Zobrazeno 1 - 10
of 472
pro vyhledávání: '"M Karst"'
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT As the largest mucosal surface, the gastrointestinal (GI) tract plays a key role in protecting the host against pathogen infections. It is a first line of defense against enteric viruses and must act to control infection while remaining tole
Externí odkaz:
https://doaj.org/article/205bcc074f614bf2aedfb97fc5dd4c0c
Autor:
Thomas Y. Michaelsen, Marc Bennedbæk, Lasse E. Christiansen, Mia S. F. Jørgensen, Camilla H. Møller, Emil A. Sørensen, Simon Knutsson, Jakob Brandt, Thomas B. N. Jensen, Clarisse Chiche-Lapierre, Emilio F. Collados, Trine Sørensen, Celine Petersen, Vang Le-Quy, Mantas Sereika, Frederik T. Hansen, Morten Rasmussen, Jannik Fonager, Søren M. Karst, Rasmus L. Marvig, Marc Stegger, Raphael N. Sieber, Robert Skov, Rebecca Legarth, Tyra G. Krause, Anders Fomsgaard, The Danish COVID-19 Genome Consortium (DCGC), Mads Albertsen
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-13 (2022)
Abstract Background In early 2021, the SARS-CoV-2 lineage B.1.1.7 (Alpha variant) became dominant across large parts of the world. In Denmark, comprehensive and real-time test, contact-tracing, and sequencing efforts were applied to sustain epidemic
Externí odkaz:
https://doaj.org/article/0126e49679474a8297be703426b5ac4f
Autor:
Marco Grodzki, Andrew P. Bluhm, Moritz Schaefer, Abderrahmane Tagmount, Max Russo, Amin Sobh, Roya Rafiee, Chris D. Vulpe, Stephanie M. Karst, Michael H. Norris
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-18 (2022)
Abstract Background The COVID-19 pandemic has resulted in 275 million infections and 5.4 million deaths as of December 2021. While effective vaccines are being administered globally, there is still a great need for antiviral therapies as antigenicall
Externí odkaz:
https://doaj.org/article/0389603ba2a943b3a03f0bb2d378231d
Autor:
Katja Spiess, Vithiagaran Gunalan, Ellinor Marving, Sofie Holdflod Nielsen, Michelle G. P. Jørgensen, Anna S. Fomsgaard, Line Nielsen, Alonzo Alfaro-Núñez, Søren M. Karst, Shila Mortensen, Morten Rasmussen, Ria Lassaunière, Maiken Worsøe Rosenstierne, Charlotta Polacek, Jannik Fonager, Arieh S. Cohen, Claus Nielsen, Anders Fomsgaard
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 1 (2023)
ABSTRACT Multiple mutations in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) increase transmission, disease severity, and immune evasion and facilitate zoonotic or anthropozoonotic infections. Four such mutat
Externí odkaz:
https://doaj.org/article/dd8fc4256706407c99f17cdfe3a4d51f
Autor:
Emily W. Helm, Amy M. Peiper, Matthew Phillips, Caroline G. Williams, Michael B. Sherman, Theresa Kelley, Hong Q. Smith, Sorin O. Jacobs, Dhairya Shah, Sarah M. Tatum, Neha Iyer, Marco Grodzki, Joyce C. Morales Aparicio, Elizabeth A. Kennedy, Mikayla S. Manzi, Megan T. Baldridge, Thomas J. Smith, Stephanie M. Karst
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Noroviruses are the leading cause of severe childhood diarrhea and foodborne disease worldwide. While they are a major cause of disease in all age groups, infections in the very young can be quite severe with annual estimates of 50,000-200,000 fatali
Externí odkaz:
https://doaj.org/article/977826bdb7f747619d7e66707745bdfc
Autor:
Caitlin M. Singleton, Francesca Petriglieri, Jannie M. Kristensen, Rasmus H. Kirkegaard, Thomas Y. Michaelsen, Martin H. Andersen, Zivile Kondrotaite, Søren M. Karst, Morten S. Dueholm, Per H. Nielsen, Mads Albertsen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Microbes play key roles in wastewater treatment. Here, Singleton et al. use long-read and short-read sequencing to recover 1083 high-quality metagenome-assembled genomes from 23 wastewater treatment plants, and combine this information with amplicon
Externí odkaz:
https://doaj.org/article/d093b63b2bc34d1cba80ef3ca3aff026
Autor:
Carmen Mirabelli, Melissa K. Jones, Vivienne L. Young, Abimbola O. Kolawole, Irene Owusu, Mengrou Shan, Basel Abuaita, Holly Turula, Jose G. Trevino, Irina Grigorova, Steven K. Lundy, Costas A. Lyssiotis, Vernon K. Ward, Stephanie M. Karst, Christiane E. Wobus
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT Human norovirus (HNoV) is a global health and socioeconomic burden, estimated to infect every individual at least five times during their lifetime. The underlying mechanism for the potential lack of long-term immune protection from HNoV infe
Externí odkaz:
https://doaj.org/article/298a2a3779044a91988f0db58af882d8
Autor:
Alexa N. Roth, Emily W. Helm, Carmen Mirabelli, Erin Kirsche, Jonathan C. Smith, Laura B. Eurell, Sourish Ghosh, Nihal Altan-Bonnet, Christiane E. Wobus, Stephanie M. Karst
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Here the authors show that a murine norovirus causes self-resolving diarrhea in the absence of systemic disease in wild-type neonatal mice and show that lymphocytes affect disease in a dual manner. The data suggests that neonatal mice are a promising
Externí odkaz:
https://doaj.org/article/9a6932ec89e94268872ca25929c2bda7
Autor:
J. Schiller, T. Kellner, J. Briest, K. Hoepner, A. Woyciechowski, A. Ostermann, C. Korallus, C. Sturm, T. Weiberlenn, L. Jiang, C. Egen, F. Beissner, M. Stiesch, M. Karst, C. Gutenbrunner, M. G. Fink
Publikováno v:
Trials, Vol 20, Iss 1, Pp 1-11 (2019)
Abstract Background This study aims to evaluate the feasibility and efficacy of a complex health intervention, based on the combination of conventional Western medicine and traditional Chinese medicine (TCM), in an outpatient department of a universi
Externí odkaz:
https://doaj.org/article/1db52af834cc43e5bf0c577cee893b48
Autor:
Forrest C Walker, Ebrahim Hassan, Stefan T Peterson, Rachel Rodgers, Lawrence A Schriefer, Cassandra E Thompson, Yuhao Li, Gowri Kalugotla, Carla Blum-Johnston, Dylan Lawrence, Broc T McCune, Vincent R Graziano, Larissa Lushniak, Sanghyun Lee, Alexa N Roth, Stephanie M Karst, Timothy J Nice, Jonathan J Miner, Craig B Wilen, Megan T Baldridge
Publikováno v:
PLoS Pathogens, Vol 17, Iss 3, p e1009402 (2021)
Interferons (IFNs) are key controllers of viral replication, with intact IFN responses suppressing virus growth and spread. Using the murine norovirus (MNoV) system, we show that IFNs exert selective pressure to limit the pathogenic evolutionary pote
Externí odkaz:
https://doaj.org/article/90fb07bf8a2e40fb883cfc49c1867b66