Zobrazeno 1 - 10 of 18 pro vyhledávání: '"M K Holloway"'
1
An Implementation of a Computerized Cognitive Behavioral Treatment Program to Address Student Mental Health Needs: A Pilot Study in an After-School Program
Autor: Sara Sanders, Samantha M. K. Holloway, Mickey Losinski, Abdullah Asiri, Jessica Nelson, Jessica J. Lane, Elizabeth Rogers
Publikováno v: Professional School Counseling. 22:2156759X1983846
This study evaluated the feasibility and effectiveness of an abbreviated computerized cognitive behavioral therapy (CCBT) software program, Camp Cope-A-Lot, in an after-school setting for elementary students identified as at risk for anxiety and othe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c9d0cf023928d689021f336a828191e7
https://doi.org/10.1177/2156759x19838462
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2
A priori prediction of activity for HIV-1 protease inhibitors employing energy minimization in the active site
Autor: M K, Holloway, J M, Wai, T A, Halgren, P M, Fitzgerald, J P, Vacca, B D, Dorsey, R B, Levin, W J, Thompson, L J, Chen, S J, deSolms
Publikováno v: Journal of Medicinal Chemistry. 38:305-317
We have observed a high correlation between the intermolecular interaction energy (E inter ) calculated for HIV-1 protease inhibitor complexes and the observed in vitro enzyme inhibition. A training set of 33 inhibitors containing modifications in th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7828284b4e63a048f50ded515d7ac8fd
https://doi.org/10.1021/jm00002a012
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3
Conformationally constrained HIV-1 protease inhibitors
Autor: P.M.D. Fitzgerald, Joel R. Huff, Ken E. Starbuck, L.J. Chen, Hungate Randall W, Paul L. Darke, P. S. Anderson, M. K. Holloway, J. P. Vacca
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 4:499-504
The synsthesis and structure activity relationships of conformationally constrained analogs of the HIV-1 protease inhibitor L-685,434 are described. In addition, the X-ray crystal structure of a complex between L-700,497 and the HIV-1 protease is sho
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de8a47cac47dcdde2e49870c8cae019d
https://doi.org/10.1016/0960-894x(94)80025-1
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9
Characterization of an active single polypeptide form of the human immunodeficiency virus type 1 protease
Autor: C L DiIanni, W K Herber, Richard A. F. Dixon, Lenora Davis, Paul L. Darke, Nancy E. Kohl, M K Holloway
Publikováno v: Journal of Biological Chemistry. 265:17348-17354
The pepsin-like aspartyl proteases consist of a single polypeptide chain with topologically similar amino- and carboxyl-terminal domains, each of which contributes 1 aspartic acid residue to the active site. This structure has been proposed to have e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c0e24599f990f10118227ca1a912b3fe
https://doi.org/10.1016/s0021-9258(17)44909-x
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10
The development of cyclic sulfolanes as novel and high-affinity P2 ligands for HIV-1 protease inhibitors
Autor: A K, Ghosh, H Y, Lee, W J, Thompson, C, Culberson, M K, Holloway, S P, McKee, P M, Munson, T T, Duong, A M, Smith, P L, Darke
Publikováno v: Journal of medicinal chemistry. 37(8)
Design and synthesis of a novel series of protease inhibitors incorporating conformationally constrained cyclic ligands for the &-substrate binding site of HIV-1 protease is described. We recently reported urethanes of 3-tetrahydrofuranyl as PZ ligan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5406d566d62185a5caa66350db731afc
https://pubmed.ncbi.nlm.nih.gov/8164260
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