
Indian Journal of Ophthalmology, Vol 68, Iss 6, Pp 1193-1196 (2020)
We present a case of persistent macular hole (MH) having an apical diameter of 140 microns and a basal diameter of 530 microns following a combined phacoemulsification and MH surgery. Considering post-operative cystoid macular edema (CME) as the poss
Externí odkaz:
https://doaj.org/article/e4bf77ffe14f4e1c8fc82128c128a46c