Zobrazeno 1 - 10
of 19
pro vyhledávání: '"M K Racke"'
Autor:
S I, Aqel, E E, Kraus, N, Jena, V, Kumari, M C, Granitto, L, Mao, M F, Farinas, E Y, Zhao, G, Perottino, W, Pei, A E, Lovett-Racke, M K, Racke, J R, Fuchs, C, Li, Y, Yang
Publikováno v:
Clin Exp Immunol
Multiple sclerosis (MS) is the leading cause of non‐traumatic neurological disability in the United States in young adults, but current treatments are only partially effective, making it necessary to develop new, innovative therapeutic strategies.
Autor:
Kathleen Hawker, Elliot M. Frohman, J. Fleckenstein, M. K. Racke, Phillip D. Kramer, Teresa C. Frohman
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 70:688-692
The objective was to describe in multiple sclerosis, a cerebellar eye movement syndrome that resulted from an acute episode of inflammatory demyelination. Contrapulsion is an ocular motor disturbance characterised by a triad of (1) hypermetric saccad
Publikováno v:
The Journal of Immunology. 157:1333-1336
The B7 family of cell surface molecules expressed on APC provides accessory signals to T cells via either CD28 or CTLA-4. However, while CD28 transduces a costimulatory signal that is required for an optimal immune response, CTLA-4 transmits a negati
Role of B7:CD28/CTLA-4 in the induction of chronic relapsing experimental allergic encephalomyelitis
Publikováno v:
The Journal of Immunology. 154:1481-1490
T cell activation requires both Ag/MHC recognition and costimulatory signals. The present studies were designed to test whether the loss of tolerance to myelin basic protein (MBP) requires costimulation by members of the B7 receptor family. CTLA-4Ig,
Publikováno v:
The Journal of Immunology. 154:450-458
Experimental allergic encephalomyelitis (EAE) is an autoimmune disease characterized by central nervous system inflammation and demyelination. Retinoids regulate cell differentiation and growth by binding to and activating retinoic acid receptors, wh
Publikováno v:
The Journal of Immunology. 152:2051-2059
Experimental allergic encephalomyelitis (EAE) is an autoimmune disease that can be induced by the adoptive transfer of CD4, myelin basic protein (MBP)-specific T cells. Superantigens activate T cells expressing appropriate TCR V genes. In this study,
Publikováno v:
The Journal of Immunology. 146:3012-3017
Experimental allergic encephalomyelitis (EAE) is an autoimmune disease characterized by inflammation and demyelination in the central nervous system. The effect of the immunosuppressive molecule transforming growth factor-beta, (TGF-beta 1) on chroni
Publikováno v:
Journal of clinical immunology. 21(2)
The expression of neural regulatory molecules by immune cells that infiltrate the nervous system upon injury may be a mechanism for cross regulation between the nervous system and the immune system. Several lines of evidence implicate nerve growth fa
Publikováno v:
European journal of immunology. 31(2)
The expression of neural regulatory molecules by immune cells that infiltrate the nervous system upon injury may be a mechanism for cross-regulation between the nervous system and the immune system. Several lines of evidence implicate nerve growth fa
Publikováno v:
European journal of immunology. 29(10)
T cell co-stimulation through the CD28 receptor on T cells is critical to the induction of experimental autoimmune encephalomyelitis (EAE). In this study, expression of the co-stimulatory ligands B7-1 (CD80) and B7-2 (CD86), as well as the receptors