Zobrazeno 1 - 10
of 981
pro vyhledávání: '"M Kirkpatrick"'
Autor:
Aleksandar Bartolome, Julia C Heiby, Domenico Di Fraia, Ivonne Heinze, Hannah Knaudt, Ellen Spaeth, Omid Omrani, Alberto Minetti, Maleen Hofmann, Joanna M Kirkpatrick, Therese Dau, Alessandro Ori
Publikováno v:
eLife, Vol 13 (2024)
Proteasomes are essential molecular machines responsible for the degradation of proteins in eukaryotic cells. Altered proteasome activity has been linked to neurodegeneration, auto-immune disorders and cancer. Despite the relevance for human disease
Externí odkaz:
https://doaj.org/article/eb11939432d947b9a7853c59ac4621e3
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Sightings of unidentified flying objects (UFOs) or unidentified anomalous phenomena (UAP) have been reported throughout history. Given the potential security and safety risks they pose, as well as scientific curiosity, there is increasing in
Externí odkaz:
https://doaj.org/article/35b2b566d73240e9928509834240b34f
Autor:
Nuria Tubío-Santamaría, Ashok Kumar Jayavelu, Tina M. Schnoeder, Theresa Eifert, Chen-Jen Hsu, Florian Perner, Qirui Zhang, Daniela V. Wenge, Fynn M. Hansen, Joanna M. Kirkpatrick, Nidhi Jyotsana, Steven W. Lane, Björn von Eyss, Aniruddha J. Deshpande, Michael W. M. Kühn, Juerg Schwaller, Clemens Cammann, Ulrike Seifert, Frédéric Ebstein, Elke Krüger, Andreas Hochhaus, Michael Heuser, Alessandro Ori, Matthias Mann, Scott A. Armstrong, Florian H. Heidel
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-21 (2023)
Abstract Pharmacologic targeting of chromatin-associated protein complexes has shown significant responses in KMT2A-rearranged (KMT2A-r) acute myeloid leukemia (AML) but resistance frequently develops to single agents. This points to a need for thera
Externí odkaz:
https://doaj.org/article/32a44bd3490c43d78d23fc64b13aaac5
Autor:
Kaitlin E. Bountress, Shannon E. Cusack, Sage E. Hawn, Andrew Grotzinger, Daniel Bustamante, Robert M. Kirkpatrick, Howard J. Edenberg, Ananda B. Amstadter
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Alcohol use (i.e., quantity, frequency) and alcohol use disorder (AUD) are common, associated with adverse outcomes, and genetically-influenced. Genome-wide association studies (GWAS) identified genetic loci associated with both. AUD is posi
Externí odkaz:
https://doaj.org/article/35657d9ed7924f69b8d432f0ce6e8795
Autor:
Dario Lucas Helbing, Joanna M. Kirkpatrick, Michael Reuter, Julia Bischoff, Amy Stockdale, Annemarie Carlstedt, Emilio Cirri, Reinhard Bauer, Helen Morrison
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Aging of the peripheral nervous system (PNS) is associated with structural and functional changes that lead to a reduction in regenerative capacity and the development of age-related peripheral neuropathy. Myelin is central to maintaining physiologic
Externí odkaz:
https://doaj.org/article/95ec0a759be34c7dbea740698ed0ee90
Autor:
Katie M Kirkpatrick, Carolyn A Kleinberger, Elizabeth M Moylan, Asma S Bukhari, Patricia A Deuster
Publikováno v:
Public Health Nutrition, Vol 26, Pp 219-228 (2023)
Abstract Objective: The aim was to develop, refine and assess the usefulness of the Go for Green® (G4G) 2.0 Program Fidelity Assessment (PFA) tool. G4G 2.0 is a Department of Defense programme designed to optimise access, availability and knowledge
Externí odkaz:
https://doaj.org/article/a1678c05bbf543ef809354af39e13a99
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Introduction: The availability of large-scale biobanks linking genetic data, rich phenotypes, and biological measures is a powerful opportunity for scientific discovery. However, real-world collections frequently have extensive missingness. While mis
Externí odkaz:
https://doaj.org/article/0ef8771c255848978b6a66282608f123
Publikováno v:
Pharmacy, Vol 11, Iss 6, p 188 (2023)
The Australian Federal Government’s Community Pharmacy Agreement (Agreement), initiated in 1990 and renegotiated every five years with a pharmacy owners’ organisation, is the dominant policy directing community pharmacy. We studied the experience
Externí odkaz:
https://doaj.org/article/7ec6792bfe4c4224a9ebf65c1d5a2e03
Autor:
Simone Di Sanzo, Katrin Spengler, Anja Leheis, Joanna M. Kirkpatrick, Theresa L. Rändler, Tim Baldensperger, Therese Dau, Christian Henning, Luca Parca, Christian Marx, Zhao-Qi Wang, Marcus A. Glomb, Alessandro Ori, Regine Heller
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Accumulation of advanced glycation end products such as carboxymethyllysine (CML) has been associated with aging but their molecular roles are largely unclear. Here, the authors use proteomics to identify CML sites and show that CML formation affects
Externí odkaz:
https://doaj.org/article/2a95d56d607f461daa73332371e24e27
Autor:
Elys A. Green, David Metz, Robert Galinsky, Rebecka Atkinson, Elizbeth M. Skuza, Megan Clark, Alistair J Gunn, Carl M. Kirkpatrick, Rod W. Hunt, Philip J. Berger, Claudia A. Nold-Petry, Marcel F. Nold
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundBronchopulmonary dysplasia (BPD), its complication pulmonary hypertension (BPD-PH) and preterm brain and gut injury lead to significant morbidity and mortality in infants born extremely prematurely. There is extensive evidence that the pro-
Externí odkaz:
https://doaj.org/article/c0f4af5669eb4694b88b441bdbe5d12d