Zobrazeno 1 - 10
of 50
pro vyhledávání: '"M K Raghuraman"'
Autor:
Rebecca Martin, Claudia Y Espinoza, Christopher R L Large, Joshua Rosswork, Cole Van Bruinisse, Aaron W Miller, Joseph C Sanchez, Madison Miller, Samantha Paskvan, Gina M Alvino, Maitreya J Dunham, M K Raghuraman, Bonita J Brewer
Publikováno v:
PLoS Genetics, Vol 20, Iss 1, p e1010850 (2024)
Inherited and germ-line de novo copy number variants (CNVs) are increasingly found to be correlated with human developmental and cancerous phenotypes. Several models for template switching during replication have been proposed to explain the generati
Externí odkaz:
https://doaj.org/article/ca42be6fe50841a6a5966a175c1f7179
Publikováno v:
PLoS Genetics, Vol 20, Iss 1, p e1011091 (2024)
With the release of the telomere-to-telomere human genome sequence and the availability of both long-read sequencing and optical genome mapping techniques, the identification of copy number variants (CNVs) and other structural variants is providing n
Externí odkaz:
https://doaj.org/article/f4ac5e5b8cc9472c8d2bc8fb7d6b64fa
Publikováno v:
PLoS Genetics, Vol 15, Iss 10, p e1008430 (2019)
Chromosome replication in Saccharomyces cerevisiae is initiated from ~300 origins that are regulated by DNA sequence and by the limited abundance of six trans-acting initiation proteins (Sld2, Sld3, Dpb11, Dbf4, Sld7 and Cdc45). We set out to determi
Externí odkaz:
https://doaj.org/article/15671315f5cb4c279832ff5d239e0ecb
Autor:
Joseph C Sanchez, Elizabeth X Kwan, Thomas J Pohl, Haley M Amemiya, M K Raghuraman, Bonita J Brewer
Publikováno v:
PLoS Genetics, Vol 13, Iss 10, p e1007041 (2017)
A form of dwarfism known as Meier-Gorlin syndrome (MGS) is caused by recessive mutations in one of six different genes (ORC1, ORC4, ORC6, CDC6, CDT1, and MCM5). These genes encode components of the pre-replication complex, which assembles at origins
Externí odkaz:
https://doaj.org/article/c428286c82bd4029ae1c65b1892d6f21
Autor:
Bonita J Brewer, Celia Payen, Sara C Di Rienzi, Megan M Higgins, Giang Ong, Maitreya J Dunham, M K Raghuraman
Publikováno v:
PLoS Genetics, Vol 11, Iss 12, p e1005699 (2015)
DNA replication errors are a major driver of evolution--from single nucleotide polymorphisms to large-scale copy number variations (CNVs). Here we test a specific replication-based model to explain the generation of interstitial, inverted triplicatio
Externí odkaz:
https://doaj.org/article/c31b5a7f3f8b49608fa44c43471b7a27
GC-rich DNA elements enable replication origin activity in the methylotrophic yeast Pichia pastoris.
Autor:
Ivan Liachko, Rachel A Youngblood, Kyle Tsui, Kerry L Bubb, Christine Queitsch, M K Raghuraman, Corey Nislow, Bonita J Brewer, Maitreya J Dunham
Publikováno v:
PLoS Genetics, Vol 10, Iss 3, p e1004169 (2014)
The well-studied DNA replication origins of the model budding and fission yeasts are A/T-rich elements. However, unlike their yeast counterparts, both plant and metazoan origins are G/C-rich and are associated with transcription start sites. Here we
Externí odkaz:
https://doaj.org/article/58e66a41b5c84c4daf1e96c63c2620b9
Autor:
Elizabeth X Kwan, Eric J Foss, Scott Tsuchiyama, Gina M Alvino, Leonid Kruglyak, Matt Kaeberlein, M K Raghuraman, Bonita J Brewer, Brian K Kennedy, Antonio Bedalov
Publikováno v:
PLoS Genetics, Vol 9, Iss 3, p e1003329 (2013)
Aging and longevity are complex traits influenced by genetic and environmental factors. To identify quantitative trait loci (QTLs) that control replicative lifespan, we employed an outbred Saccharomyces cerevisiae model, generated by crossing a viney
Externí odkaz:
https://doaj.org/article/356236c712c8426c8604962fc9490be9
Publikováno v:
PLoS Genetics, Vol 8, Iss 5, p e1002677 (2012)
The centromeric regions of all Saccharomyces cerevisiae chromosomes are found in early replicating domains, a property conserved among centromeres in fungi and some higher eukaryotes. Surprisingly, little is known about the biological significance or
Externí odkaz:
https://doaj.org/article/3756547bed994ea58590eb145d5b825d
Publikováno v:
PLoS Genetics, Vol 7, Iss 3, p e1002016 (2011)
Externí odkaz:
https://doaj.org/article/9ddd6de4a9054b1e8821cdd6257304c3
Autor:
Remington E Hoerr, Alex Eng, Celia Payen, Sara C Di Rienzi, M K Raghuraman, Maitreya J Dunham, Bonita J Brewer, Katherine L Friedman
Publikováno v:
GENETICS. 224
Evolution is driven by the accumulation of competing mutations that influence survival. A broad form of genetic variation is the amplification or deletion of DNA (≥50 bp) referred to as copy number variation (CNV). In humans, CNV may be inconsequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88f18188ce73e54d05eb860a33ba2ae1
https://doi.org/10.1093/genetics/iyad010
https://doi.org/10.1093/genetics/iyad010