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Two immunodominant domains of gp41 bind antibodies which enhance human immunodeficiency virus type 1 infection in vitro

Autor: M. K. Gorny, S. Zolla-Pazner, William M. Mitchell, W E Robinson, Jian-Yin Xu

Publikováno v: Journal of Virology. 65:4169-4176

Four of eight human monoclonal antibodies (huMAbs) to gp41 were identified which could enhance human immunodeficiency virus type 1 (HIV-1) infection in vitro by complement-mediated antibody-dependent enhancement (C'-ADE). These enhancing huMAbs were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d744fe6b9e67551961f4ad6ac6e6c1db
https://doi.org/10.1128/jvi.65.8.4169-4176.1991

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Human monoclonal antibodies to the human immunodeficiency virus type 1 (HIV-1) transmembrane glycoprotein gp41 enhance HIV-1 infection in vitro

Autor: William M. Mitchell, T Sugano, E M Hersh, D Lake, M. K. Gorny, W E Robinson, Y Masuho, Jian-Yin Xu, Y. Matsumoto, Tetsuya Kawamura

Publikováno v: Proceedings of the National Academy of Sciences. 87:3185-3189

Three of 16 human monoclonal antibodies (hu-mAbs) enhanced human immunodeficiency virus type 1 (HIV-1) infection of MT-2 target cells by means of a mechanism that is dependent on complement. Enhanced infections are characterized by an increase in cyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ec08f575de6678ff34ee77a278ad7fe
https://doi.org/10.1073/pnas.87.8.3185

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Human monoclonal antibodies to the V3 loop of HIV-1 with intra- and interclade cross-reactivity

Autor: M K, Gorny, T C, VanCott, C, Hioe, Z R, Israel, N L, Michael, A J, Conley, C, Williams, J A, Kessler, P, Chigurupati, S, Burda, S, Zolla-Pazner

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 159(10)

Five human anti-V3 mAbs were generated from Ab-producing cells derived from the blood of HIV-1-infected individuals from North America and selected using the V3 peptide of a divergent clade B isolate, HIV(RF). The anti-V3(RF) mAbs were mapped to a cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::968d9b7726c131a0106e08984a5b1ced
https://pubmed.ncbi.nlm.nih.gov/9366441

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Prevalence of a V2 epitope in clade B primary isolates and its recognition by sera from HIV-1-infected individuals

Autor: Z R, Israel, M K, Gorny, C, Palmer, J A, McKeating, S, Zolla-Pazner

Publikováno v: AIDS (London, England). 11(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::df343e1cff8b699dedec2763e666b018
https://pubmed.ncbi.nlm.nih.gov/9110092

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Functional studies of bispecific antibodies directed against HIV-1 and the Fc gamma I receptor type I

Autor: M K, Gorny, T, Keler, S, Burda, C, Williams, J L, Gabriel, W M, Mitchell, Y M, Deo, S, Zolla-Pazner

Publikováno v: Antibiotics and chemotherapy. 48

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1abe2884c1c825a5ecdcd99ca67cf668
https://pubmed.ncbi.nlm.nih.gov/8726522

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Synergistic neutralization of human immunodeficiency virus type 1 by combinations of human monoclonal antibodies

Autor: S. Karwowska, S. Burda, Susan Zolla-Pazner, A. Buchbinder, M. K. Gorny, Suman Laal

Publikováno v: Journal of virology. 68(6)

The ability of antibodies to the V3 region and the CD4-binding domain (CD4bd) of human immunodeficiency virus type 1 (HIV-1) to act in synergy to neutralize HIV has been demonstrated previously. However, synergy between antibodies to other HIV-1 epit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdb85afb444baf57be6591cfb43fd495
https://pubmed.ncbi.nlm.nih.gov/7514683

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Studies with monoclonal antibodies to the V3 region of HIV-1 gp120 reveal limitations to the utility of solid-phase peptide binding assays

Autor: J P, Moore, Y, Cao, A J, Conley, R, Wyatt, J, Robinson, M K, Gorny, S, Zolla-Pazner, D D, Ho, R A, Koup

Publikováno v: Journal of acquired immune deficiency syndromes. 7(4)

Using human monoclonal antibodies (HuMAbs) r(1)-447 (L-736,523) and 19b to the V3 region of HIV-1 gp120, we have explored epitope presentation on V3-peptides and on the corresponding gp120 proteins. HuMAb r(1)-447 binds strongly to the MN and SF-2 pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::222bca7150b156a7ccce468b6e1a86ad
https://pubmed.ncbi.nlm.nih.gov/7510807

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Repertoire of neutralizing human monoclonal antibodies specific for the V3 domain of HIV-1 gp120

Autor: M K, Gorny, J Y, Xu, S, Karwowska, A, Buchbinder, S, Zolla-Pazner

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 150(2)

HIV infection induces antibodies that mediate neutralization of cell-free virus and may protect against viral infection. Neutralizing human mAb that bind to the third hypervariable domain (V3) of gp120 have been generated from PBL of HIV-seropositive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c129f80de14bc447f249b48cd126ba3e
https://pubmed.ncbi.nlm.nih.gov/7678279

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