Anti-CD3 epsilon F(ab')2 fragments inhibit T cell expansion in vivo during graft-versus-host disease or the primary immune response to nominal antigen

Autor: B R Blazar, M K Jenkins, P A Taylor, J White, A Panoskaltsis-Mortari, R Korngold, D A Vallera

Publikováno v: The Journal of Immunology. 159:5821-5833

This study was undertaken to distinguish between several mechanisms responsible for graft-vs-host disease (GVHD) protection in anti-CD3epsilonF(ab')2 fragment (Fr)-treated recipients: TCR down-modulation, deletion, failure of expansion, or anergy ind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff3fd7e13d1db0e1b00c0f718039aebe
https://doi.org/10.4049/jimmunol.159.12.5821

Monocytes provide a novel costimulatory signal to T cells that is not mediated by the CD28/B7 interaction

Autor: J G Johnson, M K Jenkins

Publikováno v: The Journal of Immunology. 152:429-437

Resting CD4+T cells must receive nonspecific costimulatory signals from APC to produce maximal amounts of IL-2 in response to TCR signaling. The T cell-specific surface molecule CD28 is one protein that transduces a costimulatory signal following int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f052bc30b0a17cf3cb73b63a712c2edc
https://doi.org/10.4049/jimmunol.152.2.429

Immunity to mycobacterial infection (WS-061)

Autor: Y. Sekine, C. Aagaard, C. Jurasik, J. Dietrich, C. Feng, N. Yamamoto, M. Tameris, J. J. Moon, A. V. S. Hill, S. L. Fernando, J. S. Woodworth, D. L. Woodland, H. Yamamoto, Y. Yue, B. M. Saunders, J. S. Wiley, A. Hawkridge, D. Jankovic, D. Tanno, M. Hatherill, Y. Iwakura, K. Kawakami, N. Brittain, A. Rothfuchs, B. J. Gu, S. Shafiani, S. Saijo, E. Smit, S. Xiong, M. Okada, S. Nishimatsu, P. Saunderson, W. J. Britton, T. J. Scriba, Y. Adachi, A. Veldsman, C. Watson, W. A. Hanekom, S. Hashimoto, Y. Abe, K. B. Urdahl, H. McShane, Y. Nishida, A. Pong, Y. Takahashi, K. Ishii, N. Kanamaru, G. M. Winslow, D. McMurray, Y. Kaneda, S. T. Whittmer, A. Sher, N. Ohno, E. V. Tan, Y. Kita, P. Andersen, H. Mahomed, M. Tanaka, N. Mansoor, T. Miyasaka, L. van der Merwe, H. Hara, G. Tucker-Heard, C. Kishigami, M. K. Jenkins, H. Nakatani, G. D. Hussey, T. Nakajima, R. Sluyter, S. Moyo, W. Xu, W. W. Reiley, K. Takao

Publikováno v: International Immunology. 22:iii110-iii111

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::341260e98a951c2b4237067b9a8b8b2a
https://doi.org/10.1093/intimm/dxq409

Revealing the in vivo behavior of CD4+ T cells specific for an antigen expressed in Escherichia coli

Autor: Z M, Chen, M K, Jenkins

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 160(7)

The clonal expansion and anatomic location of microbe-specific CD4+ Th cells was studied by tracking the fate of adoptively transferred DO11.10 TCR transgenic T cells specific for OVA peptide 323-339/I-Ad in BALB/c mice infected s.c. with Escherichia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e4027f27fea85f33d6f5b928f0ddf34f
https://pubmed.ncbi.nlm.nih.gov/9531307

Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4

Autor: E R, Kearney, T L, Walunas, R W, Karr, P A, Morton, D Y, Loh, J A, Bluestone, M K, Jenkins

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 155(3)

The importance of CD28 costimulation to a primary T cell response in vivo was assessed in an adoptive transfer system where a small population of peptide-specific CD4+ TCR transgenic T cells can be physically tracked. Ag-dependent clonal expansion of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b68b2b0a07167873bb0ac1b8b49ddc77
https://pubmed.ncbi.nlm.nih.gov/7543510