Zobrazeno 1 - 10
of 148
pro vyhledávání: '"M Kedziora"'
Autor:
Sayan Ghosh, Ruchi Sharma, Sridhar Bammidi, Victoria Koontz, Mihir Nemani, Meysam Yazdankhah, Katarzyna M. Kedziora, Donna Beer Stolz, Callen T. Wallace, Cheng Yu-Wei, Jonathan Franks, Devika Bose, Peng Shang, Helena M. Ambrosino, James R. Dutton, Zhaohui Geng, Jair Montford, Jiwon Ryu, Dhivyaa Rajasundaram, Stacey Hose, José-Alain Sahel, Rosa Puertollano, Toren Finkel, J. Samuel Zigler, Yuri Sergeev, Simon C. Watkins, Eric S. Goetzman, Deborah A. Ferrington, Miguel Flores-Bellver, Kai Kaarniranta, Akrit Sodhi, Kapil Bharti, James T. Handa, Debasish Sinha
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Non-neovascular or dry age-related macular degeneration (AMD) is a multi-factorial disease with degeneration of the aging retinal-pigmented epithelium (RPE). Lysosomes play a crucial role in RPE health via phagocytosis and autophagy, which a
Externí odkaz:
https://doaj.org/article/9a768d2563fb4e4f839cd5a860fabad3
Autor:
Michael J. Cotton, Pablo Ariel, Kaiwen Chen, Vanessa A. Walcott, Michelle Dixit, Keith A. Breau, Caroline M. Hinesley, Katarzyna M. Kedziora, Cynthia Y. Tang, Anna Zheng, Scott T. Magness, Joseph Burclaff
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract The intestinal epithelium dynamically controls cell cycle, yet no experimental platform exists for directly analyzing cell cycle phases in non-immortalized human intestinal epithelial cells (IECs). Here, we present two reporters and a comple
Externí odkaz:
https://doaj.org/article/2166ab0898f7409294e33d7ee9771520
Autor:
Wayne Stallaert, Sovanny R Taylor, Katarzyna M Kedziora, Colin D Taylor, Holly K Sobon, Catherine L Young, Juanita C Limas, Jonah Varblow Holloway, Martha S Johnson, Jeanette Gowen Cook, Jeremy E Purvis
Publikováno v:
Molecular Systems Biology, Vol 18, Iss 9, Pp 1-14 (2022)
Abstract The cellular decision governing the transition between proliferative and arrested states is crucial to the development and function of every tissue. While the molecular mechanisms that regulate the proliferative cell cycle are well establish
Externí odkaz:
https://doaj.org/article/cbb51f9db4bc4754b922f26991fa63c9
AGS3 antagonizes LGN to balance oriented cell divisions and cell fate choices in mammalian epidermis
Autor:
Carlos P Descovich, Kendall J Lough, Akankshya Jena, Jessica J Wu, Jina Yom, Danielle C Spitzer, Manuela Uppalapati, Katarzyna M Kedziora, Scott E Williams
Publikováno v:
eLife, Vol 12 (2023)
Oriented cell divisions balance self-renewal and differentiation in stratified epithelia such as the skin epidermis. During peak epidermal stratification, the distribution of division angles among basal keratinocyte progenitors is bimodal, with plana
Externí odkaz:
https://doaj.org/article/a0bb50460c8e4723a4d8a41ba4e782f4
Autor:
Ashelyn E Sidders, Katarzyna M Kedziora, Melina Arts, Jan-Martin Daniel, Stefania de Benedetti, Jenna E Beam, Duyen T Bui, Joshua B Parsons, Tanja Schneider, Sarah E Rowe, Brian P Conlon
Publikováno v:
eLife, Vol 12 (2023)
Antibiotic tolerance and antibiotic resistance are the two major obstacles to the efficient and reliable treatment of bacterial infections. Identifying antibiotic adjuvants that sensitize resistant and tolerant bacteria to antibiotic killing may lead
Externí odkaz:
https://doaj.org/article/6b73aca696fd4a22bd95efcb07639f3f
Autor:
Phillip G. Durham, Ashelyn E. Sidders, Jenna E. Beam, Katarzyna M. Kedziora, Paul A. Dayton, Brian P. Conlon, Virginie Papadopoulou, Sarah E. Rowe
Publikováno v:
Biofilm, Vol 3, Iss , Pp 100049- (2021)
Bacterial biofilms, often associated with chronic infections, respond poorly to antibiotic therapy and frequently require surgical intervention. Biofilms harbor persister cells, metabolically indolent cells, which are tolerant to most conventional an
Externí odkaz:
https://doaj.org/article/ed9cc9a73dc4482bb59e56b77037462b
Autor:
Hui Xiao Chao, Randy I Fakhreddin, Hristo K Shimerov, Katarzyna M Kedziora, Rashmi J Kumar, Joanna Perez, Juanita C Limas, Gavin D Grant, Jeanette Gowen Cook, Gaorav P Gupta, Jeremy E Purvis
Publikováno v:
Molecular Systems Biology, Vol 15, Iss 3, Pp 1-19 (2019)
Abstract The cell cycle is canonically described as a series of four consecutive phases: G1, S, G2, and M. In single cells, the duration of each phase varies, but the quantitative laws that govern phase durations are not well understood. Using time
Externí odkaz:
https://doaj.org/article/81290e9fcfee4492b0f34caf81dfef6d
Autor:
Samuel C Wolff, Katarzyna M Kedziora, Raluca Dumitru, Cierra D Dungee, Tarek M Zikry, Adriana S Beltran, Rachel A Haggerty, JrGang Cheng, Margaret A Redick, Jeremy E Purvis
Publikováno v:
Molecular Systems Biology, Vol 14, Iss 9, Pp 1-9 (2018)
Abstract It is well known that clonal cells can make different fate decisions, but it is unclear whether these decisions are determined during, or before, a cell's own lifetime. Here, we engineered an endogenous fluorescent reporter for the pluripote
Externí odkaz:
https://doaj.org/article/ce877a86d66346a5a7021a2bb8a4c608
Publikováno v:
Die Kardiologie. 16:466-478
Zusammenfassung Hintergrund Aufgrund der neuen Leitlinien der European Society of Cardiology (ESC) zur Diagnostik und Behandlung der akuten und chronischen Herzinsuffizienz (McDonagh et al. 2021) kann Vericiguat (Verquvo®) zur Behandlung von erwachs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a2677dd90885458b5ec68d0322debe6
https://doi.org/10.1007/s12181-022-00576-y
https://doi.org/10.1007/s12181-022-00576-y
Autor:
Kathryn M. Headley, Katarzyna M. Kedziora, Aidin Alejo, Elianna Zhi-Xiang Lai, Jeremy E. Purvis, Nathaniel A. Hathaway
Publikováno v:
Stem Cell Research, Vol 38, Iss , Pp - (2019)
Here we utilized the chromatin in vivo assay (CiA) mouse platform to directly examine the epigenetic barriers impeding the activation of the CiA:Oct4 allele in mouse embryonic fibroblasts (MEF)s when stimulated with a transcription factor. The CiA:Oc
Externí odkaz:
https://doaj.org/article/32351aaaf3894319a827aa5bbfe3b5ad