Basement membrane collagen IV deficiency promotes abdominal aortic aneurysm formation

Autor: M L T Tha, Jes S. Lindholt, Matthew J. Bown, Maria Bloksgaard, Lars Melholt Rasmussen, Federica Genovese, Lasse Bach Steffensen, S Holm Nielsen, M.A. Karsdal, J H Larsen, Martin Overgaard, D R Hansen, Jane Stubbe, S K Bang-Moeller, Hans Christian Beck, M K T Hong Lin, Gregory T. Jones

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Steffensen, L B, Stubbe, J, Lindholt, J S, Beck, H C, Overgaard, M, Bloksgaard, M, Genovese, F, Holm Nielsen, S, Tha, M L T, Bang-Moeller, S K, Hong Lin, M K T, Larsen, J H, Hansen, D R, Jones, G T, Bown, M J, Karsdal, M A & Rasmussen, L M 2021, ' Basement membrane collagen IV deficiency promotes abdominal aortic aneurysm formation ', Scientific Reports, vol. 11, 12903 . https://doi.org/10.1038/s41598-021-92303-y
Steffensen, L B, Stubbe, J, Lindholt, J S, Beck, H C, Overgaard, M, Bloksgaard, M, Genovese, F, Holm Nielsen, S, Tha, M L T, Bang-Moeller, S K, Hong Lin, M K T, Larsen, J H, Hansen, D R, Jones, G T, Bown, M J, Karsdal, M A & Rasmussen, L M 2021, ' Basement membrane collagen IV deficiency promotes abdominal aortic aneurysm formation ', Scientific Reports, vol. 11, no. 1, 12903 . https://doi.org/10.1038/s41598-021-92303-y
Scientific Reports

Abdominal aortic aneurysm (AAA) is a complex disease which is incompletely accounted for. Basement membrane (BM) Collagen IV (COL4A1/A2) is abundant in the artery wall, and several lines of evidence indicate a protective role of baseline COL4A1/A2 in

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https://doaj.org/article/3d1b5c247947475dacbe108ba6ec5da2